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euromix.sbml
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euromix.sbml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version2/core" level="3" version="2">
<model metaid="euromix" id="euromix" substanceUnits="MilliMOL" timeUnits="HR" volumeUnits="L">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#euromix">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/mamo/MAMO_0000203"/>
<rdf:li rdf:resource="http://identifiers.org/mamo/MAMO_0000046"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:hasTaxon>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/taxonomy/40674"/>
</rdf:Bag>
</bqbiol:hasTaxon>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfFunctionDefinitions>
<functionDefinition id="conc">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> q </ci>
</bvar>
<bvar>
<ci> vol </ci>
</bvar>
<piecewise>
<piece>
<apply>
<divide/>
<ci> q </ci>
<ci> vol </ci>
</apply>
<apply>
<gt/>
<ci> vol </ci>
<cn type="e-notation"> 1 <sep/> -5 </cn>
</apply>
</piece>
<otherwise>
<cn type="integer"> 0 </cn>
</otherwise>
</piecewise>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="metab_MM">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> Vmax </ci>
</bvar>
<bvar>
<ci> Km </ci>
</bvar>
<bvar>
<ci> PC </ci>
</bvar>
<bvar>
<ci> q </ci>
</bvar>
<bvar>
<ci> vol </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> vol </ci>
<ci> Vmax </ci>
<apply>
<ci> conc </ci>
<ci> q </ci>
<ci> vol </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> PC </ci>
<ci> Km </ci>
</apply>
<apply>
<ci> conc </ci>
<ci> q </ci>
<ci> vol </ci>
</apply>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="metab_MA">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> CLH </ci>
</bvar>
<bvar>
<ci> PC </ci>
</bvar>
<bvar>
<ci> q </ci>
</bvar>
<bvar>
<ci> vol </ci>
</bvar>
<apply>
<divide/>
<apply>
<times/>
<ci> CLH </ci>
<apply>
<ci> conc </ci>
<ci> q </ci>
<ci> vol </ci>
</apply>
</apply>
<ci> PC </ci>
</apply>
</lambda>
</math>
</functionDefinition>
</listOfFunctionDefinitions>
<listOfUnitDefinitions>
<unitDefinition id="MilliMOL">
<listOfUnits>
<unit kind="mole" exponent="1" scale="-3" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="HR">
<listOfUnits>
<unit kind="second" exponent="1" scale="0" multiplier="3600"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="L">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="KiloGM">
<listOfUnits>
<unit kind="gram" exponent="1" scale="3" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="DeciM2">
<listOfUnits>
<unit kind="metre" exponent="2" scale="-1" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="DeciM">
<listOfUnits>
<unit kind="metre" exponent="1" scale="-1" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="UNITLESS">
<listOfUnits>
<unit kind="dimensionless" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="L_PER_KiloGM_HR">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
<unit kind="second" exponent="-1" scale="1" multiplier="3600"/>
<unit kind="gram" exponent="-1" scale="3" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="L_PER_HR">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
<unit kind="second" exponent="-1" scale="1" multiplier="3600"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="KiloGM_PER_L">
<listOfUnits>
<unit kind="gram" exponent="1" scale="3" multiplier="1"/>
<unit kind="litre" exponent="-1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MilliMOL_PER_L_HR">
<listOfUnits>
<unit kind="mole" exponent="1" scale="-3" multiplier="1"/>
<unit kind="second" exponent="-1" scale="1" multiplier="3600"/>
<unit kind="litre" exponent="-1" scale="3" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="DeciM_PER_HR">
<listOfUnits>
<unit kind="metre" exponent="1" scale="-1" multiplier="1"/>
<unit kind="second" exponent="-1" scale="1" multiplier="3600"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="PER_H">
<listOfUnits>
<unit kind="second" exponent="-1" scale="1" multiplier="3600"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment metaid="meta_Air" id="Air" name="alveolar air" spatialDimensions="3" size="1" units="L" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Air">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00458"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/NCIT_C150891"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Urine" id="Urine" name="urine" spatialDimensions="3" size="1" units="L" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Urine">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001088"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Fat" id="Fat" name="adipose tissue" spatialDimensions="3" size="14.63" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Fat">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001013"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Rich" id="Rich" name="richly perfused tissue" spatialDimensions="3" size="7.35" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Rich">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00464"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0013756"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Liver" id="Liver" name="liver" spatialDimensions="3" size="1.68" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Liver">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002107"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Art" id="Art" name="arterial blood" spatialDimensions="3" size="1.58666666666667" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Art">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00462"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0013755"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Ven" id="Ven" name="venous blood" spatialDimensions="3" size="3.17333333333333" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Ven">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00463"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0013756"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Skin_e" id="Skin_e" name="viable epidermis exposed skin" spatialDimensions="3" size="0.2318" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Skin_e">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00467"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002097"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Skin_u" id="Skin_u" name="viable epidermis unexposed skin" spatialDimensions="3" size="2.0862" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Skin_u">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00466"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002097"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Skin_sc_e" id="Skin_sc_e" name="stratum corneum exposed skin" spatialDimensions="3" size="0.0019" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Skin_sc_e">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00469"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002027"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Skin_sc_u" id="Skin_sc_u" name="stratum corneum unexposed skin" spatialDimensions="3" size="0.0171" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Skin_sc_u">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00468"/>
</rdf:Bag>
</bqmodel:is>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0002027"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Poor" id="Poor" name="poorly perfused tissue" spatialDimensions="3" size="32.243" units="L" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Poor">
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00465"/>
</rdf:Bag>
</bqmodel:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
<compartment metaid="meta_Gut" id="Gut" name="gut" spatialDimensions="3" size="1" units="L" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Gut">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001555"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species metaid="meta_QFat" sboTerm="SBO:0000247" id="QFat" name="quantity in fat tissues" compartment="Fat" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QFat">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QRich" sboTerm="SBO:0000247" id="QRich" name="quantity in richly tissues" compartment="Rich" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QRich">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QPoor" sboTerm="SBO:0000247" id="QPoor" name="quantity in poor tissues" compartment="Poor" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QPoor">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QLiver" sboTerm="SBO:0000247" id="QLiver" name="quantity in liver" compartment="Liver" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QLiver">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QMetab" id="QMetab" name="quantity metabolized (cumulated)" compartment="Liver" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QMetab">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/CHEBI:25212"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QGut" sboTerm="SBO:0000247" id="QGut" name="quantity in gut lumen" compartment="Gut" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QGut">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QSkin_u" sboTerm="SBO:0000247" id="QSkin_u" name="quantity in viable skin (unexposed)" compartment="Skin_u" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QSkin_u">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QSkin_e" sboTerm="SBO:0000247" id="QSkin_e" name="quantity in viable skin (exposed)" compartment="Skin_e" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QSkin_e">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QSkin_sc_u" sboTerm="SBO:0000247" id="QSkin_sc_u" name="quantity in skin stratum corneum (unexposed)" compartment="Skin_sc_u" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QSkin_sc_u">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QSkin_sc_e" sboTerm="SBO:0000247" id="QSkin_sc_e" name="quantity in skin stratum corneum (exposed)" compartment="Skin_sc_e" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QSkin_sc_e">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QArt" sboTerm="SBO:0000247" id="QArt" name="quantity in arterial blood" compartment="Art" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QArt">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QVen" sboTerm="SBO:0000247" id="QVen" name="quantity in venous blood" compartment="Ven" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QVen">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QExcret" sboTerm="SBO:0000247" id="QExcret" name="quantity excreted in urine (cumulated)" compartment="Urine" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QExcret">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
<species metaid="meta_QAir" sboTerm="SBO:0000247" id="QAir" name="quantity in air" compartment="Air" initialAmount="0" substanceUnits="MilliMOL" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_QAir">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://identifiers.org/SBO:0000247"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</species>
</listOfSpecies>
<listOfParameters>
<parameter metaid="meta_BM" id="BM" name="body mass" value="70" units="KiloGM" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_BM">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00009"/>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/NCIT_C81328"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_BSA" id="BSA" name="body surface area" value="190" units="DeciM2" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_BSA">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00011"/>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/NCIT_C25157"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_Height_sc" id="Height_sc" name="thickness stratum corneum" value="0.0001" units="DeciM" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Height_sc">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_Height_vs" id="Height_vs" name="thickness viable epidermis" value="0.0122" units="DeciM" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Height_vs">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scVFat" id="scVFat" name="fat as fraction of total body volume" value="0.209" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scVFat">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scVRich" id="scVRich" name="richly perfused tissues as fraction of total body volume" value="0.105" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scVRich">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scVLiver" id="scVLiver" name="liver as fraction of total body volume" value="0.024" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scVLiver">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scVBlood" id="scVBlood" name="blood as fraction of total body volume" value="0.068" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scVBlood">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scFBlood" id="scFBlood" name="total blood flow per unit mass" value="4.8" units="L_PER_KiloGM_HR" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scFBlood">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scFFat" id="scFFat" name="fat fraction of total blood flow going to compartments" value="0.085" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scFFat">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scFPoor" id="scFPoor" name="poorly perfused tissues fraction of total blood flow going to compartments" value="0.12" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scFPoor">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scFLiver" id="scFLiver" name="liver fraction of total blood flow going to compartments" value="0.27" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scFLiver">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_scFSkin" id="scFSkin" name="skin fraction of total blood flow going to compartments" value="0.05" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_scFSkin">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_Falv" id="Falv" name="alveolar ventilation rate" value="2220" units="L_PER_HR" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Falv">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00115"/>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_rho" id="rho" name="tissue density" value="1" units="KiloGM_PER_L" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_rho">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_PCFat" id="PCFat" name="partition coefficient fat over blood" value="2.53" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_PCFat">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00167"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_PCLiver" id="PCLiver" name="partition coefficient liver over blood" value="0.923" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_PCLiver">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00167"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_PCRich" id="PCRich" name="partition coefficient poorly perfused tissue over blood" value="0.875" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_PCRich">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00167"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_PCPoor" id="PCPoor" name="partition coefficient richly perfused tissue over blood" value="0.647" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_PCPoor">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00167"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_PCSkin_sc" id="PCSkin_sc" name="partition coefficient viable skin over stratum corneum" value="0.889" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_PCSkin_sc">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00167"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_PCSkin" id="PCSkin" name="partition coefficient viable skin over blood" value="0.889" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_PCSkin">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00167"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_PCAir" id="PCAir" name="partition coefficient blood over air" value="1e+99" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_PCAir">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00167"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_Km" id="Km" name="Michaelis constant" value="0" units="MilliMOL" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Km">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00216"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter id="Michaelis" name="flag for Michaelis-Menten or linear metabolism" value="0" units="UNITLESS" constant="true"/>
<parameter metaid="meta_Vmax" id="Vmax" name="maximum rate of metabolism" value="0" units="MilliMOL_PER_L_HR" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Vmax">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00215"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_fub" id="fub" name="unbound fraction in blood" value="0.51" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_fub">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00151"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_fSA_exposed" id="fSA_exposed" name="fraction of skin surface area actually exposed" value="0.1" units="UNITLESS" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_fSA_exposed">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_Kp_sc_vs" id="Kp_sc_vs" name="diffusion rate from stratum corneum to viable skin" value="0.01" units="DeciM_PER_HR" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Kp_sc_vs">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_kGut" id="kGut" name="oral absorption rate constant" value="1" units="PER_H" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_kGut">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_CLH" id="CLH" name="hepatic clearance rate" value="132" units="L_PER_HR" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_CLH">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/OMIT_0009720"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_Ke" id="Ke" name="renal excretion rate" value="7.5" units="L_PER_HR" constant="true">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_Ke">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00240"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>
</parameter>
<parameter metaid="meta_f_su" id="f_su" value="1.71" units="L_PER_HR" constant="false">
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#meta_f_su">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://purl.obolibrary.org/obo/PBPKO_00007"/>