diff --git a/mypyc/irbuild/function.py b/mypyc/irbuild/function.py
index 7303f561d60c..0cf0edb32f86 100644
--- a/mypyc/irbuild/function.py
+++ b/mypyc/irbuild/function.py
@@ -540,7 +540,11 @@ def handle_ext_method(builder: IRBuilder, cdef: ClassDef, fdef: FuncDef) -> None
     # children.
     if class_ir.allow_interpreted_subclasses:
         f = gen_glue(builder, func_ir.sig, func_ir, class_ir, class_ir, fdef, do_py_ops=True)
-        class_ir.glue_methods[(class_ir, name)] = f
+        # Use func_ir.decl.name (unique) rather than fdef.name, because for properties
+        # the getter and setter share the same fdef.name but have distinct decl names
+        # (e.g. "prop" vs "__mypyc_setter__prop"). Using fdef.name would cause the
+        # setter's glue to overwrite the getter's glue in the shadow vtable.
+        class_ir.glue_methods[(class_ir, func_ir.decl.name)] = f
         builder.functions.append(f)
 
     if fdef.name == "__getattr__":
@@ -653,8 +657,9 @@ def gen_glue(
     """
     if fdef.is_property:
         return gen_glue_property(builder, base_sig, target, cls, base, fdef.line, do_py_ops)
-    else:
-        return gen_glue_method(builder, base_sig, target, cls, base, fdef.line, do_py_ops)
+    if do_py_ops and target.name.startswith(PROPSET_PREFIX):
+        return gen_glue_property_setter(builder, base_sig, target, cls, base, fdef.line)
+    return gen_glue_method(builder, base_sig, target, cls, base, fdef.line, do_py_ops)
 
 
 class ArgInfo(NamedTuple):
@@ -846,6 +851,56 @@ def gen_glue_property(
     )
 
 
+def gen_glue_property_setter(
+    builder: IRBuilder, sig: FuncSignature, target: FuncIR, cls: ClassIR, base: ClassIR, line: int
+) -> FuncIR:
+    """Generate a shadow glue method for a property setter.
+
+    For interpreted subclasses, property setters can't be called via the
+    internal __mypyc_setter__<name> method. Instead, use Python's setattr
+    to set the property via the standard descriptor protocol.
+    """
+    builder.enter()
+    builder.ret_types[-1] = sig.ret_type
+
+    rt_args = list(sig.args)
+    rt_args[0] = RuntimeArg(sig.args[0].name, RInstance(cls))
+
+    arg_info = get_args(builder, rt_args, line)
+    args = arg_info.args
+
+    self_arg = args[0]
+    value_arg = args[1]
+
+    # Extract the property name from "__mypyc_setter__<name>"
+    assert target.name.startswith(PROPSET_PREFIX)
+    prop_name = target.name[len(PROPSET_PREFIX) :]
+
+    builder.primitive_op(
+        py_setattr_op,
+        [
+            self_arg,
+            builder.load_str(prop_name),
+            builder.coerce(value_arg, object_rprimitive, line),
+        ],
+        line,
+    )
+    retval = builder.coerce(builder.none(), sig.ret_type, line)
+    builder.add(Return(retval))
+
+    arg_regs, _, blocks, return_type, _ = builder.leave()
+    return FuncIR(
+        FuncDecl(
+            target.name + "__" + base.name + "_glue",
+            cls.name,
+            builder.module_name,
+            FuncSignature(rt_args, return_type),
+        ),
+        arg_regs,
+        blocks,
+    )
+
+
 def get_func_target(builder: IRBuilder, fdef: FuncDef) -> AssignmentTarget:
     """Given a FuncDef, return the target for the instance of its callable class.
 
diff --git a/mypyc/test-data/irbuild-glue-methods.test b/mypyc/test-data/irbuild-glue-methods.test
index 35e6be1283eb..87b3bf7fee58 100644
--- a/mypyc/test-data/irbuild-glue-methods.test
+++ b/mypyc/test-data/irbuild-glue-methods.test
@@ -453,3 +453,59 @@ class EE(E):
 main:7: error: An argument with type "i64" cannot be given a default value in a method override
 main:13: error: Incompatible argument type "i64" (base class has type "int")
 main:18: error: Incompatible argument type "int" (base class has type "i64")
+
+[case testPropertySetterShadowGlue]
+import mypy_extensions
+
+@mypy_extensions.mypyc_attr(allow_interpreted_subclasses=True)
+class Base:
+    _x: str = ""
+
+    @property
+    def x(self) -> str:
+        return self._x
+
+    @x.setter
+    def x(self, v: str) -> None:
+        self._x = v
+[out]
+def Base.x(self):
+    self :: __main__.Base
+    r0 :: str
+L0:
+    r0 = self._x
+    return r0
+def Base.x__Base_glue(__mypyc_self__):
+    __mypyc_self__ :: __main__.Base
+    r0 :: str
+    r1 :: object
+    r2 :: str
+L0:
+    r0 = 'x'
+    r1 = CPyObject_GetAttr(__mypyc_self__, r0)
+    r2 = cast(str, r1)
+    return r2
+def Base.__mypyc_setter__x(self, v):
+    self :: __main__.Base
+    v :: str
+    r0 :: bool
+L0:
+    self._x = v; r0 = is_error
+    return 1
+def Base.__mypyc_setter__x__Base_glue(self, v):
+    self :: __main__.Base
+    v, r0 :: str
+    r1 :: i32
+    r2 :: bit
+L0:
+    r0 = 'x'
+    r1 = PyObject_SetAttr(self, r0, v)
+    r2 = r1 >= 0 :: signed
+    return 1
+def Base.__mypyc_defaults_setup(__mypyc_self__):
+    __mypyc_self__ :: __main__.Base
+    r0 :: str
+L0:
+    r0 = ''
+    __mypyc_self__._x = r0
+    return 1
diff --git a/mypyc/test-data/run-classes.test b/mypyc/test-data/run-classes.test
index 54e568a47768..0c1557b9eed9 100644
--- a/mypyc/test-data/run-classes.test
+++ b/mypyc/test-data/run-classes.test
@@ -5774,3 +5774,43 @@ from native import Concrete
 c = Concrete()
 assert c.value() == 42
 assert c.derived() == 42
+
+[case testPropertyShadowVtableGlue]
+from typing import List
+import mypy_extensions
+
+@mypy_extensions.mypyc_attr(allow_interpreted_subclasses=True)
+class Base:
+    _x: str
+    _y: List[int]
+    def __init__(self) -> None:
+        self._x = ""
+        self._y = []
+
+    @property
+    def x(self) -> str:
+        return self._x
+
+    @x.setter
+    def x(self, v: str) -> None:
+        self._x = v
+
+    @property
+    def y(self) -> List[int]:
+        return self._y
+
+    @y.setter
+    def y(self, v: List[int]) -> None:
+        self._y = v
+
+    def method(self) -> str:
+        self.x = "a"
+        self.y = [1]
+        return self.x + str(len(self.y))
+
+[file driver.py]
+from native import Base
+
+Sub = type("Sub", (Base,), {})
+s = Sub()
+assert s.method() == "a1"