diff --git a/src/fuzzysearch/_c_ext_base.h b/src/fuzzysearch/_c_ext_base.h
index ffe3083..d94c5cb 100644
--- a/src/fuzzysearch/_c_ext_base.h
+++ b/src/fuzzysearch/_c_ext_base.h
@@ -4,10 +4,6 @@
 #define PY_SSIZE_T_CLEAN
 #include <Python.h>
 
-#if PY_MAJOR_VERSION >= 3
-#define IS_PY3K
-#endif
-
 #ifndef unlikely
     #ifdef __GNUC__
       /* Test for GCC > 2.95 */
diff --git a/src/fuzzysearch/_common.c b/src/fuzzysearch/_common.c
index 5aca022..23b6a5a 100644
--- a/src/fuzzysearch/_common.c
+++ b/src/fuzzysearch/_common.c
@@ -18,12 +18,7 @@ search_exact_byteslike(PyObject *self, PyObject *args, PyObject *kwdict) {
     int subseq_sum;
     char *next_match_ptr;
 
-    const char* argspec =
-#ifdef IS_PY3K
-        "y*y*|ll:search_exact_byteslike";
-#else
-        "s*s*|ll:search_exact_byteslike";
-#endif
+    const char* argspec = "y*y*|ll:search_exact_byteslike";
 
     if (unlikely(!PyArg_ParseTupleAndKeywords(
         args, kwdict,
@@ -88,11 +83,7 @@ search_exact_byteslike(PyObject *self, PyObject *args, PyObject *kwdict) {
 
     while (next_match_ptr != NULL) {
         next_match_index = (const char *)next_match_ptr - seq;
-#ifdef IS_PY3K
         next_result = PyLong_FromLong(next_match_index + start_index);
-#else
-        next_result = PyInt_FromLong(next_match_index + start_index);
-#endif
         if (unlikely(next_result == NULL)) {
             Py_DECREF(results);
             goto error;
@@ -133,12 +124,7 @@ count_differences_with_maximum_byteslike(PyObject *self, PyObject *args)
     Py_ssize_t i;
     int n_differences;
 
-    const char* argspec =
-#ifdef IS_PY3K
-        "y*y*i";
-#else
-        "s*s*i";
-#endif
+    const char* argspec = "y*y*i";
 
     if (!PyArg_ParseTuple(
         args,
@@ -197,8 +183,6 @@ static PyMethodDef _common_methods[] = {
 };
 
 
-#ifdef IS_PY3K
-
 static struct PyModuleDef _common_module = {
    PyModuleDef_HEAD_INIT,
    "_common",   /* name of module */
@@ -213,13 +197,3 @@ PyInit__common(void)
 {
     return PyModule_Create(&_common_module);
 }
-
-#else
-
-PyMODINIT_FUNC
-init_common(void)
-{
-    (void) Py_InitModule("_common", _common_methods);
-}
-
-#endif
diff --git a/src/fuzzysearch/_pymemmem.c b/src/fuzzysearch/_pymemmem.c
index fdc2657..534d32f 100644
--- a/src/fuzzysearch/_pymemmem.c
+++ b/src/fuzzysearch/_pymemmem.c
@@ -2,11 +2,6 @@
 #include "src/fuzzysearch/memmem.h"
 #include "src/fuzzysearch/wordlen_memmem.h"
 
-#if PY_MAJOR_VERSION >= 3
-#define IS_PY3K
-#define PyInt_FromLong PyLong_FromLong
-#endif
-
 
 #ifdef __GNUC__
   /* Test for GCC > 2.95 */
@@ -23,16 +18,6 @@
 #endif /* __GNUC__ */
 
 
-#ifdef IS_PY3K
-    #define ARG_TYPES_DEF "y#y#"
-#else
-    #if PY_HEX_VERSION >= 0x02070000
-        #define ARG_TYPES_DEF "t#t#"
-    #else
-        #define ARG_TYPES_DEF "s#s#"
-    #endif
-#endif
-
 static PyObject *
 py_simple_memmem(PyObject *self, PyObject *args) {
     /* input params */
@@ -44,7 +29,7 @@ py_simple_memmem(PyObject *self, PyObject *args) {
 
     if (unlikely(!PyArg_ParseTuple(
         args,
-        ARG_TYPES_DEF,
+        "y#y#",
         &needle, &needle_len,
         &haystack, &haystack_len
     ))) {
@@ -57,7 +42,7 @@ py_simple_memmem(PyObject *self, PyObject *args) {
         Py_RETURN_NONE;
     }
     else {
-        py_result = PyInt_FromLong(result - haystack);
+        py_result = PyLong_FromLong(result - haystack);
         if (unlikely(py_result == NULL)) {
             return NULL;
         }
@@ -76,7 +61,7 @@ py_wordlen_memmem(PyObject *self, PyObject *args) {
 
     if (unlikely(!PyArg_ParseTuple(
         args,
-        ARG_TYPES_DEF,
+        "y#y#",
         &needle, &needle_len,
         &haystack, &haystack_len
     ))) {
@@ -89,7 +74,7 @@ py_wordlen_memmem(PyObject *self, PyObject *args) {
         Py_RETURN_NONE;
     }
     else {
-        py_result = PyInt_FromLong(result - haystack);
+        py_result = PyLong_FromLong(result - haystack);
         if (unlikely(py_result == NULL)) {
             return NULL;
         }
@@ -109,8 +94,6 @@ static PyMethodDef _pymemmem_methods[] = {
 };
 
 
-#ifdef IS_PY3K
-
 static struct PyModuleDef _pymemmem_module = {
    PyModuleDef_HEAD_INIT,
    "_pymemmem",   /* name of module */
@@ -125,13 +108,3 @@ PyInit__pymemmem(void)
 {
     return PyModule_Create(&_pymemmem_module);
 }
-
-#else
-
-PyMODINIT_FUNC
-init_pymemmem(void)
-{
-    (void) Py_InitModule("_pymemmem", _pymemmem_methods);
-}
-
-#endif
diff --git a/src/fuzzysearch/_substitutions_only.c b/src/fuzzysearch/_substitutions_only.c
index 8135e88..e02170b 100644
--- a/src/fuzzysearch/_substitutions_only.c
+++ b/src/fuzzysearch/_substitutions_only.c
@@ -17,9 +17,6 @@
 #undef DECLARE_VARS
 
 
-#ifdef IS_PY3K
-#define PyInt_FromSsize_t(x) PyLong_FromSsize_t(x)
-#endif
 #define DECLARE_VARS       \
     PyObject *results;     \
     PyObject *next_result
@@ -28,7 +25,7 @@
     if (unlikely(!results))  \
         goto error;
 #define OUTPUT_VALUE(x) do {                                           \
-    next_result = PyInt_FromSsize_t((x));                              \
+    next_result = PyLong_FromSsize_t((x));                             \
     if (unlikely(next_result == NULL)) {                               \
         Py_DECREF(results);                                            \
         goto error;                                                    \
@@ -74,8 +71,6 @@ static PyMethodDef substitutions_only_methods[] = {
 };
 
 
-#ifdef IS_PY3K
-
 static struct PyModuleDef substitutions_only_module = {
    PyModuleDef_HEAD_INIT,
    "_substitutions_only",   /* name of module */
@@ -90,13 +85,3 @@ PyInit__substitutions_only(void)
 {
     return PyModule_Create(&substitutions_only_module);
 }
-
-#else
-
-PyMODINIT_FUNC
-init_substitutions_only(void)
-{
-    (void) Py_InitModule("_substitutions_only", substitutions_only_methods);
-}
-
-#endif
diff --git a/src/fuzzysearch/_substitutions_only_lp_template.h b/src/fuzzysearch/_substitutions_only_lp_template.h
index 1111eca..7da3ff2 100644
--- a/src/fuzzysearch/_substitutions_only_lp_template.h
+++ b/src/fuzzysearch/_substitutions_only_lp_template.h
@@ -18,12 +18,7 @@ FUNCTION_NAME(PyObject *self, PyObject *args)
 
     DECLARE_VARS;
 
-    const char* argspec =
-#ifdef IS_PY3K
-        "y*y*i";
-#else
-        "s*s*i";
-#endif
+    const char* argspec = "y*y*i";
 
     if (unlikely(!PyArg_ParseTuple(
         args,
diff --git a/src/fuzzysearch/_substitutions_only_ngrams_template.h b/src/fuzzysearch/_substitutions_only_ngrams_template.h
index dc65815..462ac01 100644
--- a/src/fuzzysearch/_substitutions_only_ngrams_template.h
+++ b/src/fuzzysearch/_substitutions_only_ngrams_template.h
@@ -24,12 +24,7 @@ FUNCTION_NAME(PyObject *self, PyObject *args)
 
     DECLARE_VARS;
 
-    const char* argspec =
-#ifdef IS_PY3K
-        "y*y*i";
-#else
-        "s*s*i";
-#endif
+    const char* argspec = "y*y*i";
 
     if (unlikely(!PyArg_ParseTuple(
         args,