diff --git a/.changeset/tiny-zebras-stare.md b/.changeset/tiny-zebras-stare.md
new file mode 100644
index 00000000000..89b99976362
--- /dev/null
+++ b/.changeset/tiny-zebras-stare.md
@@ -0,0 +1,5 @@
+---
+"@remix-run/server-runtime": minor
+---
+
+Deprecate `SerializeFrom` in favor of generics because it will be removed in React Router v7
diff --git a/packages/remix-server-runtime/serialize.ts b/packages/remix-server-runtime/serialize.ts
index 99512790979..9f417d68e26 100644
--- a/packages/remix-server-runtime/serialize.ts
+++ b/packages/remix-server-runtime/serialize.ts
@@ -21,6 +21,11 @@ type SingleFetchEnabled =
  *
  * For example:
  * `type LoaderData = SerializeFrom<typeof loader>`
+ *
+ * @deprecated SerializeFrom is deprecated and will be removed in React Router
+ * v7. Please use the generics on `useLoaderData`/etc. instead of manually
+ * deserializing in Remix v2.  You can convert to the generated types once you
+ * migrate to React Router v7.
  */
 export type SerializeFrom<T> =
   SingleFetchEnabled extends true ? SingleFetch_SerializeFrom<T> :