diff --git a/src/quic/session.cc b/src/quic/session.cc
index 0f5fb0d952584a..8466bed35f7823 100644
--- a/src/quic/session.cc
+++ b/src/quic/session.cc
@@ -2813,9 +2813,9 @@ bool Session::ReadPacket(const uint8_t* data,
       Debug(this, "Session successfully received %zu-byte packet", len);
       if (!is_destroyed()) [[likely]] {
         STAT_INCREMENT_N(Stats, bytes_received, len);
-        // Process deferred operations that couldn't run inside callback
-        // scopes (e.g., HTTP/3 GOAWAY handling that calls into JS).
-        application().PostReceive();
+        // Process deferred application operations after ALPN selection - not
+        // necessarily resolved yet as ClientHello can span multiple packets.
+        if (has_application()) application().PostReceive();
         // Surface a server session to JS once its ClientHello has been
         // processed (OnSelectAlpn fired: SNI + ALPN are known and reliable).
         // Held first-flight events - including 0-RTT request streams - replay
diff --git a/test/parallel/test-quic-multipacket-clienthello.mjs b/test/parallel/test-quic-multipacket-clienthello.mjs
new file mode 100644
index 00000000000000..2d701a899fc46d
--- /dev/null
+++ b/test/parallel/test-quic-multipacket-clienthello.mjs
@@ -0,0 +1,60 @@
+// Flags: --experimental-quic --experimental-stream-iter --no-warnings
+
+// A large post-quantum key share splits the ClientHello across QUIC Initial
+// packets. The server must accept the incomplete first packet before ALPN has
+// selected its application, then complete the handshake and process streams.
+
+import { hasQuic, skip, mustCall } from '../common/index.mjs';
+import assert from 'node:assert';
+import * as fixtures from '../common/fixtures.mjs';
+
+if (!hasQuic) {
+  skip('QUIC is not enabled');
+}
+
+const { createPrivateKey } = await import('node:crypto');
+const { listen, connect } = await import('node:quic');
+const { bytes } = await import('stream/iter');
+
+const key = createPrivateKey(fixtures.readKey('agent1-key.pem'));
+const cert = fixtures.readKey('agent1-cert.pem');
+const alpn = 'quic-multipacket-clienthello';
+const groups = 'X25519MLKEM768';
+const streamReceived = Promise.withResolvers();
+
+const endpoint = await listen(mustCall(async (session) => {
+  const info = await session.opened;
+  assert.strictEqual(session.alpnProtocol, alpn);
+  assert.strictEqual(info.cipherVersion, 'TLSv1.3');
+
+  session.onstream = mustCall(async (stream) => {
+    assert.strictEqual(
+      Buffer.from(await bytes(stream)).toString(),
+      'application event survived',
+    );
+    stream.writer.endSync();
+    await stream.closed;
+    streamReceived.resolve();
+  });
+}), {
+  host: '127.0.0.1',
+  port: 0,
+  alpn: [alpn],
+  groups,
+  sni: { '*': { keys: [key], certs: [cert] } },
+});
+
+const session = await connect(endpoint.address, {
+  alpn,
+  groups,
+  servername: 'localhost',
+  verifyPeer: 'manual',
+});
+
+await session.opened;
+const stream = await session.createBidirectionalStream({
+  body: 'application event survived',
+});
+await Promise.all([stream.closed, streamReceived.promise]);
+await session.close();
+await endpoint.close();