diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 13e1cf7d7..ff1a42f28 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -2,7 +2,9 @@ ci:
   autofix_prs: true
   autoupdate_schedule: weekly
   submodules: false
-  skip: [regenerate-files]
+  # pip-compile requires internet, regenerate-files may get cache
+  # issues in CI, so they're run in check.sh
+  skip: [pip-compile, regenerate-files]
 
 repos:
   - repo: https://github.com/pre-commit/pre-commit-hooks
@@ -44,7 +46,30 @@ repos:
     hooks:
       - id: regenerate-files
         name: regenerate generated files
-        language: system
+        language: python
         entry: python src/trio/_tools/gen_exports.py
         pass_filenames: false
+        additional_dependencies: ["astor", "attrs", "black", "ruff"]
         files: ^src\/trio\/_core\/(_run|(_i(o_(common|epoll|kqueue|windows)|nstrumentation)))\.py$
+  - repo: https://github.com/astral-sh/uv-pre-commit
+    rev: 0.5.9
+    hooks:
+      # Compile requirements
+      - id: pip-compile
+        name: uv pip-compile test-requirements.in
+        args: [
+          "--universal",
+          "--python-version=3.9",
+          "test-requirements.in",
+          "-o",
+          "test-requirements.txt"]
+        files: ^test-requirements\.(in|txt)$
+      - id: pip-compile
+        name: uv pip-compile docs-requirements.in
+        args: [
+          "--universal",
+          "--python-version=3.11",
+          "docs-requirements.in",
+          "-o",
+          "docs-requirements.txt"]
+        files: ^docs-requirements\.(in|txt)$
diff --git a/check.sh b/check.sh
index b65967596..701db8ce6 100755
--- a/check.sh
+++ b/check.sh
@@ -17,38 +17,6 @@ python ./src/trio/_tools/gen_exports.py --test \
     || EXIT_STATUS=$?
 echo "::endgroup::"
 
-# Autoformatter *first*, to avoid double-reporting errors
-# (we'd like to run further autoformatters but *after* merging;
-# see https://forum.bors.tech/t/pre-test-and-pre-merge-hooks/322)
-# autoflake --recursive --in-place .
-# pyupgrade --py3-plus $(find . -name "*.py")
-echo "::group::Black"
-if ! black --check src/trio; then
-    echo "* Black found issues" >> "$GITHUB_STEP_SUMMARY"
-    EXIT_STATUS=1
-    black --diff src/trio
-    echo "::endgroup::"
-    echo "::error:: Black found issues"
-else
-    echo "::endgroup::"
-fi
-
-# Run ruff, configured in pyproject.toml
-echo "::group::Ruff"
-if ! ruff check .; then
-    echo "* ruff found issues." >> "$GITHUB_STEP_SUMMARY"
-    EXIT_STATUS=1
-    if $ON_GITHUB_CI; then
-        ruff check --output-format github --diff .
-    else
-        ruff check --diff .
-    fi
-    echo "::endgroup::"
-    echo "::error:: ruff found issues"
-else
-    echo "::endgroup::"
-fi
-
 # Run mypy on all supported platforms
 # MYPY is set if any of them fail.
 MYPY=0
@@ -77,25 +45,11 @@ if [ $MYPY -ne 0 ]; then
 fi
 
 # Check pip compile is consistent
-echo "::group::Pip Compile - Tests"
-uv pip compile --universal --python-version=3.9 test-requirements.in -o test-requirements.txt
-echo "::endgroup::"
-echo "::group::Pip Compile - Docs"
-uv pip compile --universal --python-version=3.11 docs-requirements.in -o docs-requirements.txt
+echo "::group::Pip Compile - Tests & Docs"
+pre-commit run pip-compile --all-files \
+    || EXIT_STATUS=$?
 echo "::endgroup::"
 
-if git status --porcelain | grep -q "requirements.txt"; then
-    echo "::error::requirements.txt changed."
-    echo "::group::requirements.txt changed"
-    echo "* requirements.txt changed" >> "$GITHUB_STEP_SUMMARY"
-    git status --porcelain
-    git --no-pager diff --color ./*requirements.txt
-    EXIT_STATUS=1
-    echo "::endgroup::"
-fi
-
-codespell || EXIT_STATUS=$?
-
 echo "::group::Pyright interface tests"
 python src/trio/_tests/check_type_completeness.py || EXIT_STATUS=$?
 
@@ -113,8 +67,7 @@ Problems were found by static analysis (listed above).
 To fix formatting and see remaining errors, run
 
     uv pip install -r test-requirements.txt
-    black src/trio
-    ruff check src/trio
+    pre-commit run --all-files
     ./check.sh
 
 in your local checkout.
diff --git a/docs-requirements.txt b/docs-requirements.txt
index 03cefbc9a..5764bd9c6 100644
--- a/docs-requirements.txt
+++ b/docs-requirements.txt
@@ -12,7 +12,7 @@ beautifulsoup4==4.12.3
     # via sphinx-codeautolink
 certifi==2024.8.30
     # via requests
-cffi==1.17.1 ; platform_python_implementation != 'PyPy' or os_name == 'nt'
+cffi==1.17.1 ; os_name == 'nt' or platform_python_implementation != 'PyPy'
     # via
     #   -r docs-requirements.in
     #   cryptography
@@ -20,7 +20,7 @@ charset-normalizer==3.4.0
     # via requests
 click==8.1.7
     # via towncrier
-colorama==0.4.6 ; sys_platform == 'win32' or platform_system == 'Windows'
+colorama==0.4.6 ; platform_system == 'Windows' or sys_platform == 'win32'
     # via
     #   click
     #   sphinx
@@ -51,7 +51,7 @@ outcome==1.3.0.post0
     # via -r docs-requirements.in
 packaging==24.2
     # via sphinx
-pycparser==2.22 ; platform_python_implementation != 'PyPy' or os_name == 'nt'
+pycparser==2.22 ; os_name == 'nt' or platform_python_implementation != 'PyPy'
     # via cffi
 pygments==2.18.0
     # via sphinx
diff --git a/test-requirements.in b/test-requirements.in
index 809e171e3..2e29cda42 100644
--- a/test-requirements.in
+++ b/test-requirements.in
@@ -17,6 +17,7 @@ ruff >= 0.8.0
 astor          # code generation
 uv >= 0.2.24
 codespell
+pre-commit
 
 # https://github.com/python-trio/trio/pull/654#issuecomment-420518745
 mypy-extensions
diff --git a/test-requirements.txt b/test-requirements.txt
index a5c17a256..351e3fc17 100644
--- a/test-requirements.txt
+++ b/test-requirements.txt
@@ -18,17 +18,19 @@ black==24.10.0 ; implementation_name == 'cpython'
     # via -r test-requirements.in
 certifi==2024.8.30
     # via requests
-cffi==1.17.1 ; platform_python_implementation != 'PyPy' or os_name == 'nt'
+cffi==1.17.1 ; os_name == 'nt' or platform_python_implementation != 'PyPy'
     # via
     #   -r test-requirements.in
     #   cryptography
+cfgv==3.4.0
+    # via pre-commit
 charset-normalizer==3.4.0
     # via requests
 click==8.1.7 ; implementation_name == 'cpython'
     # via black
 codespell==2.3.0
     # via -r test-requirements.in
-colorama==0.4.6 ; (implementation_name != 'cpython' and sys_platform == 'win32') or (platform_system != 'Windows' and sys_platform == 'win32') or (implementation_name == 'cpython' and platform_system == 'Windows')
+colorama==0.4.6 ; (implementation_name == 'cpython' and platform_system == 'Windows') or sys_platform == 'win32'
     # via
     #   click
     #   pylint
@@ -44,12 +46,18 @@ cryptography==43.0.3
     #   types-pyopenssl
 dill==0.3.9
     # via pylint
+distlib==0.3.9
+    # via virtualenv
 docutils==0.21.2
     # via sphinx
 exceptiongroup==1.2.2 ; python_full_version < '3.11'
     # via
     #   -r test-requirements.in
     #   pytest
+filelock==3.16.1
+    # via virtualenv
+identify==2.6.3
+    # via pre-commit
 idna==3.10
     # via
     #   -r test-requirements.in
@@ -79,7 +87,9 @@ mypy-extensions==1.0.0
     #   black
     #   mypy
 nodeenv==1.9.1
-    # via pyright
+    # via
+    #   pre-commit
+    #   pyright
 orjson==3.10.12 ; implementation_name == 'cpython'
     # via -r test-requirements.in
 outcome==1.3.0.post0
@@ -97,9 +107,12 @@ platformdirs==4.3.6
     # via
     #   black
     #   pylint
+    #   virtualenv
 pluggy==1.5.0
     # via pytest
-pycparser==2.22 ; platform_python_implementation != 'PyPy' or os_name == 'nt'
+pre-commit==4.0.1
+    # via -r test-requirements.in
+pycparser==2.22 ; os_name == 'nt' or platform_python_implementation != 'PyPy'
     # via cffi
 pygments==2.18.0
     # via sphinx
@@ -111,6 +124,8 @@ pyright==1.1.389
     # via -r test-requirements.in
 pytest==8.3.3
     # via -r test-requirements.in
+pyyaml==6.0.2
+    # via pre-commit
 requests==2.32.3
     # via sphinx
 ruff==0.8.4
@@ -168,5 +183,7 @@ urllib3==2.2.3
     # via requests
 uv==0.5.5
     # via -r test-requirements.in
+virtualenv==20.28.0
+    # via pre-commit
 zipp==3.21.0 ; python_full_version < '3.10'
     # via importlib-metadata