This is the accompanying code to paper "A Bayesian time-to-event pharmacokinetic model for phase I dose-escalation trials with multiple schedules" by BK Günhan, S Weber, and T Friede. We consider an artificial phase I trial with multiple schedules to illustrate our proposed model TITE-PK.
TITE-PK (a time-to-event pharmacokinetic model) is a method for designing and analyzing phase I dose-escalation trials with multiple schedules, eg a daily and weekly dosing. Hence, TITE-PK finds an acceptable dose and schedule combination.
TITE-PK uses Stan via Rstan, hence it should be installed.
See here
for how to install it.
TITEPK_run.R is the main R-script which produce the Figure 2 of the main text
for TITE-PK methods.
tite_pk.stan is the main Stan script
which is used in TITEPK_run.R to implement the TITE-PK model.
THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
The code was written by Burak Kürsad Günhan and Sebastian Weber. To report any issues or bugs or to suggest enhancements to the package, please go here.