lrp_4.0.16
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released this
08 May 18:57
·
0 commits
to fe32d919a394e37fb22968c71fe0a4e717c91ec9
since this release
Updated short read variant calling and joint calling pipelines to run at scale (#450)
Single-sample variant calling:
- Fixied critical typo in HaplotypeCaller disk spec.
- Fixed wdl-computed divide by zero error in
SRFlowcell
outputs. - Updated
MergeVCFs
to have an option to name an output as a GVCF. - Removed deprecated GC logging flags from GATK commands.
- Fixed issue in
FastQC
if no read qualities are in the file. - Added missing annotation groups to ReblockGVCFs.
- HaplotypeCaller WDL now returns the reblocked GVCF.
Joint Calling:
- Added option to use gnarly genotyper
- Added het inputs to joint genotyping
- Fixed java memory allocation in joint genotyping to be based on memory of the VM, not hard-coded
- Fixed name of outdir in
ConvertToZarrStore
to be correct for this workflow. - Updated the zarr conversion to use parallel Dask processes and to log to stdout.
- Upped default zarr conversion memory to 32gb.
VETS:
- Added stack trace logging for errors in
ExtractVariantAnnotations
,
TrainVariantAnnotationsModel
, andScoreVariantAnnotations
. - Removed
HAPCOMP
,HAPDOM
, andHEC
from default annotations for SNP and INDEL VETS filtration on joint-called VCF files. Need to do more testing / debugging to include these in joint calling.
Misc:
- Fixed the name of the workflow in ExpandedDrugResistanceMarkerAggregation to reflect the actual name.
- Miscellaneous updates for debugging