Simple Mendelian Randomization (Simple_MR)

Easy and simple mendelian randomization tool using GWAS summary statistics.

Simple Mendelian Randomization(Simple_MR)

THIS PROGRAM BUILD BY R 3.6 ver

Need R library :

    MendelianRandomization : an R package for performing Mendelian randomization
                            analyses using summarized data. O Yavorska, S Burgess

    MRPRESSO : Detection of widespread horizontal pleiotropy in causal relationships
              inferred from Mendelian randomization between complex traits and diseases.
              Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron D.
              Nature Genetics volume 50, pages693–698(2018)

Require OPTIONS

Option	Require	Discription
-h/ --help	optional	print this help message
-e/ --Exposure	require	Exposure Summary statistics
-o/ --Outcome	require	Outcome Summary statistics
-d/ --OutDIRPrefix	require	Simple MR results out DIR Prefix, Make New Directory, Ansolute Pathway Optional OPTIONS for Exposure LD clumpling
-p --Presso	optional	YES or NO defualt YES, Deletion Outlier use MRPRESSO
-P --plink	optional	plink 1.9 program download by https://www.cog-genomics.org/plink2
-b --bfile	optional	plink input format: .bed .bim .fam prefix

input summary statistic file format :

Any format usefull!

but file head include by SNP,BETA,SE

And White Space Splited data