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@Alexander-Sol Alexander-Sol released this 10 Feb 21:09
· 70 commits to master since this release
1.0.1
2d12697
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Learn about vigilant mode.

Hotfix

Fixed issue where certain runtime dependencies were not installed, causing MetaMorpheus to crash while performing a search.

Major Changes

  • MetaMorpheus 1.0.0 requires .NET 6.0, which can be found here dotnet.microsoft.com/en-us/download/dotnet/6.0
  • Spectral Library Search: Users can search their data against spectral libraries in the .msp format.
  • Spectrum Library Generation: Users can create and export spectral libraries using peptides identified in their data. This includes posttranslationally modified peptides discovered through GPTMD.
  • Enhanced Match Between Runs (MBR): Enhanced MBR provides increased certainty for label-free quantification experiments by locating spectra associated with matches. This is an optional step that is performed after quantification in FlashLFQ. It is intended for use with single cell proteomics data.
  • Top-down Search: Added the ability to search top-down proteomics data by setting the protease type to “top-down.” Users can also search for truncated proteins by checking the box labeled “Add Protein Truncation and Proteolysis Products” under Advanced Options > File Loading Parameters.

Feature Updates

  • Added support for TMTpro-18
  • Added option to set file-specific dissociation type, which permits simultaneous search of raw files with different fragmentation types

MetaDraw Updates

  • Optimized visualization of Top-Down results
  • Increased support for visualization of chimeric spectra
  • Increased support for visualization of ambiguous spectra
  • Added several new plots including histograms of fragment PPM Errors, precursor masses, precursor m/z, hydrophobicity scores, and a scatter plot of precursor ppm error vs retention time
  • Allow for sorting and searching results by protein name, organism and FDR score
  • Allow for filtering displayed results to visualize by FDR and ambiguity level
  • Added png, jpeg, wmf, tiff, and bitmap as plot export options
  • Enabled full customization of spectrum description in spectral match view
  • Enabled full customization of matched ion and PTM colors
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