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JenkeScheen committed Jan 31, 2025
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<a href=/outputs/targeting-opportunities/#ASAP-SARS-COV-2-NSP3-MAC1><img title="Targeting opportunity for SARS-CoV-2 nsp3 Mac1 macrodomain" width=28 src=img/status/coronaviridae_completed.png></a>
<a href=/outputs/molecules/#ASAP-SARS-COV-2-NSP3-MAC1><img title=Molecules width=28 src=img/status/coronaviridae_completed.png></a>
<a href=/outputs/structures/#ASAP-SARS-COV-2-NSP3-MAC1><img title=Structures width=28 src=img/status/coronaviridae_completed.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/coronaviridae_in-progress.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/coronaviridae_completed.png></a>
<a href=/outputs/circulating-variants/#ASAP-SARS-COV-2-NSP3-MAC1><img title="Analysis of circulating variants for SARS-CoV-2 nsp3 Mac1 macrodomain" width=28 src=img/status/coronaviridae_completed.png></a>
<a href=/outputs/target-product-profiles/#ASAP-TPP-SARS-CoV-2><img title="Target Product Profile (TPP) for SARS-CoV-2 nsp3 Mac1 macrodomain" width=28 src=img/status/coronaviridae_completed.png></a>
<a href=/outputs/target-enabling-packages/#ASAP-SARS-COV-2-NSP3-MAC1><img title="Target Enabling Package (TEP) for SARS-CoV-2 nsp3 Mac1 macrodomain" width=28 src=img/status/coronaviridae_completed.png></a>
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<a href=/outputs/targeting-opportunities/#ASAP-DENV-ZIKV-NS2B-NS3><img title="Targeting opportunity for DENV/ZIKV NS2B/3 protease" width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/molecules/#ASAP-DENV-ZIKV-NS2B-NS3><img title=Molecules width=28 src=img/status/flaviviridae_in-progress.png></a>
<a href=/outputs/structures/#ASAP-DENV-ZIKV-NS2B-NS3><img title=Structures width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/circulating-variants/#ASAP-DENV-ZIKV-NS2B-NS3><img title="Analysis of circulating variants for DENV/ZIKV NS2B/3 protease" width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/target-product-profiles/#ASAP-TPP-DENV><img title="Target Product Profile (TPP) for DENV/ZIKV NS2B/3 protease" width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/target-enabling-packages/#ASAP-DENV-ZIKV-NS2B-NS3><img title="Target Enabling Package (TEP) for DENV/ZIKV NS2B/3 protease" width=28 src=img/status/flaviviridae_completed.png></a>
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<a href=/outputs/preclinical/#ASAP-ZIKA-NS5-RDRP><img title="Preclinical (IND-enabling) studies for DENV/ZIKV/WNV RdRp polymerase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/investigational-new-drugs/#ASAP-ZIKA-NS5-RDRP><img title="Investigational New Drug (IND) approval for DENV/ZIKV/WNV RdRp polymerase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/clinical-trials/#ASAP-ZIKA-NS5-RDRP><img title="Clinical trial for DENV/ZIKV/WNV RdRp polymerase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/new-drug-approvals/#ASAP-ZIKA-NS5-RDRP><img title="New Drug Approval (NDA) for DENV/ZIKV/WNV RdRp polymerase" width=28 src=img/status/flaviviridae_not-started.png></a></div></div></div><div class=container><div class=row><div class=col-4 style=display:flex;align-items:center><b>DENV/ZIKV/WNV NS5 methyltransferase</b></div><div class=col-8><img title="No approved drugs" width=28 src=img/status/clinically-unprecedented_completed.png>
<a href=/outputs/new-drug-approvals/#ASAP-ZIKA-NS5-RDRP><img title="New Drug Approval (NDA) for DENV/ZIKV/WNV RdRp polymerase" width=28 src=img/status/flaviviridae_not-started.png></a></div></div></div><div class=container><div class=row><div class=col-4 style=display:flex;align-items:center><b>DENV/ZIKV/WNV NS3 helicase</b></div><div class=col-8><img title="No approved drugs" width=28 src=img/status/clinically-unprecedented_completed.png>
<img title="Novel mechanism of action" width=28 src=img/status/novel-mechanism_completed.png>
<img title="Broad spectrum" width=28 src=img/status/broad-spectrum_completed.png>
<a href=https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865><img title="Funding source for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/icons/niaid-logo.png></a>
<a href><img title="Target for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/targets/DENV-ns2b-ns3.png></a>
<a href=/outputs/targeting-opportunities/#ASAP-ZIKA-NS3-HELICASE><img title="Targeting opportunity for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title=Molecules width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/structures/#ASAP-ZIKA-NS3-HELICASE><img title=Structures width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/circulating-variants/#ASAP-ZIKA-NS3-HELICASE><img title="Analysis of circulating variants for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/target-product-profiles/#ASAP-TPP-ZIKA><img title="Target Product Profile (TPP) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/target-enabling-packages/#ASAP-ZIKA-NS3-HELICASE><img title="Target Enabling Package (TEP) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_play.png></a>
<a href=/outputs/target-candidate-profiles/#ASAP-ZIKA-NS3-HELICASE><img title="Target Candidate Profile (TCP) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/assay-cascades/#ASAP-ZIKA-NS3-HELICASE><img title="Assay cascade for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title="Hit-to-lead for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title="Covalent targeting for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title="Lead optimization for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/preclinical/#ASAP-ZIKA-NS3-HELICASE><img title="Preclinical (IND-enabling) studies for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/investigational-new-drugs/#ASAP-ZIKA-NS3-HELICASE><img title="Investigational New Drug (IND) approval for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/clinical-trials/#ASAP-ZIKA-NS3-HELICASE><img title="Clinical trial for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/new-drug-approvals/#ASAP-ZIKA-NS3-HELICASE><img title="New Drug Approval (NDA) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a></div></div></div><div class=container><div class=row><div class=col-4 style=display:flex;align-items:center><b>DENV/ZIKV/WNV NS5 methyltransferase</b></div><div class=col-8><img title="No approved drugs" width=28 src=img/status/clinically-unprecedented_completed.png>
<img title="Novel mechanism of action" width=28 src=img/status/novel-mechanism_completed.png>
<img title="Broad spectrum" width=28 src=img/status/broad-spectrum_completed.png>
<a href=https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865><img title="Funding source for DENV/ZIKV/WNV NS5 methyltransferase" width=28 src=img/icons/niaid-logo.png></a>
Expand All @@ -203,27 +223,7 @@
<a href=/outputs/preclinical/#ASAP-DENV-NS5-MT><img title="Preclinical (IND-enabling) studies for DENV/ZIKV/WNV NS5 methyltransferase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/investigational-new-drugs/#ASAP-DENV-NS5-MT><img title="Investigational New Drug (IND) approval for DENV/ZIKV/WNV NS5 methyltransferase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/clinical-trials/#ASAP-DENV-NS5-MT><img title="Clinical trial for DENV/ZIKV/WNV NS5 methyltransferase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/new-drug-approvals/#ASAP-DENV-NS5-MT><img title="New Drug Approval (NDA) for DENV/ZIKV/WNV NS5 methyltransferase" width=28 src=img/status/flaviviridae_not-started.png></a></div></div></div><div class=container><div class=row><div class=col-4 style=display:flex;align-items:center><b>DENV/ZIKV/WNV NS3 helicase</b></div><div class=col-8><img title="No approved drugs" width=28 src=img/status/clinically-unprecedented_completed.png>
<img title="Novel mechanism of action" width=28 src=img/status/novel-mechanism_completed.png>
<img title="Broad spectrum" width=28 src=img/status/broad-spectrum_completed.png>
<a href=https://reporter.nih.gov/search/EpbjKrq7Kki8EBHx4eMWbw/project-details/10513865><img title="Funding source for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/icons/niaid-logo.png></a>
<a href><img title="Target for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/targets/DENV-ns2b-ns3.png></a>
<a href=/outputs/targeting-opportunities/#ASAP-ZIKA-NS3-HELICASE><img title="Targeting opportunity for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title=Molecules width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/structures/#ASAP-ZIKA-NS3-HELICASE><img title=Structures width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/circulating-variants/#ASAP-ZIKA-NS3-HELICASE><img title="Analysis of circulating variants for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/target-product-profiles/#ASAP-TPP-ZIKA><img title="Target Product Profile (TPP) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_completed.png></a>
<a href=/outputs/target-enabling-packages/#ASAP-ZIKA-NS3-HELICASE><img title="Target Enabling Package (TEP) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_play.png></a>
<a href=/outputs/target-candidate-profiles/#ASAP-ZIKA-NS3-HELICASE><img title="Target Candidate Profile (TCP) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/assay-cascades/#ASAP-ZIKA-NS3-HELICASE><img title="Assay cascade for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title="Hit-to-lead for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title="Covalent targeting for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-ZIKA-NS3-HELICASE><img title="Lead optimization for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/preclinical/#ASAP-ZIKA-NS3-HELICASE><img title="Preclinical (IND-enabling) studies for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/investigational-new-drugs/#ASAP-ZIKA-NS3-HELICASE><img title="Investigational New Drug (IND) approval for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/clinical-trials/#ASAP-ZIKA-NS3-HELICASE><img title="Clinical trial for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a>
<a href=/outputs/new-drug-approvals/#ASAP-ZIKA-NS3-HELICASE><img title="New Drug Approval (NDA) for DENV/ZIKV/WNV NS3 helicase" width=28 src=img/status/flaviviridae_not-started.png></a></div></div></div></div>&nbsp
<a href=/outputs/new-drug-approvals/#ASAP-DENV-NS5-MT><img title="New Drug Approval (NDA) for DENV/ZIKV/WNV NS5 methyltransferase" width=28 src=img/status/flaviviridae_not-started.png></a></div></div></div></div>&nbsp
</div><div class=row><div class=col-1 style=display:flex;align-items:center><a href=../outputs/viral-families/#picornaviridae><img width=80 src=img/viruses/picornaviridae.png></a></div><div class=col-11><div class=container><div class=row><div class=col-4 style=display:flex;align-items:center><b>EV-D68/A71 3C protease</b></div><div class=col-8><img title="No approved drugs" width=28 src=img/status/clinically-unprecedented_completed.png>
<img title="Novel mechanism of action" width=28 src=img/status/novel-mechanism_completed.png>
<img title="Broad spectrum" width=28 src=img/status/broad-spectrum_completed.png>
Expand All @@ -232,13 +232,13 @@
<a href=/outputs/targeting-opportunities/#ASAP-EVD68-3CLPRO><img title="Targeting opportunity for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-3CLPRO><img title=Molecules width=28 src=img/status/picornaviridae_in-progress.png></a>
<a href=/outputs/structures/#ASAP-EVD68-3CLPRO><img title=Structures width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/picornaviridae_in-progress.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/circulating-variants/#ASAP-EVD68-3CLPRO><img title="Analysis of circulating variants for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/target-product-profiles/#ASAP-TPP-EVD68-PEDIATRIC><img title="Target Product Profile (TPP) for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/target-enabling-packages/#ASAP-EVD68-3CLPRO><img title="Target Enabling Package (TEP) for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/target-candidate-profiles/#ASAP-EVD68-3CLPRO><img title="Target Candidate Profile (TCP) for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/assay-cascades/#ASAP-EVD68-3CLPRO><img title="Assay cascade for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-3CLPRO><img title="Hit-to-lead for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_play.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-3CLPRO><img title="Hit-to-lead for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_paused.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-3CLPRO><img title="Covalent targeting for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-3CLPRO><img title="Lead optimization for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/preclinical/#ASAP-EVD68-3CLPRO><img title="Preclinical (IND-enabling) studies for EV-D68/A71 3C protease" width=28 src=img/status/picornaviridae_not-started.png></a>
Expand All @@ -258,7 +258,7 @@
<a href=/outputs/target-enabling-packages/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Target Enabling Package (TEP) for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/target-candidate-profiles/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Target Candidate Profile (TCP) for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/assay-cascades/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Assay cascade for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_in-progress.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Hit-to-lead for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_play.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Hit-to-lead for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_paused.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Covalent targeting for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Lead optimization for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/preclinical/#ASAP-EVD68-EVA71-VP1-CAPSID><img title="Preclinical (IND-enabling) studies for EV-D68/A71 capsid assembly" width=28 src=img/status/picornaviridae_not-started.png></a>
Expand All @@ -272,13 +272,13 @@
<a href=/outputs/targeting-opportunities/#ASAP-EVD68-2APRO><img title="Targeting opportunity for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-2APRO><img title=Molecules width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/structures/#ASAP-EVD68-2APRO><img title=Structures width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/publications/><img title=Publications width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/circulating-variants/#ASAP-EVD68-2APRO><img title="Analysis of circulating variants for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/target-product-profiles/#ASAP-TPP-EVD68-PEDIATRIC><img title="Target Product Profile (TPP) for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/target-enabling-packages/#ASAP-EVD68-2APRO><img title="Target Enabling Package (TEP) for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_completed.png></a>
<a href=/outputs/target-candidate-profiles/#ASAP-EVD68-2APRO><img title="Target Candidate Profile (TCP) for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/assay-cascades/#ASAP-EVD68-2APRO><img title="Assay cascade for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-2APRO><img title="Hit-to-lead for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-2APRO><img title="Hit-to-lead for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_play.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-2APRO><img title="Covalent targeting for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/molecules/#ASAP-EVD68-2APRO><img title="Lead optimization for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_not-started.png></a>
<a href=/outputs/preclinical/#ASAP-EVD68-2APRO><img title="Preclinical (IND-enabling) studies for EV-D68/A71 2A protease" width=28 src=img/status/picornaviridae_not-started.png></a>
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