What we see in Hi-C: Introduction to chromatin biology and sequencing assays, Hi-C data browsing and feature extraction
Welcome to "What we see in Hi-C?" workshop!
This is a two-part intro to Hi-C data analysis:
- Part I covers qualitative Hi-C data analysis in interactive browsers (higlass, resgen)
- Part II shows how to use flexibility of Python programming for whole-genome visualization, compartments, domains and scaling analysis of Hi-C with Open2C tools.
Disclaimer: although we formally refer to whole-genome chromosome capture data as Hi-C, we will mostly work with Micro-C here.
To start, follow the instructions in What_we_see_in_Hi-C notebook.
Author: Aleksandra Galitsyna, based on the materials from Open2C and 4DN communities.
First version of the workshop has been presented at the conference "Genome Architecture and Function" in Boston, 2024.
- Workshop 2024 link: https://github.com/mirnylab/Hi-C_Workshop/releases/tag/v1.0
- Workshop 2024 recording: https://youtu.be/Z7fa5_xfifc
Next, the workshop waspresented at the conference "Physics Meets Genome" in Cargese, 2025.