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This PR adds a wrapper for the BioOntology which uses a local SQLite database, with sufficient content to perform refinement finding. In my benchmarks, this results in minimal discernible difference in runtimes for large refinement finding jobs while saving all the memory (about 8GB) that is normally used by an in-memory instance of the BioOntology and its transitive closure. This can allow better parallelization where memory is a bottleneck.