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Omkar Mohite edited this page Apr 20, 2018 · 2 revisions

Welcome to the minRerouting wiki!


Pipeline for analysis of synthetic lethals in a given model

  • Genome scale metabolic model

  • Check if Synthetic Lethals provided or else run fastSL order 2

  • Generate xlsx file with list of Synthetic Lethals in output folder

  • Run minRerouting with the parameters

  • Generate xlsx for minRerouting data

  • Generate histogram of sizes of minReSets and scatter plot of two path lengths

  • Run clustering of synthetic lethals and generate auto- clustering which can further be curated manually

  • Generate files to be used as input for Cytoscape visualization of minReSets of clusters

  • Run comparison module on two given Synthetic Lethal sets

  • Generate the xlsx file of comparison and histograms

  • Pan species redundancies

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