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enryH committed May 29, 2024
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6 changes: 3 additions & 3 deletions _sources/scripts/2_Run_CLASTER.ipynb
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"cell_type": "markdown",
"metadata": {},
"source": [
"## <center> Training CLASTER <center>\n",
"## Training CLASTER\n",
"The model can be trained by running the following command:\n",
"\n",
"```bash\n",
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"cell_type": "markdown",
"metadata": {},
"source": [
"## <center> Testing CLASTER <center>\n",
"## Testing CLASTER\n",
"\n",
"> _Note:_ \n",
">\n",
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"cell_type": "markdown",
"metadata": {},
"source": [
"## <center> Predicting _in silico_ perturbed chromatin landscapes <center>\n",
"## Predicting _in silico_ perturbed chromatin landscapes\n",
"\n",
">Note: Make sure to create the output folder beforehand: ./runs/perturbation_runs/gene_expression_only_chrom_pure_conv/"
]
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6 changes: 3 additions & 3 deletions _sources/scripts/3_Data_analysis.ipynb
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"cell_type": "markdown",
"metadata": {},
"source": [
"## <center> Model performance on the baseline prediction task <center>\n",
"## Model performance on the baseline prediction task\n",
"**Figure 1 and related supplementary figures**\n",
"\n",
"> Note: ⏰ This took 42 min when analysing all genes and enhancers in chr4:\n",
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"cell_type": "markdown",
"metadata": {},
"source": [
"## <center> _In silico_ perturbations <center>\n",
"## _In silico_ perturbations\n",
"\n",
"**Figure 2 and related supplementary figures**\n",
"\n"
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"cell_type": "markdown",
"metadata": {},
"source": [
"# <center> Attributions <center>\n",
"# Attributions\n",
"\n",
"Now we will compute the attribution scores for every input position (4,10.001) towards every output (401). This mechanism tells how important is every input position (i.e. a given bin in each input track in the landscape or a given bin in a Micro-C matrix) for the prediction of the EU-seq levels at the position described by a given target node (401 targets). It also tells us the direction of the association.\n",
"The original paper can be found at:\n",
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12 changes: 6 additions & 6 deletions index.html
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Expand Up @@ -410,9 +410,9 @@ <h1>Claster<a class="headerlink" href="#claster" title="Link to this heading">#<
<li class="toctree-l1"><a class="reference internal" href="scripts/2_Run_CLASTER.html">2. CREATE &amp; RUN CLASTER</a><ul>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#create-config-files">Create config files:</a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#create-validation-split">Create validation split</a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#training-claster"><center> Training CLASTER <center></a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#testing-claster"><center> Testing CLASTER <center></a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#predicting-in-silico-perturbed-chromatin-landscapes"><center> Predicting <em>in silico</em> perturbed chromatin landscapes <center></a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#training-claster">Training CLASTER</a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#testing-claster">Testing CLASTER</a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/2_Run_CLASTER.html#predicting-in-silico-perturbed-chromatin-landscapes">Predicting <em>in silico</em> perturbed chromatin landscapes</a></li>
</ul>
</li>
<li class="toctree-l1"><a class="reference internal" href="scripts/2b_Run_HyenaDNA_and_Enformer.html">2b. BENCHMARKING CLASTER WITH HYENA-DNA AND ENFORMER</a><ul>
Expand All @@ -423,11 +423,11 @@ <h1>Claster<a class="headerlink" href="#claster" title="Link to this heading">#<
<li class="toctree-l1"><a class="reference internal" href="scripts/3_Data_analysis.html">DATA ANALYSIS NOTEBOOK</a><ul>
<li class="toctree-l2"><a class="reference internal" href="scripts/3_Data_analysis.html#packages">Packages</a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/3_Data_analysis.html#functions">Functions</a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/3_Data_analysis.html#model-performance-on-the-baseline-prediction-task"><center> Model performance on the baseline prediction task <center></a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/3_Data_analysis.html#in-silico-perturbations"><center> <em>In silico</em> perturbations <center></a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/3_Data_analysis.html#model-performance-on-the-baseline-prediction-task">Model performance on the baseline prediction task</a></li>
<li class="toctree-l2"><a class="reference internal" href="scripts/3_Data_analysis.html#in-silico-perturbations"><em>In silico</em> perturbations</a></li>
</ul>
</li>
<li class="toctree-l1"><a class="reference internal" href="scripts/3_Data_analysis.html#attributions"><center> Attributions <center></a></li>
<li class="toctree-l1"><a class="reference internal" href="scripts/3_Data_analysis.html#attributions">Attributions</a></li>
</ul>
</div>
</section>
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18 changes: 9 additions & 9 deletions scripts/2_Run_CLASTER.html
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Expand Up @@ -409,9 +409,9 @@ <h2> Contents </h2>
<ul class="visible nav section-nav flex-column">
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#create-config-files">Create config files:</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#create-validation-split">Create validation split</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#training-claster"><center> Training CLASTER <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#testing-claster"><center> Testing CLASTER <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#predicting-in-silico-perturbed-chromatin-landscapes"><center> Predicting <em>in silico</em> perturbed chromatin landscapes <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#training-claster">Training CLASTER</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#testing-claster">Testing CLASTER</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#predicting-in-silico-perturbed-chromatin-landscapes">Predicting <em>in silico</em> perturbed chromatin landscapes</a></li>
</ul>
</nav>
</div>
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ENSMUSG00000055660.9_rev</p>
</section>
<section id="training-claster">
<h2><center> Training CLASTER <center><a class="headerlink" href="#training-claster" title="Link to this heading">#</a></h2>
<h2>Training CLASTER<a class="headerlink" href="#training-claster" title="Link to this heading">#</a></h2>
<p>The model can be trained by running the following command:</p>
<div class="highlight-bash notranslate"><div class="highlight"><pre><span></span>eirtrain<span class="w"> </span><span class="se">\</span>
--global_configs<span class="w"> </span>./configurations/conf_pure_conv/globals.yaml<span class="w"> </span><span class="se">\</span>
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</div>
</section>
<section id="testing-claster">
<h2><center> Testing CLASTER <center><a class="headerlink" href="#testing-claster" title="Link to this heading">#</a></h2>
<h2>Testing CLASTER<a class="headerlink" href="#testing-claster" title="Link to this heading">#</a></h2>
<blockquote>
<div><p><em>Note:</em></p>
<ol class="arabic simple">
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</div>
</section>
<section id="predicting-in-silico-perturbed-chromatin-landscapes">
<h2><center> Predicting <em>in silico</em> perturbed chromatin landscapes <center><a class="headerlink" href="#predicting-in-silico-perturbed-chromatin-landscapes" title="Link to this heading">#</a></h2>
<h2>Predicting <em>in silico</em> perturbed chromatin landscapes<a class="headerlink" href="#predicting-in-silico-perturbed-chromatin-landscapes" title="Link to this heading">#</a></h2>
<blockquote>
<div><p>Note: Make sure to create the output folder beforehand: ./runs/perturbation_runs/gene_expression_only_chrom_pure_conv/</p>
</div></blockquote>
Expand Down Expand Up @@ -6208,9 +6208,9 @@ <h2><center> Predicting <em>in silico</em> perturbed chromatin landscapes <cente
<ul class="visible nav section-nav flex-column">
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#create-config-files">Create config files:</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#create-validation-split">Create validation split</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#training-claster"><center> Training CLASTER <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#testing-claster"><center> Testing CLASTER <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#predicting-in-silico-perturbed-chromatin-landscapes"><center> Predicting <em>in silico</em> perturbed chromatin landscapes <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#training-claster">Training CLASTER</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#testing-claster">Testing CLASTER</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#predicting-in-silico-perturbed-chromatin-landscapes">Predicting <em>in silico</em> perturbed chromatin landscapes</a></li>
</ul>
</nav></div>

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18 changes: 9 additions & 9 deletions scripts/3_Data_analysis.html
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Expand Up @@ -409,11 +409,11 @@ <h2> Contents </h2>
<li class="toc-h1 nav-item toc-entry"><a class="reference internal nav-link" href="#">DATA ANALYSIS NOTEBOOK</a><ul class="visible nav section-nav flex-column">
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#packages">Packages</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#functions">Functions</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#model-performance-on-the-baseline-prediction-task"><center> Model performance on the baseline prediction task <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#in-silico-perturbations"><center> <em>In silico</em> perturbations <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#model-performance-on-the-baseline-prediction-task">Model performance on the baseline prediction task</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#in-silico-perturbations"><em>In silico</em> perturbations</a></li>
</ul>
</li>
<li class="toc-h1 nav-item toc-entry"><a class="reference internal nav-link" href="#attributions"><center> Attributions <center></center></center></a></li>
<li class="toc-h1 nav-item toc-entry"><a class="reference internal nav-link" href="#attributions">Attributions</a></li>
</ul>

</nav>
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</div>
</section>
<section id="model-performance-on-the-baseline-prediction-task">
<h2><center> Model performance on the baseline prediction task <center><a class="headerlink" href="#model-performance-on-the-baseline-prediction-task" title="Link to this heading">#</a></h2>
<h2>Model performance on the baseline prediction task<a class="headerlink" href="#model-performance-on-the-baseline-prediction-task" title="Link to this heading">#</a></h2>
<p><strong>Figure 1 and related supplementary figures</strong></p>
<blockquote>
<div><p>Note: ⏰ This took 42 min when analysing all genes and enhancers in chr4:</p>
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</div>
</section>
<section id="in-silico-perturbations">
<h2><center> <em>In silico</em> perturbations <center><a class="headerlink" href="#in-silico-perturbations" title="Link to this heading">#</a></h2>
<h2><em>In silico</em> perturbations<a class="headerlink" href="#in-silico-perturbations" title="Link to this heading">#</a></h2>
<p><strong>Figure 2 and related supplementary figures</strong></p>
<blockquote>
<div><p>⏰ The following step takes a few minutes</p>
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</section>
</section>
<section class="tex2jax_ignore mathjax_ignore" id="attributions">
<h1><center> Attributions <center><a class="headerlink" href="#attributions" title="Link to this heading">#</a></h1>
<h1>Attributions<a class="headerlink" href="#attributions" title="Link to this heading">#</a></h1>
<p>Now we will compute the attribution scores for every input position (4,10.001) towards every output (401). This mechanism tells how important is every input position (i.e. a given bin in each input track in the landscape or a given bin in a Micro-C matrix) for the prediction of the EU-seq levels at the position described by a given target node (401 targets). It also tells us the direction of the association.
The original paper can be found at:</p>
<p>https://arxiv.org/abs/1703.01365</p>
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<li class="toc-h1 nav-item toc-entry"><a class="reference internal nav-link" href="#">DATA ANALYSIS NOTEBOOK</a><ul class="visible nav section-nav flex-column">
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#packages">Packages</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#functions">Functions</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#model-performance-on-the-baseline-prediction-task"><center> Model performance on the baseline prediction task <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#in-silico-perturbations"><center> <em>In silico</em> perturbations <center></center></center></a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#model-performance-on-the-baseline-prediction-task">Model performance on the baseline prediction task</a></li>
<li class="toc-h2 nav-item toc-entry"><a class="reference internal nav-link" href="#in-silico-perturbations"><em>In silico</em> perturbations</a></li>
</ul>
</li>
<li class="toc-h1 nav-item toc-entry"><a class="reference internal nav-link" href="#attributions"><center> Attributions <center></center></center></a></li>
<li class="toc-h1 nav-item toc-entry"><a class="reference internal nav-link" href="#attributions">Attributions</a></li>
</ul>

</nav></div>
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2 changes: 1 addition & 1 deletion searchindex.js

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