Nature has evolved the most amazing functional biomolecules and we want to know how they work. Enzymes are the all-purpose catalysts that make the Chemistry of Life run smoothly and efficiently, under the mildest, ‘greenest’ conditions – and protein binders are involved in governing many biological processes.
The Hollfelder group is interested in gaining a fundamental understanding of the principles responsible for molecular recognition processes in chemistry and biology. We probe whether these principles enable us to describe, manipulate and ultimately make functional molecules. Using an eclectic mix of techniques we extend the mechanistic lessons learned to potential applications in biotechnology, synthetic chemistry and medicine.
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How does protein evolution work and where do functional proteins come from?
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Can we explain biological catalysis and molecular recognition in chemical and biophysical terms?
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Where does extreme miniaturisation of experiments (into picoliter droplets made in microfluidic devices) help to answer chemical and biological questions?
Find out more on our website.
If you are looking for some of our older repositories, check out our previous fhlab account.
