In this repository you will find source codes and data sets related to our manuscript:

Deficiency of Heterogeneous Nuclear Ribonucleoprotein U leads to delayed neurogenesis

Francesca Mastropasqua (1,2), Marika Oksanen (1,2), Cristina Soldini (1,2), Shemim Alatar (1,2), Abishek Arora (1,2), Roberto Ballarino (3,4,5), Maya Molinari (6), Federico Agostini (4,5), Axel Poulet (7), Michelle Watts (1,2), Ielyzaveta Rabkina (1,2), Martin Becker (1,2), Danyang Li (1,2), Britt-Marie Anderlid (8,9), Johan Isaksson (1,10), Karl Lundin Remnelius (1), Mohsen Moslem (6), Yannick Jacob (7), Anna Falk (6,11), Nicola Crosetto (3,4,12), Magda Bienko (3,4,12), Emanuela Santini (6), Anders Borgkvist (6), Sven Bölte (1,2,13,14) and Kristiina Tammimies (1,2)*

1 Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institute, Region Stockholm, Stockholm, Sweden.

2 Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Region Stockholm, Stockholm, Sweden

3 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

4 Science for Life Laboratory, Tomtebodavägen 23A, Solna, Sweden

5 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

6 Department of Neuroscience, Karolinska Institutet, Solna, Sweden

7 Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA

8 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

9 Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden

10 Department of Medical Sciences, Child and Adolescent Psychiatry Unit, Uppsala University, Uppsala, Sweden

11 Lund Stem Cell Center, Lund University, Lund, Sweden

12 Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milan, Italy

13 Curtin Autism Research Group, Curtin School of Allied Health, Curtin University, Perth, Western Australia

14 Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

*Correspondence: [email protected]

Published in Biology Open (2023), DOI: 10.1242/bio.060113 | Pubmed: 37815090 | GEO: GSE229004

---

Please note that in the scripts the samples are coded as follows:

• CTRL: CTRL9

• HNRNPUdel/+: ASD

• siHNRNPU: siHNRNPU

• siNTC: siRNActrl