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Gautier Koscielny edited this page Jun 29, 2018 · 7 revisions

Welcome to the BioDataHack_2018 wiki!

Overview

Drug repurposing is the process of identifying potential alternate indications that might benefit from an existing drug. Since existing drugs are already proven to be safe and effective, this approach can have substantial cost savings, and, where related mechanisms underlie disease, can have a greater chance of being effective.

The aim of this hackathon task is to explore using publicly available data to identify and visualise potential drug repurposing opportunities. Simply, starting from an existing approved drug for a disease indication, can you identify diseases that are plausibly related through:

  • shared molecular targets,
  • shared phenotypes,
  • shared curated information,
  • or shared molecular pathways and mechanisms.

We provide data on target and disease relationships including target - disease evidence, the disease ontology we use (Experimental Factor Ontology), similar diseases and similar targets from the Open Targets Platform. We also provide information on approved drugs and drugs in clinical trials with their indications, and networks of relationships between targets based on protein - protein interactions which could be used as a proxy for mechanistic connections.

Data and Documentation

From this page, you will find links to the documentation and examples, specifically:

Further Information

Further information on approaches to repurposing can be found in the following publications and resources:

Some existing examples of repurposed drugs can be found below which could be useful positive controls for your approach.

drug_repurposing_curated.tsv

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