We performed a genetic analysis of left ventricle (LV) MRI traits and heart failure (HF), imputing gene and protein expression from GWAS summary stistics, followed by pathway and netowrk clustering. The project was accepted and will be presented at the Pacific Symposium on Biocomputing in January 2025.
Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass. Khurshid S, et al. Nat Commun. 2023 Mar 21;14(1):1558. doi: 10.1038/s41467-023-37173-w. PMID: 36944631
Genetic Analysis of Right Heart Structure and Function in 40,000 People. Pirruccello JP, et al. Nat Genet. 2022 Jun;54(6):792-803. doi: 10.1038/s41588-022-01090-3. PMID: 35697867
Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum. Lee DSM, et al. medRxiv. 2023 Oct. doi: 10.1101/2023.07.16.23292724
- TWAS using S-PrediXcan
- PWAS using in S-PrediXcan