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use vignette as README and add citation, closes #74
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# SingleCellMultiModal | ||
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This is a project for downloading Single Cell Multi-Modal data and representing | ||
them as MultiAssayExperiment objects. It will eventually be submitted to | ||
Bioconductor as an ExperimentHub package. | ||
## Overview | ||
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`SingleCellMultiModal` is an R package that provides a convenient and | ||
user-friendly representation of multi-modal data using | ||
`MultiAssayExperiment`. This package introduces a suite of single-cell | ||
multimodal landmark datasets for benchmarking and testing multimodal | ||
analysis methods via the `ExperimentHub` Bioconductor package. The scope | ||
of this package is to provide efficient access to a selection of | ||
curated, pre-integrated, publicly available landmark datasets for | ||
methods development and benchmarking. | ||
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## Installation | ||
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``` r | ||
if (!requireNamespace("BiocManager", quietly = TRUE)) | ||
install.packages("BiocManager") | ||
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BiocManager::install("SingleCellMultiModal") | ||
``` | ||
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## Loading packages | ||
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``` r | ||
library(SingleCellMultiModal) | ||
library(MultiAssayExperiment) | ||
``` | ||
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# Citing SingleCellMultiModal | ||
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Your citations are crucial in keeping our software free and open source. | ||
To cite our package see the citation (@Eckenrode2023-yq) in the | ||
Reference section. You may also browse to the publication at the link | ||
[here](https://doi.org/10.1371/journal.pcbi.1011324). | ||
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## Representation | ||
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Users can obtain integrative representations of multiple modalities as a | ||
`MultiAssayExperiment`, a common core Bioconductor data structure relied | ||
on by dozens of multimodal data analysis packages. | ||
`MultiAssayExperiment` harmonizes data management of multiple | ||
experimental assays performed on an overlapping set of specimens. | ||
Although originally developed for patient data from multi-omics cancer | ||
studies, the `MultiAssayExperiment` framework naturally applies also to | ||
single cells. A schematic of the data structure can be seen below. In | ||
this context, “patients” are replaced by “cells”. We use | ||
`MultiAssayExperiment` because it provides a familiar user experience by | ||
extending `SummarizedExperiment` concepts and providing open ended | ||
compatibility with standard data classes present in Bioconductor such as | ||
the `SingleCellExperiment`. | ||
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<img src="https://github.com/waldronlab/MultiAssayExperiment/blob/c3c59a094e5a08111ee98b9f69579db5634d9fd4/vignettes/MultiAssayExperiment.png?raw=true" width="100%" /> | ||
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# Contributions | ||
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Want to contribute to the `SingleCellMultiModal` package? We welcome | ||
contributions from the community. Please refer to our [Contributing | ||
Guidelines](https://github.com/waldronlab/SingleCellMultiModal/wiki/Contributing-Guidelines) | ||
for more details. | ||
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## Contributing | ||
## Further resources | ||
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Want to contribute a dataset? See the [Contributing Guidelines][] | ||
For more information on the `MultiAssayExperiment` data structure, | ||
please refer to @Ramos2017-tk as well as the [MultiAssayExperiment | ||
vignette](https://bioconductor.org/packages/release/bioc/vignettes/MultiAssayExperiment/inst/doc/MultiAssayExperiment.html). | ||
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[Contributing Guidelines]: https://github.com/waldronlab/SingleCellMultiModal/wiki/Contributing-Guidelines | ||
# References |
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--- | ||
output: github_document | ||
knit: (function(inputFile, encoding) { | ||
rmarkdown::render(inputFile, encoding = encoding, output_dir = "../../") }) | ||
--- | ||
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```{r, include = FALSE} | ||
knitr::opts_chunk$set( | ||
collapse = TRUE, | ||
comment = "#>", | ||
cache = TRUE, | ||
out.width = "100%" | ||
) | ||
``` | ||
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```{r,echo=FALSE,eval=FALSE} | ||
## Generate the ./README.md (relative to base folder) | ||
rmarkdown::render(input = "inst/scripts/README.Rmd", output_dir = ".") | ||
``` | ||
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```{r, child="../../vignettes/SingleCellMultiModal.Rmd"} | ||
``` |
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