diff --git a/.github/workflows/unit-tests.yml b/.github/workflows/unit-tests.yml
index d908a68a8be4a..b501c2ea394bd 100644
--- a/.github/workflows/unit-tests.yml
+++ b/.github/workflows/unit-tests.yml
@@ -75,11 +75,6 @@ jobs:
             env_file: actions-311.yaml
             pandas_future_infer_string: "1"
             platform: ubuntu-24.04
-          - name: "Pypy"
-            env_file: actions-pypy-39.yaml
-            pattern: "not slow and not network and not single_cpu"
-            test_args: "--max-worker-restart 0"
-            platform: ubuntu-24.04
           - name: "Numpy Dev"
             env_file: actions-311-numpydev.yaml
             pattern: "not slow and not network and not single_cpu"
@@ -169,12 +164,9 @@ jobs:
       with:
         # xref https://github.com/cython/cython/issues/6870
         werror: ${{ matrix.name != 'Freethreading' }}
-      # TODO: Re-enable once Pypy has Pypy 3.10 on conda-forge
-      if: ${{ matrix.name != 'Pypy' }}
 
     - name: Test (not single_cpu)
       uses: ./.github/actions/run-tests
-      if: ${{ matrix.name != 'Pypy' }}
       env:
         # Set pattern to not single_cpu if not already set
         PATTERN: ${{ env.PATTERN == '' && 'not single_cpu' || matrix.pattern }}
diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
index 4de7aec4f551a..a38ec5ee359d9 100644
--- a/.github/workflows/wheels.yml
+++ b/.github/workflows/wheels.yml
@@ -101,7 +101,6 @@ jobs:
         - [macos-14, macosx_arm64]
         - [windows-2022, win_amd64]
         - [windows-11-arm, win_arm64]
-        # TODO: support PyPy?
         python: [["cp310", "3.10"], ["cp311", "3.11"], ["cp312", "3.12"], ["cp313", "3.13"], ["cp313t", "3.13"]]
         include:
         # Build Pyodide wheels and upload them to Anaconda.org
diff --git a/ci/deps/actions-pypy-39.yaml b/ci/deps/actions-pypy-39.yaml
deleted file mode 100644
index da1e2bc2f934f..0000000000000
--- a/ci/deps/actions-pypy-39.yaml
+++ /dev/null
@@ -1,26 +0,0 @@
-name: pandas-dev
-channels:
-  - conda-forge
-dependencies:
-  # TODO: Add the rest of the dependencies in here
-  # once the other plentiful failures/segfaults
-  # with base pandas has been dealt with
-  - python=3.9[build=*_pypy]
-
-  # build dependencies
-  - versioneer
-  - cython<4.0.0a0
-  - meson=1.2.1
-  - meson-python=0.13.1
-
-  # test dependencies
-  - pytest>=7.3.2
-  - pytest-cov
-  - pytest-xdist>=3.4.0
-  - hypothesis>=6.84.0
-
-  # required
-  - numpy
-  - python-dateutil
-  - pip:
-    - tzdata>=2023.3
diff --git a/scripts/validate_min_versions_in_sync.py b/scripts/validate_min_versions_in_sync.py
index 7908aaef3d890..a45791f6c05cd 100755
--- a/scripts/validate_min_versions_in_sync.py
+++ b/scripts/validate_min_versions_in_sync.py
@@ -37,7 +37,6 @@
 YAML_PATH = pathlib.Path("ci/deps")
 ENV_PATH = pathlib.Path("environment.yml")
 EXCLUDE_DEPS = {"tzdata", "pyqt", "pyqt5"}
-EXCLUSION_LIST = frozenset(["python=3.8[build=*_pypy]"])
 # pandas package is not available
 # in pre-commit environment
 sys.path.append("pandas/compat")
@@ -111,7 +110,6 @@ def get_yaml_map_from(
     for dependency in yaml_dic:
         if (
             isinstance(dependency, dict)
-            or dependency in EXCLUSION_LIST
             or dependency in yaml_map
         ):
             continue
@@ -124,11 +122,6 @@ def get_yaml_map_from(
             yaml_package, yaml_version2 = yaml_dependency.split(operator)
             yaml_version2 = operator + yaml_version2
             yaml_map[yaml_package] = [yaml_version1, yaml_version2]
-        elif "[build=*_pypy]" in dependency:
-            search_text = search_text.replace("[build=*_pypy]", "")
-            yaml_package, yaml_version = search_text.split(operator)
-            yaml_version = operator + yaml_version
-            yaml_map[yaml_package] = [yaml_version]
         elif operator is not None:
             yaml_package, yaml_version = search_text.split(operator)
             yaml_version = operator + yaml_version
@@ -164,8 +157,6 @@ def pin_min_versions_to_yaml_file(
 ) -> str:
     data = yaml_file_data
     for yaml_package, yaml_versions in yaml_map.items():
-        if yaml_package in EXCLUSION_LIST:
-            continue
         old_dep = yaml_package
         if yaml_versions is not None:
             old_dep = old_dep + ", ".join(yaml_versions)