diff --git a/superset-frontend/src/pages/Home/Home.test.tsx b/superset-frontend/src/pages/Home/Home.test.tsx
index 6be4dc186ed79..f470e9ea7380d 100644
--- a/superset-frontend/src/pages/Home/Home.test.tsx
+++ b/superset-frontend/src/pages/Home/Home.test.tsx
@@ -228,3 +228,28 @@ test('Should render a submenu extension component if one is supplied', async ()
 
   expect(screen.getByText('submenu extension')).toBeInTheDocument();
 });
+
+test('Should not make data fetch calls if `welcome.main.replacement` is defined', async () => {
+  const extensionsRegistry = getExtensionsRegistry();
+
+  // Clean up
+  extensionsRegistry.set('welcome.banner', () => null);
+
+  // Set up
+  extensionsRegistry.set('welcome.main.replacement', () => (
+    <>welcome.main.replacement extension component</>
+  ));
+
+  setupExtensions();
+
+  await renderWelcome();
+
+  expect(
+    screen.getByText('welcome.main.replacement extension component'),
+  ).toBeInTheDocument();
+
+  expect(fetchMock.calls(chartsEndpoint)).toHaveLength(0);
+  expect(fetchMock.calls(dashboardsEndpoint)).toHaveLength(0);
+  expect(fetchMock.calls(recentActivityEndpoint)).toHaveLength(0);
+  expect(fetchMock.calls(savedQueryEndpoint)).toHaveLength(0);
+});
diff --git a/superset-frontend/src/pages/Home/index.tsx b/superset-frontend/src/pages/Home/index.tsx
index 5661451a42df9..b92e84f486dc5 100644
--- a/superset-frontend/src/pages/Home/index.tsx
+++ b/superset-frontend/src/pages/Home/index.tsx
@@ -218,7 +218,7 @@ function Welcome({ user, addDangerToast }: WelcomeProps) {
   }, []);
 
   useEffect(() => {
-    if (!otherTabFilters) {
+    if (!otherTabFilters || WelcomeMainExtension) {
       return;
     }
     const activeTab = getItem(LocalStorageKeys.HomepageActivityFilter, null);