In this paper we explore PFAS and OH-PCBs association with risk of multiple sclerosis onset as well as their association with confirmed disability worsening.
The function.R includes all custom functions used in this project. Analysis regarding PFAS/OH-PCBs association with sample collection year, age, sex, and residential area, as well as differential expression analysis and Cox proportional hazard analysis was performed using PFAS_and_OHPCBs_DataAnalysis.Rmd. Cox proportional hazard analysis was performed both in regards to confirmed disability worsening and risk of transitioning from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS). Finally, PFAS/OH-PCBs association with multiple sclerosis onset was analyzed using Risk_of_MS_onset.Rmd.
We thank everyone who helped us in the project. We especially thank all individuals who have participated in the EIMS study. We also acknowledge the Swedish Neuro Registries / Multiple sclerosis.
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