diff --git a/bellows/exception.py b/bellows/exception.py
index bbc66203..aa43fddd 100644
--- a/bellows/exception.py
+++ b/bellows/exception.py
@@ -11,3 +11,7 @@ class InvalidCommandError(EzspError):
 
 class ControllerError(ControllerException):
     pass
+
+
+class StackAlreadyRunning(EzspError):
+    pass
diff --git a/bellows/zigbee/application.py b/bellows/zigbee/application.py
index bff3d6e8..80021bf7 100644
--- a/bellows/zigbee/application.py
+++ b/bellows/zigbee/application.py
@@ -32,7 +32,7 @@
     CONFIG_SCHEMA,
     SCHEMA_DEVICE,
 )
-from bellows.exception import ControllerError, EzspError
+from bellows.exception import ControllerError, EzspError, StackAlreadyRunning
 import bellows.ezsp
 from bellows.ezsp.v8.types.named import EmberDeviceUpdate
 import bellows.multicast
@@ -104,7 +104,7 @@ def multicast(self):
 
     async def add_endpoint(self, descriptor: zdo_t.SimpleDescriptor) -> None:
         """Add endpoint."""
-        res = await self._ezsp.addEndpoint(
+        (status,) = await self._ezsp.addEndpoint(
             descriptor.endpoint,
             descriptor.profile,
             descriptor.device_type,
@@ -114,7 +114,8 @@ async def add_endpoint(self, descriptor: zdo_t.SimpleDescriptor) -> None:
             descriptor.input_clusters,
             descriptor.output_clusters,
         )
-        LOGGER.debug("Ezsp adding endpoint: %s", res)
+        if status != t.EmberStatus.SUCCESS:
+            raise StackAlreadyRunning()
 
     async def cleanup_tc_link_key(self, ieee: t.EmberEUI64) -> None:
         """Remove tc link_key for the given device."""
@@ -176,14 +177,20 @@ async def _ensure_network_running(self) -> bool:
     async def start_network(self):
         ezsp = self._ezsp
 
+        try:
+            await self.register_endpoints()
+        except StackAlreadyRunning:
+            # Endpoints can only be registered before the network is up
+            await self._reset()
+            await self.register_endpoints()
+
         await self._ensure_network_running()
 
         if await repairs.fix_invalid_tclk_partner_ieee(ezsp):
             await self._reset()
+            await self.register_endpoints()
             await self._ensure_network_running()
 
-        await self.register_endpoints()
-
         if self.config[zigpy.config.CONF_SOURCE_ROUTING]:
             await ezsp.set_source_routing()
 
diff --git a/tests/test_application.py b/tests/test_application.py
index 27150b4f..c8641bfc 100644
--- a/tests/test_application.py
+++ b/tests/test_application.py
@@ -115,7 +115,7 @@ def aps():
 
 @patch("zigpy.device.Device._initialize", new=AsyncMock())
 @patch("bellows.zigbee.application.ControllerApplication._watchdog", new=AsyncMock())
-async def _test_startup(
+def _create_app_for_startup(
     app,
     nwk_type,
     ieee,
@@ -150,8 +150,8 @@ async def mock_leave(*args, **kwargs):
     ezsp_mock.setConcentrator = AsyncMock()
     ezsp_mock.getTokenData = AsyncMock(return_value=[t.EmberStatus.ERR_FATAL, b""])
     ezsp_mock._command = AsyncMock(return_value=t.EmberStatus.SUCCESS)
-    ezsp_mock.addEndpoint = AsyncMock(return_value=t.EmberStatus.SUCCESS)
-    ezsp_mock.setConfigurationValue = AsyncMock(return_value=t.EmberStatus.SUCCESS)
+    ezsp_mock.addEndpoint = AsyncMock(return_value=[t.EmberStatus.SUCCESS])
+    ezsp_mock.setConfigurationValue = AsyncMock(return_value=[t.EmberStatus.SUCCESS])
     ezsp_mock.networkInit = AsyncMock(return_value=[init])
     ezsp_mock.networkInitExtended = AsyncMock(return_value=[init])
     ezsp_mock.getNetworkParameters = AsyncMock(return_value=[0, nwk_type, nwk_params])
@@ -217,6 +217,23 @@ def form_network():
 
     app.form_network = AsyncMock(side_effect=form_network)
 
+    return ezsp_mock
+
+
+async def _test_startup(
+    app,
+    nwk_type,
+    ieee,
+    auto_form=False,
+    init=0,
+    ezsp_version=4,
+    board_info=True,
+    network_state=t.EmberNetworkStatus.JOINED_NETWORK,
+):
+    ezsp_mock = _create_app_for_startup(
+        app, nwk_type, ieee, auto_form, init, ezsp_version, board_info, network_state
+    )
+
     p1 = patch("bellows.ezsp.EZSP", return_value=ezsp_mock)
     p2 = patch.object(bellows.multicast.Multicast, "startup")
 
@@ -593,9 +610,9 @@ def test_sequence(app):
         assert seq < 256
 
 
-def test_permit_ncp(app):
+async def test_permit_ncp(app):
     app._ezsp.permitJoining = AsyncMock()
-    app.permit_ncp(60)
+    await app.permit_ncp(60)
     assert app._ezsp.permitJoining.call_count == 1
 
 
@@ -1818,12 +1835,47 @@ async def test_connect_failure(
 async def test_repair_tclk_partner_ieee(app: ControllerApplication) -> None:
     """Test that EZSP is reset after repairing TCLK."""
     app._ensure_network_running = AsyncMock()
+    app._reset = AsyncMock()
     app.load_network_info = AsyncMock()
 
+    with patch(
+        "bellows.zigbee.repairs.fix_invalid_tclk_partner_ieee",
+        AsyncMock(return_value=False),
+    ):
+        await app.start_network()
+
+    assert len(app._reset.mock_calls) == 0
+    app._reset.reset_mock()
+
     with patch(
         "bellows.zigbee.repairs.fix_invalid_tclk_partner_ieee",
         AsyncMock(return_value=True),
     ):
         await app.start_network()
 
-    assert len(app._ensure_network_running.mock_calls) == 2
+    assert len(app._reset.mock_calls) == 1
+
+
+async def test_startup_endpoint_register_already_running(
+    app: ControllerApplication, ieee: t.EmberEUI64
+) -> None:
+    """Test that the host is reset before endpoint registration if it is running."""
+
+    app._ezsp = _create_app_for_startup(app, t.EmberNodeType.COORDINATOR, ieee)
+    app._ezsp.addEndpoint = AsyncMock(
+        side_effect=[
+            [t.EmberStatus.INVALID_CALL],  # Fail the first time
+            [t.EmberStatus.SUCCESS],
+            [t.EmberStatus.SUCCESS],
+            [t.EmberStatus.SUCCESS],
+        ]
+    )
+
+    app._reset = AsyncMock()
+
+    with patch.object(bellows.multicast.Multicast, "startup"):
+        await app.start_network()
+
+    assert len(app._reset.mock_calls) == 1
+
+    assert app._ezsp.addEndpoint.call_count >= 3