multi-group cTWAS v0.5.34

• Created post-processing functions to automate post-processing steps for region merging and LD mismatch analysis.
• Created function to get boundary genes using mapping_table and function to select boundary genes.
• The ctwas_sumstats() function and assemble_region_data() function no longer return boundary genes.

multi-group cTWAS v0.5.22

• Included posterior effect size (mu) in the fine-mapping results.
• Fixed minor bugs.

multi-group cTWAS v0.5.20

Updates to multi-group cTWAS:

• Updated EM with cTWAS SER model for faster speed.
• Updated EM and finemapping with "ctwas" null model.
• Allowed EM to stop when converged, instead of running all iterations.
• Corrected group_size returned from EM.
• Estimated s.e. and p-value for enrichment parameter
• Updated region screening with SER model and not estimating L.
• Allowed returning "susie" result object and priors in fine-mapping output.
• Set default group_prior_var_structure = "shared_all".
• Set default thin = 1.
• Set default filter_cs = FALSE in combine_gene_pips().
• Set default LD-mismatch p_diff_thresh = 5e-6.

multi-group cTWAS v0.4.21

This version implements multi-group cTWAS method, which jointly models multiple types of molecular traits across different contexts, with updated post-processing functions.

cTWAS v0.1.38

This version implements the original cTWAS method (single group version) as in NG (2024) paper. https://doi.org/10.1038/s41588-023-01648-9