diff --git a/.github/workflows/CI.yml b/.github/workflows/CI.yml
index d5a83548b..6fa2bbf1b 100644
--- a/.github/workflows/CI.yml
+++ b/.github/workflows/CI.yml
@@ -31,13 +31,6 @@ jobs:
         python-version: ["3.10", "3.11", "3.12"]
         rdkit: [true, false]
         openeye: [true, false]
-        exclude:
-          - rdkit: false
-            openeye: false
-          - openeye: true
-            python-version: "3.11"
-          - openeye: true
-            python-version: "3.12"
 
     env:
       OE_LICENSE: ${{ github.workspace }}/oe_license.txt