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Welcome to the X-Wing wiki!

Overview of X-Wing

X-Wing (Cross-population Weighting) is a cross-population polygenic prediction framework. It contains three methods:

• LOGODetect(LOcal Genetic cOrrelation DETECTor) (Also see here)
• PANTHER(Polygenic prediction using Bayesian ANnoTation-dependent HorsEshoe Regression)
• LEOPARD(LinEar cOmbination for Polygenic score using gwAs summaRy statistics Data)

The X-Wing software can perform four tasks:

1. Improve genetic risk prediction in ancestrally diverse populations using X-Wing.
2. Identify small genome segments harboring cross-population local genetic correlation signals using LOGODetect.
3. Incorporate annotations into single and cross-population polygenic prediction using PANTHER.
4. Estimate the linear combination weights for multiple PRS by GWAS summary statistics alone using LEOPARD.

Contents of the wiki

• Install X-Wing and prepare the data required.
• Fit X-Wing to improve genetic risk prediction in ancestrally diverse populations.
• Example of fitting X-Wing using real data.