Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

DTDA is-drug-target wrong answer #37

Open
bgyori opened this issue Aug 22, 2017 · 1 comment
Open

DTDA is-drug-target wrong answer #37

bgyori opened this issue Aug 22, 2017 · 1 comment

Comments

@bgyori
Copy link
Member

bgyori commented Aug 22, 2017

The answer to

(REQUEST :CONTENT (IS-DRUG-TARGET :DRUG "<ekb timestamp=\"20170822T153926\">
  <TERM id=\"V35676\" dbid=\"MESH:C484810|PC:5494449|NCIT:C98053\">
    <type>ONT::PHARMACOLOGIC-SUBSTANCE</type>
    <name>TOZASERTIB</name>
    <drum-terms>
      <drum-term dbid=\"NCIT:C98053\" match-score=\"1.0\" name=\"tozasertib\" matched-name=\"tozasertib\">
        <types>
          <type>ONT::PHARMACOLOGIC-SUBSTANCE</type>
        </types>
      </drum-term>
      <drum-term dbid=\"PC:5494449\" name=\"Tozasertib\" matched-name=\"Tozasertib\" match-score=\"0.99587\">
        <types>
          <type>ONT::PHARMACOLOGIC-SUBSTANCE</type>
        </types>
      </drum-term>
      <drum-term match-score=\"0.65301\" name=\"VX680\" matched-name=\"Tozasertib\" dbid=\"MESH:C484810\">
        <types>
          <type>ONT::PHARMACOLOGIC-SUBSTANCE</type>
        </types>
      </drum-term>
    </drum-terms>
  </TERM>
</ekb>" :TARGET "<ekb timestamp=\"20170822T153926\">
  <TERM id=\"V35915\" dbid=\"HGNC:11772|NCIT:C51730|UP:P36897|NCIT:C30098\">
    <type>ONT::GENE-PROTEIN</type>
    <name>TGFBR-1</name>
    <drum-terms>
      <drum-term dbid=\"HGNC:11772\" matched-name=\"TGFBR1\" name=\"transforming growth factor beta receptor 1\" match-score=\"1.0\">
        <types>
          <type>ONT::GENE</type>
        </types>
        <xrefs>
          <xref dbid=\"UP:P36897\"/>
        </xrefs>
      </drum-term>
      <drum-term name=\"TGFBR1\" matched-name=\"TGFBR1\" match-score=\"1.0\" dbid=\"NCIT:C51730\">
        <types>
          <type>ONT::GENE</type>
        </types>
      </drum-term>
      <drum-term dbid=\"NCIT:C30098\" name=\"transforming growth factor beta receptor-I\" match-score=\"0.82857\" matched-name=\"TGFBR1\">
        <types>
          <type>ONT::PROTEIN</type>
        </types>
      </drum-term>
    </drum-terms>
  </TERM>
</ekb>") :REPLY-WITH DTDA-QUERY-328 :sender BA)

should be TRUE i.e.

(reply :content (SUCCESS :is-target TRUE) :receiver BA :in-reply-to DTDA-QUERY-328).

It is currently FALSE for some reason.

@bgyori
Copy link
Member Author

bgyori commented Aug 22, 2017

Okay, so this is technically not an error but perhaps the behavior defined here should be changed. Currently is-drug-target only looks at nominal targets and not all targets listed, and TGFBR1 isn't the nominal target of Tozasertib according to the database.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant