ArtiCull (Artifact Culler) is a variant call refinement algorithm for single-cell whole-genome sequencing (scWGS) data. It enables single nucleotide variant (SNV) based analyses in scWGS, including mutational signature and evolutionary analyses.
For details on running ArtiCull, please visit https://articull.readthedocs.io/en/latest/
If you encounter any problems, have questions, or would like to provide feedback, please open an issue on GitHub.
If you use ArtiCull in your research, please cite our preprint:
Satas, G., Myers, M. A., McPherson, A., & Shah, S. P. (2025). Inferring active mutational processes in cancer using single cell sequencing and evolutionary constraints. bioRxiv. doi:10.1101/2025.02.24.639589