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IndelDollo

An intuitive total-evidence method for combining sequence and structural information in a phylogenetic analysis. This package is still in pre-release and has not yet been published.

BEAST 2 implementation of a stochastic Dollo model where sequence elements are acquired with an acquisition rate, and then mutate down a tree under standard substitution models. The elements can be irreversibly deleted with a loss rate. This model is suitable for biological and linguistic data, and was adapated from the stochastic Dollo model by Nicholls and Gray 2008.

Installation instructions

This package requires BEAST 2.7 or newer

  1. Launch BEAUti
  2. Click on File -> Manage Packages
  3. Install IndelDollo. If IndelDollo is not in the list of packages, you may need to add an extra package repository as follows:

Running IndelDollo

Please see the examples/ folder for working XML files. At this stage, IndelDollo analyses cannot be generated using BEAUti.

Postprocessing

The pruned trees in any given log file may have differing taxonsets. This stumps most of the tree parsers in BEAST2. To summarise a posterior distribution of pruned trees, use the PrunedTreeAnnotator tool in IndelDollo:

path/to/beast/bin/applauncher PrunedTreeAnnotator -burnin 10 -trees in.trees -out mcc.tree

This method first finds the most commonly occurring taxonset, and then finds the maximum clade credibility (mcc) tree among the trees which share that taxonset.

References

Nicholls, Geoff K., and Russell D. Gray. "Dated ancestral trees from binary trait data and their application to the diversification of languages." Journal of the Royal Statistical Society: Series B (Statistical Methodology) 70.3 (2008): 545-566.

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