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sigven committed Mar 14, 2021
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* Which members of the target set are associated with cellular loss-of-fitness in CRISPR/Cas9 whole-genome drop out screens of cancer cell lines (i.e. reduction of cell viability elicited by a gene inactivation)?

### News
* March 14th 2021: --**0.8.9 release**
* March 14th 2021: **0.8.9 release**
* Query verification section
* Removed lower limit of n = 20 entries in queryset
* February 27th 2021: -**0.8.8 release**
* Data updates (CancerMine)
* February 27th 2021: **0.8.8 release**
* Data updates (GENCODE, Open Targets Platform, UniProt KB, EFO, DiseaseOntology, KEGG)
* New: Inclusion of curated signalling pathways from [NetPath](http://www.netpath.org)

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Data harvested from the following resources form the backbone of _oncoEnrichR_:

* [Open Targets Platform](https://targetvalidation.org) - drug-target associations and disease-target associations
* [Open Targets Platform](https://targetvalidation.org) - human drug-target associations and comprehensive disease-target associations
* [CancerMine](http://bionlp.bcgsc.ca/cancermine/) - literature-mined database of drivers, oncogenes and tumor suppressors in cancer
* [The Cancer Genome Atlas](https://portal.gdc.cancer.gov/) - gene aberration frequencies and co-expression patterns in ~9,500 primary tumor samples
* [The Human Protein Atlas]() - expression data for healthy human tissues ([GTex](https://gtexportal.org/home/))/cell types, and prognostic gene expression associations in cancer
* [Molecular Signatures Database (MSigDB)](http://software.broadinstitute.org/gsea/msigdb/index.jsp) - collection of annotated (e.g. towards pathways) genesets for enrichment/overrepresentation analysis. This includes genesets from [Gene Ontology](http://geneontology.org/), [Reactome](https://reactome.org/), [KEGG](https://www.genome.jp/kegg/pathway.html), [NetPath signaling transduction pathways](http://www.netpath.org), [WikiPathways](https://www.wikipathways.org/index.php/WikiPathways), [BIOCARTA](https://maayanlab.cloud/Harmonizome/dataset/Biocarta+Pathways), as well as curated [immunologic](https://www.gsea-msigdb.org/gsea/msigdb/collections.jsp#C7) and [cancer-specific](https://www.gsea-msigdb.org/gsea/msigdb/collections.jsp#C6) signatures.
* [Molecular Signatures Database (MSigDB)](http://software.broadinstitute.org/gsea/msigdb/index.jsp) - collection of annotated (e.g. towards pathways) genesets for enrichment/overrepresentation analysis. This includes genesets from [Gene Ontology](http://geneontology.org/), [Reactome](https://reactome.org/), [KEGG](https://www.genome.jp/kegg/pathway.html), [WikiPathways](https://www.wikipathways.org/index.php/WikiPathways), [BIOCARTA](https://maayanlab.cloud/Harmonizome/dataset/Biocarta+Pathways), as well as curated [immunologic](https://www.gsea-msigdb.org/gsea/msigdb/collections.jsp#C7) and [cancer-specific](https://www.gsea-msigdb.org/gsea/msigdb/collections.jsp#C6) signatures.
* [NetPath](http://www.netpath.org) - signaling transduction pathways
* [STRING](https://string-db.org) - protein-protein interaction database
* [CORUM](https://mips.helmholtz-muenchen.de/corum/) - protein complex database
* [ComPPI](http://comppi.linkgroup.hu/) - subcellular compartment database
* [Project Score](https://score.depmap.sanger.ac.uk) - Database on the effects on cancer cell line viability elicited by CRISPR-Cas9 mediated gene activation



### Example report

[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.4603719.svg)](https://doi.org/10.5281/zenodo.4603719)
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