ecc: introduces the vascular proliferation characteristic

[madetunj]

This pull request adds the Vascular Proliferation ECC

Close #7

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[claymcleod]

This still needs to be filled out: how will the ECC be assigned, what will the permissible values be, and what do each of the permissible values mean.

[madetunj]

I'm unsure if the "values" should be a feature of the ECC. Having a binary "true/false" seems focused on the ontology itself and not the ECC. It may be useful to have a separate classification or database linking ECCs to their corresponding ontologies.

[madetunj]

I'm unsure if the "values" should be a feature of the ECC. Having a binary "true/false" seems focused on the ontology itself and not the ECC. It may be useful to have a separate classification or database linking ECCs to their corresponding ontologies.

[Ssandor13]

state: proposed
name: Vascular Proliferation
identifier: ECC-MORPH-000001
rfc: #7
assignment: morphological
description: |
Judah Folkman first discovered the concept of rapid blood vessel growth in 1971, as detailed in his publication in the New England Journal of Medicine (NEJM), referenced here.
His work laid the foundation for further research into angiogenesis, the process of forming new blood vessels.

Few things:

1. I think we should extend the definition for this ECC. The description is too vague, e.g., "Vascular proliferation refers to the abnormal increase in the number of blood vessels within a tissue, often as a response to hypoxia, tumor growth, or injury. In the context of brain tumors, particularly high-grade gliomas (e.g., glioblastoma, diffuse midline glioma), vascular proliferation is a hallmark feature of aggressive tumor behavior and is associated with rapid growth, resistance to therapy, and poor prognosis."
2. There are different forms of vascular proliferation and we should consider how to model that here. Increased Microvascular Density (MVD) is a characteristic for this ECC, Endothelial Cell Hyperplasia, Glomeruloid Vascular Proliferation (GVP), etc - I think this is context of what Clay is alluding to in the binary section.