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cgMLST and LINcodes Typing Schemes


Overview

This repository originally contained code to run analyses and generate figures for the:
Pneumococcal Genome Library cgMLST Typing Scheme Manuscript

The same codebase was later adapted to accommodate analyses and create figures for two additional manuscripts:

S. aureus cgMLST Typing Scheme Manuscript
M. catarrhalis cgMLST Typing Scheme Manuscript

Note

To generate the:

  • MST cluster analysis, please refer to: Analysis --> Profile clustering section
  • Pairwise Allelic Mismatches plot, please refer to: Figures --> Figure 2a and 2b
  • Rand Index plot, please refer to: Figures --> Figure 4e

Codebook

This repository contains two main folders: Analysis and Figures.

View folder contents
  1. Analysis - contains the code used to generate:
    1. the distance matrix
    2. the phylogenetic tree
    3. GPSC and Mandrake clustering
  2. Figures - contains the R code used to generate main and supplementary figures

Publications

Publication DOI
MGen 2024 doi
bioRxiv 2025 doi
bioRxiv 2025 doi

Tip

Useful Links for LINcodes

Below are helpful resources to learn more about LINcodes (Life Identification Numbers):
https://pubmed.ncbi.nlm.nih.gov/35700230/
https://www.biorxiv.org/content/10.1101/2024.03.11.584534v1.full

Additional information about how PubMLST deals with LINcodes can be found here BIGSdb documentation chapter 5.24.

Contact

If you have any queries, suggestions or concerns, please contact Angela Brueggemann.

License

Distributed under the GNU General Public License v3.0. Please see LICENSE for more information.

Repository PUBLIC status since: 30/05/2024

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Repository for the pneumococcal cgMLST typing scheme (pneumococcal genome library)

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