Open MCRA Core 10.1.0 Update

The attached binary file MCRA.CLI.10.1.0.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 8 runtime
to be installed on your computer.

Version 10.1.0 (2024-08-15)

Added

• Create PBK modelng mechanism to allow selection of outputs from multiple compartments (#1927)
• Add install scripts for Python 3.12 to support roadrunner SBML (#1965)
• Update PARC-HBM data format reader to support codebook v2.4 (#1970)

Changed

• Restructure MCRA settings XML format to group settings per module (#581)
• Migrate code base from .NET 6 to .NET 8 (#1833)
• Refactor PBK models and their use in internal exposures and hazard characterisations module (#1933)
• Upgrade R to version 4.4.1 and rtools to 4.4 (#1966)

Fixed

• Cannot convert to target matrix blood when blood is not present as sampling method in HBM data (#1960)
• Output sections are still visible when suppressed in the action settings file (#1969)
• Data formats templates readme text contains invalid URLs (#1979)
• Co-exposure tables fails for aggregate (#1983)
• Human monitoring individuals statistics does not reflect individuals in the further analysis (#1986)

Open MCRA Core 10.0.15 Update

The attached binary file MCRA.CLI.10.0.15.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.15 (2024-06-21)

Fixed

• Percentages in risks are not correct (#1962)
• Nominal value used in pies contributions, also in uncertainty run (#1963)

Open MCRA Core 10.0.14 Update

The attached binary file MCRA.CLI.10.0.14.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.14 (2024-06-18)

Fixed

• SA Risk steatosis from imazalil seems broken (#1948)
• Show legend MCR plot when exclude privacy sensitive data is selected (#1949)
• Wrong unit for hair in hazard characterisations (#1957)
• Kinetic conversion to blood when blood is not present as sampling method in HBM data (#1959)
• Fix resampling of kinetic conversion factors in uncertainty run

Open MCRA Core 10.0.13 Update

The attached binary file MCRA.CLI.10.0.13.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.13 (2024-05-28)

Added

• Add settings tiers for Prospective Dietary CRA (EFSA 2023) (#1924)

Fixed

• Order of exposures in risks percentile table (#1945)
• HBM data gives sequence contains no elements when all body weights are missing (#1946)

Open MCRA Core 10.0.12 Update

The attached binary file MCRA.CLI.10.0.12.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.12 (2024-05-21)

Added

• Kinetic conversion for specific biomarkers in hbm analysis (#1827)
• Implementation of SBML generic model (#1910)
• Implement beta distribution for exposure biomarker conversion (#1911)
• Add lod and loq columns to table in hbm data (#1912)
• Adding opex worker-bystander-resident results (#1919)
• Risks, add contributions to risks for individuals for upper distribution (#1936)

Changed

• Combine different urine sampling types (#1880)
• Decouple MCR settings / analysis in different modules (e.g. MCR in Risks and HBM analysis) (#1931)

Fixed

• Output standard action should not report on age dependent hc subgroups when there are no subgroups (#1913)
• PARC T6.2.3 CS Pesticides: fixed uncertainty analysis demonstration (#1916)
• Exclude substances in output of hbm analysis that were not measured (#1917)
• Do not show substances from other matrices in hbm concentrations by substance before conversion (#1922)
• Set settings up-to-date in settings tiers for acute/chronic (#1929)
• MCR plot PFAS Risk action fails (#1930)

Open MCRA Core 10.0.11 Update

The attached binary file MCRA.CLI.10.0.11.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.11 (2024-04-12)

Added

• Filtering of hbm data on time points (#1782)
• Running two opex products for compute action single value non-dietary exposures (#1796)
• Specific gravity from creatinine urine adjustment method by Busgang et al. (#1874)
• Option in to skip privacy sensitive outputs in report (#1882)
• New expression type for specific gravity (#1896)
• Add legend for stacked histogram (#1901)
• Implement new option nondetects handling (#1905)

Changed

• Split Busgang urine specific gravity normalisation into age and non-age dependent methods (#1903)
• Draw from censored lognormal using nondetect and nonquantification information (#1904)

Fixed

• Remove hbm analysis option to convert using default value 1 (#1829)
• Limit hbm analysis to active substances only (#1865)

Open MCRA Core 10.0.10 Update

The attached binary file MCRA.CLI.10.0.10.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.10 (2024-03-07)

Added

• Data tables for single value non-dietary exposures (#1860)
• Add warning for missing substances in CAG (#1864)

Changed

• MCRA boxplots: adapt for substances with only a few positive measurements (#1888, #1881)

Fixed

• Correct random seed for drawing market shares in market shares calculator
• Use market shares calculated by food conversion instead of the raw market shares
• Hide module points of departure when use data is selected for hazard characterisations (#1887)
• Missing uncertainty results in several Risk exposure output sections
• Apply the complete-cases filter before kinetic conversion and biomarker conversion

Open MCRA Core 10.0.9 Update

The attached binary file MCRA.CLI.10.0.9.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.9 (2024-02-27)

Added

• New module single value non-dietary exposures (#1733)
• Implement 'use kinetic conversion factor subgroup' setting (#1868)
• Add exposure and hazard by age section with chart for age dependent HC analyses (#1873)
• Add specific gravity from creatinine adjusted method Carrieri 2001 (#1874)

Changed

• HBM analysis: update biomarker conversion to allow for biomarker conversion subgroups (age/sex) (#1844)
• Move kinetic conversion factors and exposure biomarker conversion to calculator, repair reproducability (#1870)

Fixed

• Kernel calculation in R for violin plots fails when vector contains infinities (#1869)
• Human monitoring analysis settings: order of settings is incorrect (#1876)
• Do not support multiple urines in analysis, but do allow multiple urines in HBM data (#1877)
• Fix market shares calculation for chronic exposure assessments (#1878)

Open MCRA Core 10.0.8 Update

The attached binary file MCRA.CLI.10.0.8.zip contains the compiled version of the
Open MCRA Command Line Interface, which requires the open source
Microsoft .NET Core 6 runtime
to be installed on your computer.

Version 10.0.8 (2024-02-12)

Added

• Implement data format and use of kinetic conversion factors sub-groups (#1805)
• Extend HBM biomarker conversion calculator with possibility for summation of multiple measured substances (#1837)

Changed

• HBM analysis: change order of settings in output summary (#1839)
• Change all caption upper summaries, use specified percentage (#1859)

Fixed

• ExposurePathway Oral enum was used instead of Dietary enum when running the reverse kinetic model (from internal to external) (#1850)
• Upper MCR plot fix, MCR plots for RPF weighted and sum of ratios corrected x-axes (#1854)
• Update food conversion calculator to be a bit more permissive for market shares not adding up to 100% (allow for minor differences)
• Oxyplot individuals don't render, add uncertainty substances (#1862, #1866, #1867)

Open MCRA Core 10.0.7 Update

The attached binary file MCRA.CLI.zip contains the compiled version of the Open MCRA Command Line Interface, which requires the open source Microsoft .NET Core 6 runtime to be installed on your computer.

Version 10.0.7 (2024-02-02)

Added

• Implement uncertainty distribution kinetic conversion factors (#1845)

Changed

• Move body weight imputation to hbm analysis (#1807)

Fixed

• HBM complete samples should filter on individual day (#1835)
• Violin plots are missing (#1847)