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Issue initially reported here:
satijalab/seurat#7879
Integration preprocessing took long (~10min in my case with 120 000 cells and 61 layers). Time was nearly completely spent on
Seurat:::CreateIntegrationGroup
, more specifically on:Slow computing here was caused by the sapply function in seurat-object
seurat-object/R/logmap.R
Lines 238 to 247 in 58bf437
I rewrote this (also thanks to ChatGPT) using logical indexing.
This speeds up computation > 1000x in my use case from 10 min to less than 1 s. So "real" integration steps start nearly instantaneously.
For a reproducible example use: