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clean excel output
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sigven committed Apr 24, 2021
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* Which members of the query set are associated with cellular loss-of-fitness in CRISPR/Cas9 whole-genome drop out screens of cancer cell lines (i.e. reduction of cell viability elicited by a gene inactivation)? Which targets are prioritized therapeutic targets, considering fitness effects and genomic biomarkers in combination?

### News
* April 25th 2021: **0.9.4 release**
* Cleaned Excel output
* April 24th 2021: **0.9.3 release**
* Added option to _onco_enrich_ that may ignore cytosol as a structure in subcelluar heatmap
* Added interactive table with recurrent somatic variants (TCGA) overlapping query set in the _SNVs/InDels_ section
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### Example report

[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.4650367.svg)](https://doi.org/10.5281/zenodo.4650367)

[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.4718011.svg)](https://doi.org/10.5281/zenodo.4718011)

### Getting started

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* `project_title = "cMYC_BioID_screen"`
* `project_owner = "Raught et al."`

and produced the [following HTML report with results](https://doi.org/10.5281/zenodo.4650367).
and produced the [following HTML report with results](https://doi.org/10.5281/zenodo.4718011).

Below are R commands provided to reproduce the example output. __NOTE__: Replace "LOCAL_FOLDER" with a directory on your local computer:

* `library(oncoEnrichR)`
* `myc_interact_targets <- read.csv(system.file("extdata","myc_data.csv", package = "oncoEnrichR"), stringsAsFactors = F)`
* `myc_report <- oncoEnrichR::onco_enrich(query = myc_interact_targets$symbol, project_title = "cMYC_BioID_screen", project_owner = "Raught et al.")`
* `myc_report <- oncoEnrichR::onco_enrich(query = myc_interact_targets$symbol, show_cell_tissue = T, project_title = "cMYC_BioID_screen", project_owner = "Raught et al.")`
* `oncoEnrichR::write(report = myc_report, file = "LOCAL_FOLDER/myc_report_oncoenrichr.html", format = "html")`
* `oncoEnrichR::write(report = myc_report, file = "LOCAL_FOLDER/myc_report_oncoenrichr.xlsx", format = "excel")`

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