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ejfertig committed Nov 10, 2018
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Expand Up @@ -8,10 +8,10 @@ that preserve the important attributes of the original high dimensional data and
interpretable, searchable features. For transcriptomic data, compressing on the gene
dimension is most attractive: it can be applied to single samples, and genes often provide
information about other co-regulated genes or cellular attributes. We hypothesize that building an ensemble of low dimensional representations across latent space methods will provide a
reduced dimensional space that captures biological sources of variability that is robust to measurement noise. Our seed network will
reduced dimensional space that captures biological sources of variability and is robust to measurement noise. Our seed network will
incorporate biologists and computer scientists from five leading academic institutions who will work together to create foundational technologies
and educational opportunities that promote effective interpretation of low dimensional representations of HCA data. We will continue our active collaborations with other
members of the broader HCA network to integrate state of the art latent space tools, portals, and annotations to enable biological utilization of the resulting low dimensional catalogue of HCA data.
members of the broader HCA network to integrate state of the art latent space tools, portals, and annotations to enable biological utilization of HCA data through latent spaces.

## Scientific Goals

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