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Filtering lower-case letters from pileup? #27

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stschiff opened this issue Jul 21, 2022 · 0 comments
Open

Filtering lower-case letters from pileup? #27

stschiff opened this issue Jul 21, 2022 · 0 comments

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@stschiff
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v1.5.2 introduced a feature whereby lower-case letters in the pileup-input are automatically parsed as capital-letters and thereby fully considered when calling the alleles. This may be appropriate in many cases, but sometimes lower-case letters signify lower-quality or masked reads, so there may be a point to not parse these.

We might want an option to ignore lower-letter reads.

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