0.10.1

• We have restored and improved gene constraint tooltips, using gnomAD as our new source of data. Using this feature on an existing site will require updating LocusZoom.Datasources options (see below). Tooltips now include o/e constraint metrics and confidence intervals. Genes with no constraint information now hide the table rather than showing blank fields.
  • Currently gene constraint information is only available for build GRCh37
• Fix a bug where panel titles were sometimes rendered twice

Breaking changes

• Old layouts using GeneConstraintLZ will need to be updated to use the new gnomAD API URL, as well as to correctly specify the genome build. For example: .add("constraint", ["GeneConstraintLZ", { url: "https://gnomad.broadinstitute.org/api", params: { build: 'GRCh37' } }]);
  • Although we generally try to preserve backwards compatibility, in this case, the old GeneConstraintLZ datasource was designed for a server (exAC) that is no longer available, and no custom datasources were found in an audit of users. Therefore the datasource has been redefined to use a different request and response format based on gnomAD.