diff --git a/injectproxy/routes.go b/injectproxy/routes.go
index 266d3226..09a397ee 100644
--- a/injectproxy/routes.go
+++ b/injectproxy/routes.go
@@ -49,10 +49,12 @@ type routes struct {
 }
 
 type options struct {
-	enableLabelAPIs  bool
-	passthroughPaths []string
-	errorOnReplace   bool
-	registerer       prometheus.Registerer
+	enableLabelAPIs   bool
+	passthroughPaths  []string
+	errorOnReplace    bool
+	registerer        prometheus.Registerer
+	extraHttpHeaders  map[string]string
+	rewriteHostHeader string
 }
 
 type Option interface {
@@ -96,6 +98,18 @@ func WithErrorOnReplace() Option {
 	})
 }
 
+func WithExtraHttpHeader(key, value string) Option {
+	return optionFunc(func(o *options) {
+		o.extraHttpHeaders[key] = value
+	})
+}
+
+func WithRewriteHostHeader(host string) Option {
+	return optionFunc(func(o *options) {
+		o.rewriteHostHeader = host
+	})
+}
+
 // mux abstracts away the behavior we expect from the http.ServeMux type in this package.
 type mux interface {
 	http.Handler
@@ -271,7 +285,19 @@ func NewRoutes(upstream *url.URL, label string, extractLabeler ExtractLabeler, o
 		opt.registerer = prometheus.NewRegistry()
 	}
 
-	proxy := httputil.NewSingleHostReverseProxy(upstream)
+	proxy := &httputil.ReverseProxy{
+		Rewrite: func(r *httputil.ProxyRequest) {
+			r.SetURL(upstream)
+			if opt.rewriteHostHeader == "" {
+				r.Out.Host = r.In.Host
+			} else {
+				r.Out.Host = opt.rewriteHostHeader
+			}
+			for header, val := range opt.extraHttpHeaders {
+				r.Out.Header.Set(header, val)
+			}
+		},
+	}
 
 	r := &routes{
 		upstream:       upstream,
diff --git a/main.go b/main.go
index 9c3520ff..c0d58a18 100644
--- a/main.go
+++ b/main.go
@@ -64,6 +64,8 @@ func main() {
 		enableLabelAPIs        bool
 		unsafePassthroughPaths string // Comma-delimited string.
 		errorOnReplace         bool
+		extraHttpHeaders       arrayFlags
+		rewriteHostHeader      string
 	)
 
 	flagset := flag.NewFlagSet(os.Args[0], flag.ExitOnError)
@@ -81,6 +83,8 @@ func main() {
 		"This option is checked after Prometheus APIs, you cannot override enforced API endpoints to be not enforced with this option. Use carefully as it can easily cause a data leak if the provided path is an important "+
 		"API (like /api/v1/configuration) which isn't enforced by prom-label-proxy. NOTE: \"all\" matching paths like \"/\" or \"\" and regex are not allowed.")
 	flagset.BoolVar(&errorOnReplace, "error-on-replace", false, "When specified, the proxy will return HTTP status code 400 if the query already contains a label matcher that differs from the one the proxy would inject.")
+	flagset.Var(&extraHttpHeaders, "extra-http-header", "HTTP header to add to the upstream query in the format 'header: value'. Can be repeated multiple times.")
+	flagset.StringVar(&rewriteHostHeader, "rewrite-host-header-to", "", "Rewrite host header to supplied value when sending the query to the upstream URL.")
 
 	//nolint: errcheck // Parse() will exit on error.
 	flagset.Parse(os.Args[1:])
@@ -126,6 +130,18 @@ func main() {
 		opts = append(opts, injectproxy.WithErrorOnReplace())
 	}
 
+	for _, headerArg := range extraHttpHeaders {
+		header, val, found := strings.Cut(headerArg, ":")
+		if !found || len(strings.TrimSpace(header)) == 0 || len(strings.TrimSpace(val)) == 0 {
+			log.Fatalf("extra-http-header %s is not in the format 'key:value'", headerArg)
+		}
+		opts = append(opts, injectproxy.WithExtraHttpHeader(header, val))
+	}
+
+	if len(rewriteHostHeader) > 0 {
+		opts = append(opts, injectproxy.WithRewriteHostHeader(rewriteHostHeader))
+	}
+
 	var extractLabeler injectproxy.ExtractLabeler
 	switch {
 	case len(labelValues) > 0: