From 7be4ec1885f44a3280e832a646a31ce8cb05db41 Mon Sep 17 00:00:00 2001 From: Michael McLaren Date: Sun, 20 Dec 2020 18:16:51 -0500 Subject: [PATCH] Build site --- docs/404.html | 5 +- docs/LICENSE-text.html | 5 +- docs/LICENSE.html | 5 +- docs/articles/index.html | 5 +- docs/articles/tutorial.html | 404 +++++++++--------- .../anchor-sections-1.0/anchor-sections.css | 4 + .../anchor-sections-1.0/anchor-sections.js | 33 ++ .../figure-html/unnamed-chunk-11-1.png | Bin 67831 -> 67680 bytes .../figure-html/unnamed-chunk-17-1.png | Bin 29783 -> 30108 bytes .../figure-html/unnamed-chunk-20-1.png | Bin 88015 -> 88089 bytes .../figure-html/unnamed-chunk-23-1.png | Bin 66719 -> 66573 bytes .../figure-html/unnamed-chunk-24-1.png | Bin 87458 -> 87269 bytes .../figure-html/unnamed-chunk-8-1.png | Bin 33214 -> 33331 bytes .../header-attrs-2.5/header-attrs.js | 12 + docs/authors.html | 5 +- docs/index.html | 11 +- docs/news/index.html | 201 +++++++++ docs/pkgdown.yml | 4 +- docs/reference/anorm.html | 5 +- docs/reference/as_matrix.html | 5 +- docs/reference/bootrep_center.html | 5 +- docs/reference/build_matrix.html | 5 +- docs/reference/calibrate.html | 5 +- docs/reference/center.html | 5 +- docs/reference/center_elts.html | 5 +- docs/reference/close_elts.html | 5 +- docs/reference/clr.html | 5 +- docs/reference/compute_ratios.html | 5 +- docs/reference/cooccurrence.html | 5 +- docs/reference/corner.html | 5 +- docs/reference/estimate_bias.html | 5 +- docs/reference/gm.html | 5 +- docs/reference/gm_abs.html | 5 +- docs/reference/gm_mean.html | 5 +- docs/reference/gm_range.html | 5 +- docs/reference/gm_sd.html | 5 +- docs/reference/import_phyloseq.html | 5 +- docs/reference/index.html | 5 +- docs/reference/log_center_proj.html | 5 +- docs/reference/log_center_rss.html | 5 +- docs/reference/logit.html | 5 +- docs/reference/mutate_by.html | 5 +- docs/reference/odds.html | 5 +- docs/reference/pairwise_ratios.html | 5 +- docs/reference/perturb.html | 10 +- docs/reference/proj_mat.html | 5 +- docs/reference/xydist.html | 5 +- 47 files changed, 605 insertions(+), 239 deletions(-) create mode 100644 docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.css create mode 100644 docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.js create mode 100644 docs/articles/tutorial_files/header-attrs-2.5/header-attrs.js create mode 100644 docs/news/index.html diff --git a/docs/404.html b/docs/404.html index 7afac8d..3a466d4 100644 --- a/docs/404.html +++ b/docs/404.html @@ -71,7 +71,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -97,6 +97,9 @@ Tutorial + +
  • + Changelog
    • + +
  • + Changelog
    • + +
  • + Changelog
    • + +
  • + Changelog
    • + +
  • + Changelog

    • Here I will use a pseudocount to make all the taxa abundances positive prior to calibration.

    -
    -ps.pseudo <- transform_sample_counts(ps, function(x) x + 1)
+
    +ps.pseudo <- transform_sample_counts(ps, function(x) x + 1)
 ps.pseudo.cal <- calibrate(ps.pseudo, bias) %>% print
 #> phyloseq-class experiment-level object
 #> otu_table()   OTU Table:         [ 9 taxa and 567 samples ]
 #> sample_data() Sample Data:       [ 567 samples by 16 sample variables ]
 #> tax_table()   Taxonomy Table:    [ 9 taxa by 7 taxonomic ranks ]
-#> refseq()      DNAStringSet:      [ 9 reference sequences ]
    
-
    To verify calibration that worked as expected, let’s compare the observed, calibrated, and actual taxon proportions in the 10 control samples. Again, I’ll start by adding the calibrated proportions to the data frame with observed and actual proportions,
    
-
    -ps.pseudo.cal.mock <- ps.pseudo.cal %>% 
+#> refseq()      DNAStringSet:      [ 9 reference sequences ]
    
+
    To verify that calibration worked as expected, let’s compare the observed, calibrated, and actual taxon proportions in the 10 control samples. Again, I’ll start by adding the calibrated proportions to the data frame with observed and actual proportions,
    
+
    +ps.pseudo.cal.mock <- ps.pseudo.cal %>% 
   subset_samples(Samp_type == "Mock")
 props.cal <- bind_rows(
   props, 
   psmelt(ps.pseudo.cal.mock) %>% add_column(Type = "Calibrated")
 ) %>%
-  select(Type, OTU, Sample, Abundance)
    
+  select(Type, OTU, Sample, Abundance)

    First, let’s look at bar plots comparing the observed, calibrated, and actual compositions,

    -
    -props.cal %>%
+
    +props.cal %>%
   mutate(
     across(Type, fct_rev),
     across(Sample, factor, levels = sample_names(mock_actual)),
@@ -420,11 +424,11 @@ 
    
   facet_wrap(~Sample, ncol = 5) +
   theme(
     axis.text.x = element_text(angle = 90, vjust = 0.5)
-  )
    
+  )

    We can see that the calibrated compositions are typically substantially closer to the actual proportions than the original observations. We can also plot the calibrated vs. actual (pseudo-log-transformed) proportions and compare to the earlier plot of observed vs. actual.

    -
    -props.cal %>%
+
    +props.cal %>%
   pivot_wider(names_from = Type, values_from = Abundance) %>%
   pivot_longer(c(Observed, Calibrated), 
     names_to = "Type", values_to = "Proportion") %>%
@@ -434,15 +438,15 @@ 
    
   geom_quasirandom() +
   facet_wrap(~Type) +
   axes +
-  scale_color_brewer(type = "qual", palette = 3)
    
+  scale_color_brewer(type = "qual", palette = 3)

    -

    This plot has essentially same information as the earlier plot examining the model fit, but seen from a slightly different angle. We can see that calibration in this dataset clearly reduces the relative error in proportions across the full range of tested true proportions, but leads to estimates that are systematically too low at low proportions by a small factor.

    +

    This plot has essentially same information as the earlier plot examining the model fit, but seen from a different angle. We can see that calibration in this dataset clearly reduces the relative error in proportions across the tested range of actual proportions, but leads to estimates that are systematically too low at low proportions.

    Session info

    -
    -sessioninfo::session_info()
+
    +sessioninfo::session_info()
 #> ─ Session info ───────────────────────────────────────────────────────────────
 #>  setting  value                       
 #>  version  R version 4.0.3 (2020-10-10)
@@ -453,119 +457,123 @@ 
    
 #>  collate  en_US.UTF-8                 
 #>  ctype    en_US.UTF-8                 
 #>  tz       America/New_York            
-#>  date     2020-10-21                  
+#>  date     2020-12-20                  
 #> 
 #> ─ Packages ───────────────────────────────────────────────────────────────────
-#>  package      * version    date       lib source        
-#>  ade4           1.7-15     2020-02-13 [2] CRAN (R 4.0.0)
-#>  ape            5.4-1      2020-08-13 [2] CRAN (R 4.0.2)
-#>  assertthat     0.2.1      2019-03-21 [2] CRAN (R 4.0.0)
-#>  backports      1.1.10     2020-09-15 [2] CRAN (R 4.0.2)
-#>  beeswarm       0.2.3      2016-04-25 [2] CRAN (R 4.0.0)
-#>  Biobase        2.48.0     2020-04-27 [2] Bioconductor  
-#>  BiocGenerics   0.34.0     2020-04-27 [2] Bioconductor  
-#>  biomformat     1.16.0     2020-04-27 [2] Bioconductor  
-#>  Biostrings     2.56.0     2020-04-27 [2] Bioconductor  
-#>  blob           1.2.1      2020-01-20 [2] CRAN (R 4.0.0)
-#>  broom          0.7.1      2020-10-02 [2] CRAN (R 4.0.2)
-#>  cellranger     1.1.0      2016-07-27 [2] CRAN (R 4.0.0)
-#>  cli            2.0.2      2020-02-28 [2] CRAN (R 4.0.2)
-#>  cluster        2.1.0      2019-06-19 [3] CRAN (R 4.0.3)
-#>  codetools      0.2-16     2018-12-24 [3] CRAN (R 4.0.3)
-#>  colorspace     1.4-1      2019-03-18 [2] CRAN (R 4.0.0)
-#>  cowplot      * 1.1.0      2020-09-08 [2] CRAN (R 4.0.2)
-#>  crayon         1.3.4      2017-09-16 [2] CRAN (R 4.0.0)
-#>  data.table     1.13.0     2020-07-24 [2] CRAN (R 4.0.2)
-#>  DBI            1.1.0      2019-12-15 [2] CRAN (R 4.0.0)
-#>  dbplyr         1.4.4      2020-05-27 [2] CRAN (R 4.0.0)
-#>  desc           1.2.0      2018-05-01 [2] CRAN (R 4.0.0)
-#>  digest         0.6.25     2020-02-23 [2] CRAN (R 4.0.0)
-#>  dplyr        * 1.0.2      2020-08-18 [2] CRAN (R 4.0.2)
-#>  ellipsis       0.3.1      2020-05-15 [2] CRAN (R 4.0.0)
-#>  evaluate       0.14       2019-05-28 [2] CRAN (R 4.0.0)
-#>  fansi          0.4.1      2020-01-08 [2] CRAN (R 4.0.0)
-#>  farver         2.0.3      2020-01-16 [2] CRAN (R 4.0.0)
-#>  forcats      * 0.5.0      2020-03-01 [2] CRAN (R 4.0.0)
-#>  foreach        1.5.0      2020-03-30 [2] CRAN (R 4.0.2)
-#>  fs             1.5.0      2020-07-31 [2] CRAN (R 4.0.2)
-#>  generics       0.0.2      2018-11-29 [2] CRAN (R 4.0.0)
-#>  ggbeeswarm   * 0.6.0      2017-08-07 [2] CRAN (R 4.0.0)
-#>  ggplot2      * 3.3.2      2020-06-19 [2] CRAN (R 4.0.1)
-#>  glue           1.4.2      2020-08-27 [2] CRAN (R 4.0.2)
-#>  gtable         0.3.0      2019-03-25 [2] CRAN (R 4.0.0)
-#>  haven          2.3.1      2020-06-01 [2] CRAN (R 4.0.1)
-#>  here           0.1        2017-05-28 [2] CRAN (R 4.0.0)
-#>  hms            0.5.3      2020-01-08 [2] CRAN (R 4.0.0)
-#>  htmltools      0.5.0      2020-06-16 [2] CRAN (R 4.0.1)
-#>  httr           1.4.2      2020-07-20 [2] CRAN (R 4.0.2)
-#>  igraph         1.2.5      2020-03-19 [2] CRAN (R 4.0.0)
-#>  IRanges        2.22.2     2020-05-21 [2] Bioconductor  
-#>  iterators      1.0.12     2019-07-26 [2] CRAN (R 4.0.0)
-#>  jsonlite       1.7.1      2020-09-07 [2] CRAN (R 4.0.2)
-#>  knitr          1.30       2020-09-22 [2] CRAN (R 4.0.2)
-#>  labeling       0.3        2014-08-23 [2] CRAN (R 4.0.0)
-#>  lattice        0.20-41    2020-04-02 [3] CRAN (R 4.0.3)
-#>  lifecycle      0.2.0      2020-03-06 [2] CRAN (R 4.0.0)
-#>  lubridate      1.7.9      2020-06-08 [2] CRAN (R 4.0.1)
-#>  magrittr       1.5        2014-11-22 [2] CRAN (R 4.0.0)
-#>  MASS           7.3-53     2020-09-09 [3] CRAN (R 4.0.3)
-#>  Matrix         1.2-18     2019-11-27 [3] CRAN (R 4.0.3)
-#>  memoise        1.1.0      2017-04-21 [2] CRAN (R 4.0.0)
-#>  metacal      * 0.1.0.9011 2020-10-21 [1] local         
-#>  mgcv           1.8-33     2020-08-27 [3] CRAN (R 4.0.3)
-#>  modelr         0.1.8      2020-05-19 [2] CRAN (R 4.0.0)
-#>  multtest       2.44.0     2020-04-27 [2] Bioconductor  
-#>  munsell        0.5.0      2018-06-12 [2] CRAN (R 4.0.0)
-#>  nlme           3.1-149    2020-08-23 [3] CRAN (R 4.0.3)
-#>  permute        0.9-5      2019-03-12 [2] CRAN (R 4.0.0)
-#>  phyloseq     * 1.32.0     2020-04-27 [2] Bioconductor  
-#>  pillar         1.4.6      2020-07-10 [2] CRAN (R 4.0.2)
-#>  pkgconfig      2.0.3      2019-09-22 [2] CRAN (R 4.0.0)
-#>  pkgdown        1.6.1      2020-09-12 [2] CRAN (R 4.0.2)
-#>  plyr           1.8.6      2020-03-03 [2] CRAN (R 4.0.0)
-#>  purrr        * 0.3.4      2020-04-17 [2] CRAN (R 4.0.0)
-#>  R6             2.4.1      2019-11-12 [2] CRAN (R 4.0.0)
-#>  ragg           0.3.1      2020-07-03 [2] CRAN (R 4.0.2)
-#>  RColorBrewer   1.1-2      2014-12-07 [2] CRAN (R 4.0.0)
-#>  Rcpp           1.0.5      2020-07-06 [2] CRAN (R 4.0.2)
-#>  readr        * 1.3.1      2018-12-21 [2] CRAN (R 4.0.0)
-#>  readxl         1.3.1      2019-03-13 [2] CRAN (R 4.0.0)
-#>  reprex         0.3.0      2019-05-16 [2] CRAN (R 4.0.1)
-#>  reshape2       1.4.4      2020-04-09 [2] CRAN (R 4.0.0)
-#>  rhdf5          2.32.2     2020-07-03 [2] Bioconductor  
-#>  Rhdf5lib       1.10.1     2020-07-09 [2] Bioconductor  
-#>  rlang          0.4.7      2020-07-09 [2] CRAN (R 4.0.2)
-#>  rmarkdown      2.4        2020-09-30 [2] CRAN (R 4.0.2)
-#>  rprojroot      1.3-2      2018-01-03 [2] CRAN (R 4.0.0)
-#>  rstudioapi     0.11       2020-02-07 [2] CRAN (R 4.0.0)
-#>  rvest          0.3.6      2020-07-25 [2] CRAN (R 4.0.2)
-#>  S4Vectors      0.26.1     2020-05-16 [2] Bioconductor  
-#>  scales         1.1.1      2020-05-11 [2] CRAN (R 4.0.0)
-#>  sessioninfo    1.1.1      2018-11-05 [2] CRAN (R 4.0.0)
-#>  stringi        1.5.3      2020-09-09 [2] CRAN (R 4.0.2)
-#>  stringr      * 1.4.0      2019-02-10 [2] CRAN (R 4.0.0)
-#>  survival       3.2-7      2020-09-28 [3] CRAN (R 4.0.3)
-#>  systemfonts    0.3.2      2020-09-29 [2] CRAN (R 4.0.2)
-#>  tibble       * 3.0.3      2020-07-10 [2] CRAN (R 4.0.2)
-#>  tidyr        * 1.1.2      2020-08-27 [2] CRAN (R 4.0.2)
-#>  tidyselect     1.1.0      2020-05-11 [2] CRAN (R 4.0.0)
-#>  tidyverse    * 1.3.0      2019-11-21 [2] CRAN (R 4.0.0)
-#>  useful         1.2.6      2018-10-08 [2] CRAN (R 4.0.0)
-#>  utf8           1.1.4      2018-05-24 [2] CRAN (R 4.0.0)
-#>  vctrs          0.3.4      2020-08-29 [2] CRAN (R 4.0.2)
-#>  vegan          2.5-6      2019-09-01 [2] CRAN (R 4.0.0)
-#>  vipor          0.4.5      2017-03-22 [2] CRAN (R 4.0.0)
-#>  viridisLite    0.3.0      2018-02-01 [2] CRAN (R 4.0.0)
-#>  withr          2.3.0      2020-09-22 [2] CRAN (R 4.0.2)
-#>  xfun           0.18       2020-09-29 [2] CRAN (R 4.0.2)
-#>  xml2           1.3.2      2020-04-23 [2] CRAN (R 4.0.0)
-#>  XVector        0.28.0     2020-04-27 [2] Bioconductor  
-#>  yaml           2.2.1      2020-02-01 [2] CRAN (R 4.0.0)
-#>  zlibbioc       1.34.0     2020-04-27 [2] Bioconductor  
+#>  package      * version date       lib source        
+#>  ade4           1.7-16  2020-10-28 [2] CRAN (R 4.0.3)
+#>  ape            5.4-1   2020-08-13 [2] CRAN (R 4.0.2)
+#>  assertthat     0.2.1   2019-03-21 [2] CRAN (R 4.0.0)
+#>  backports      1.2.0   2020-11-02 [2] CRAN (R 4.0.3)
+#>  beeswarm       0.2.3   2016-04-25 [2] CRAN (R 4.0.0)
+#>  Biobase        2.50.0  2020-10-27 [2] Bioconductor  
+#>  BiocGenerics   0.36.0  2020-10-27 [2] Bioconductor  
+#>  biomformat     1.18.0  2020-10-27 [2] Bioconductor  
+#>  Biostrings     2.58.0  2020-10-27 [2] Bioconductor  
+#>  broom          0.7.2   2020-10-20 [2] CRAN (R 4.0.3)
+#>  cellranger     1.1.0   2016-07-27 [2] CRAN (R 4.0.0)
+#>  cli            2.2.0   2020-11-20 [2] CRAN (R 4.0.3)
+#>  cluster        2.1.0   2019-06-19 [3] CRAN (R 4.0.3)
+#>  codetools      0.2-16  2018-12-24 [3] CRAN (R 4.0.3)
+#>  colorspace     2.0-0   2020-11-11 [2] CRAN (R 4.0.3)
+#>  cowplot      * 1.1.0   2020-09-08 [2] CRAN (R 4.0.2)
+#>  crayon         1.3.4   2017-09-16 [2] CRAN (R 4.0.0)
+#>  data.table     1.13.2  2020-10-19 [2] CRAN (R 4.0.3)
+#>  DBI            1.1.0   2019-12-15 [2] CRAN (R 4.0.0)
+#>  dbplyr         2.0.0   2020-11-03 [2] CRAN (R 4.0.3)
+#>  desc           1.2.0   2018-05-01 [2] CRAN (R 4.0.0)
+#>  digest         0.6.27  2020-10-24 [2] CRAN (R 4.0.3)
+#>  dplyr        * 1.0.2   2020-08-18 [2] CRAN (R 4.0.2)
+#>  ellipsis       0.3.1   2020-05-15 [2] CRAN (R 4.0.0)
+#>  evaluate       0.14    2019-05-28 [2] CRAN (R 4.0.0)
+#>  fansi          0.4.1   2020-01-08 [2] CRAN (R 4.0.0)
+#>  farver         2.0.3   2020-01-16 [2] CRAN (R 4.0.0)
+#>  forcats      * 0.5.0   2020-03-01 [2] CRAN (R 4.0.0)
+#>  foreach        1.5.1   2020-10-15 [2] CRAN (R 4.0.3)
+#>  fs             1.5.0   2020-07-31 [2] CRAN (R 4.0.2)
+#>  generics       0.1.0   2020-10-31 [2] CRAN (R 4.0.3)
+#>  ggbeeswarm   * 0.6.0   2017-08-07 [2] CRAN (R 4.0.0)
+#>  ggplot2      * 3.3.2   2020-06-19 [2] CRAN (R 4.0.1)
+#>  glue           1.4.2   2020-08-27 [2] CRAN (R 4.0.2)
+#>  gtable         0.3.0   2019-03-25 [2] CRAN (R 4.0.0)
+#>  haven          2.3.1   2020-06-01 [2] CRAN (R 4.0.1)
+#>  here           1.0.0   2020-11-15 [2] CRAN (R 4.0.3)
+#>  hms            0.5.3   2020-01-08 [2] CRAN (R 4.0.0)
+#>  htmltools      0.5.0   2020-06-16 [2] CRAN (R 4.0.1)
+#>  httr           1.4.2   2020-07-20 [2] CRAN (R 4.0.2)
+#>  igraph         1.2.6   2020-10-06 [2] CRAN (R 4.0.3)
+#>  IRanges        2.24.0  2020-10-27 [2] Bioconductor  
+#>  iterators      1.0.13  2020-10-15 [2] CRAN (R 4.0.3)
+#>  jsonlite       1.7.1   2020-09-07 [2] CRAN (R 4.0.2)
+#>  knitr          1.30    2020-09-22 [2] CRAN (R 4.0.2)
+#>  labeling       0.4.2   2020-10-20 [2] CRAN (R 4.0.3)
+#>  lattice        0.20-41 2020-04-02 [3] CRAN (R 4.0.3)
+#>  lifecycle      0.2.0   2020-03-06 [2] CRAN (R 4.0.0)
+#>  lubridate      1.7.9.2 2020-11-13 [2] CRAN (R 4.0.3)
+#>  magrittr       2.0.1   2020-11-17 [2] CRAN (R 4.0.3)
+#>  MASS           7.3-53  2020-09-09 [3] CRAN (R 4.0.3)
+#>  Matrix         1.2-18  2019-11-27 [3] CRAN (R 4.0.3)
+#>  memoise        1.1.0   2017-04-21 [2] CRAN (R 4.0.0)
+#>  metacal      * 0.2.0   2020-12-20 [1] local         
+#>  mgcv           1.8-33  2020-08-27 [3] CRAN (R 4.0.3)
+#>  modelr         0.1.8   2020-05-19 [2] CRAN (R 4.0.0)
+#>  multtest       2.46.0  2020-10-27 [2] Bioconductor  
+#>  munsell        0.5.0   2018-06-12 [2] CRAN (R 4.0.0)
+#>  nlme           3.1-149 2020-08-23 [3] CRAN (R 4.0.3)
+#>  permute        0.9-5   2019-03-12 [2] CRAN (R 4.0.0)
+#>  phyloseq     * 1.34.0  2020-10-27 [2] Bioconductor  
+#>  pillar         1.4.7   2020-11-20 [2] CRAN (R 4.0.3)
+#>  pkgconfig      2.0.3   2019-09-22 [2] CRAN (R 4.0.0)
+#>  pkgdown        1.6.1   2020-09-12 [2] CRAN (R 4.0.2)
+#>  plyr           1.8.6   2020-03-03 [2] CRAN (R 4.0.0)
+#>  prettyunits    1.1.1   2020-01-24 [2] CRAN (R 4.0.0)
+#>  progress       1.2.2   2019-05-16 [2] CRAN (R 4.0.2)
+#>  ps             1.4.0   2020-10-07 [2] CRAN (R 4.0.3)
+#>  purrr        * 0.3.4   2020-04-17 [2] CRAN (R 4.0.0)
+#>  R6             2.5.0   2020-10-28 [2] CRAN (R 4.0.3)
+#>  ragg           0.4.0   2020-10-05 [2] CRAN (R 4.0.3)
+#>  RColorBrewer   1.1-2   2014-12-07 [2] CRAN (R 4.0.0)
+#>  Rcpp           1.0.5   2020-07-06 [2] CRAN (R 4.0.2)
+#>  readr        * 1.4.0   2020-10-05 [2] CRAN (R 4.0.3)
+#>  readxl         1.3.1   2019-03-13 [2] CRAN (R 4.0.0)
+#>  reprex         0.3.0   2019-05-16 [2] CRAN (R 4.0.1)
+#>  reshape2       1.4.4   2020-04-09 [2] CRAN (R 4.0.0)
+#>  rhdf5          2.34.0  2020-10-27 [2] Bioconductor  
+#>  rhdf5filters   1.2.0   2020-10-27 [2] Bioconductor  
+#>  Rhdf5lib       1.12.0  2020-10-27 [2] Bioconductor  
+#>  rlang          0.4.8   2020-10-08 [2] CRAN (R 4.0.3)
+#>  rmarkdown      2.5     2020-10-21 [2] CRAN (R 4.0.3)
+#>  rprojroot      2.0.2   2020-11-15 [2] CRAN (R 4.0.3)
+#>  rstudioapi     0.13    2020-11-12 [2] CRAN (R 4.0.3)
+#>  rvest          0.3.6   2020-07-25 [2] CRAN (R 4.0.2)
+#>  S4Vectors      0.28.0  2020-10-27 [2] Bioconductor  
+#>  scales         1.1.1   2020-05-11 [2] CRAN (R 4.0.0)
+#>  sessioninfo    1.1.1   2018-11-05 [2] CRAN (R 4.0.0)
+#>  stringi        1.5.3   2020-09-09 [2] CRAN (R 4.0.2)
+#>  stringr      * 1.4.0   2019-02-10 [2] CRAN (R 4.0.0)
+#>  survival       3.2-7   2020-09-28 [3] CRAN (R 4.0.3)
+#>  systemfonts    0.3.2   2020-09-29 [2] CRAN (R 4.0.2)
+#>  textshaping    0.2.1   2020-11-13 [2] CRAN (R 4.0.3)
+#>  tibble       * 3.0.4   2020-10-12 [2] CRAN (R 4.0.3)
+#>  tidyr        * 1.1.2   2020-08-27 [2] CRAN (R 4.0.2)
+#>  tidyselect     1.1.0   2020-05-11 [2] CRAN (R 4.0.0)
+#>  tidyverse    * 1.3.0   2019-11-21 [2] CRAN (R 4.0.0)
+#>  useful         1.2.6   2018-10-08 [2] CRAN (R 4.0.0)
+#>  utf8           1.1.4   2018-05-24 [2] CRAN (R 4.0.0)
+#>  vctrs          0.3.5   2020-11-17 [2] CRAN (R 4.0.3)
+#>  vegan          2.5-6   2019-09-01 [2] CRAN (R 4.0.0)
+#>  vipor          0.4.5   2017-03-22 [2] CRAN (R 4.0.0)
+#>  viridisLite    0.3.0   2018-02-01 [2] CRAN (R 4.0.0)
+#>  withr          2.3.0   2020-09-22 [2] CRAN (R 4.0.2)
+#>  xfun           0.19    2020-10-30 [2] CRAN (R 4.0.3)
+#>  xml2           1.3.2   2020-04-23 [2] CRAN (R 4.0.0)
+#>  XVector        0.30.0  2020-10-27 [2] Bioconductor  
+#>  yaml           2.2.1   2020-02-01 [2] CRAN (R 4.0.0)
+#>  zlibbioc       1.36.0  2020-10-27 [2] Bioconductor  
 #> 
-#> [1] /tmp/RtmppncHeN/temp_libpath18eca245f54b6
+#> [1] /tmp/Rtmp4AlMtO/temp_libpathfe674631225b
 #> [2] /home/michael/R/x86_64-pc-linux-gnu-library/4.0
-#> [3] /usr/lib/R/library
    
+#> [3] /usr/lib/R/library
    diff --git a/docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.css b/docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.css new file mode 100644 index 0000000..07aee5f --- /dev/null +++ b/docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.css @@ -0,0 +1,4 @@ +/* Styles for section anchors */ +a.anchor-section {margin-left: 10px; visibility: hidden; color: inherit;} +a.anchor-section::before {content: '#';} +.hasAnchor:hover a.anchor-section {visibility: visible;} diff --git a/docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.js b/docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.js new file mode 100644 index 0000000..570f99a --- /dev/null +++ b/docs/articles/tutorial_files/anchor-sections-1.0/anchor-sections.js @@ -0,0 +1,33 @@ +// Anchor sections v1.0 written by Atsushi Yasumoto on Oct 3rd, 2020. +document.addEventListener('DOMContentLoaded', function() { + // Do nothing if AnchorJS is used + if (typeof window.anchors === 'object' && anchors.hasOwnProperty('hasAnchorJSLink')) { + return; + } + + const h = document.querySelectorAll('h1, h2, h3, h4, h5, h6'); + + // Do nothing if sections are already anchored + if (Array.from(h).some(x => x.classList.contains('hasAnchor'))) { + return null; + } + + // Use section id when pandoc runs with --section-divs + const section_id = function(x) { + return ((x.classList.contains('section') || (x.tagName === 'SECTION')) + ? x.id : ''); + }; + + // Add anchors + h.forEach(function(x) { + const id = x.id || section_id(x.parentElement); + if (id === '') { + return null; + } + let anchor = document.createElement('a'); + anchor.href = '#' + id; + anchor.classList = ['anchor-section']; + x.classList.add('hasAnchor'); + x.appendChild(anchor); + }); +}); diff --git a/docs/articles/tutorial_files/figure-html/unnamed-chunk-11-1.png b/docs/articles/tutorial_files/figure-html/unnamed-chunk-11-1.png index 2fd0121feb834fe2dfadb38e8c71afbf4b151181..e9f108b2a44179172f06a39bf5e2ef91494b95ee 100644 GIT binary patch literal 67680 zcmdSAg;$i{_XbKME!`j?N|!J+Dh&ckcXxL;(j}lsgGz|>hZ=fl>5^`c?v8<(`wo78 zYu!KL-ghmS#c0mPkm?kQAifX!v9wEP4CTOilHj z9_M_qXf$)kv}_!UW5uH2nL>Z^QRNA~YYIps%L?}+)!U~Zmpd3j6hc0kK$wxGLYPU^ z!%(|D-t{T>Qp9(F^(RIG;owr6+GW1d^7)6rTx&Wj@6jO|tp0gn|KrAIjQ?MKo*#oC zqSc3@G9xn5j}LbKuUV{U`HoA>`h-JocB}shu0~;0P5hMb-;;c=hAjWDxpcu$2@>=F zHQLfZBKlt&R(Cd}nCO4cXJOKi|23B$$i{yCe~V$Mg8uCPy5uWH`Sic$@)_#?zv#XK zu~NYEnM$<$8=KwN17{O$G3x5H2Btx6aVz|c+W%%75li6l@!yn@uWtDp&L5oVUPYEK z5t|^jThE{mPmbLCUjC-e<8q2bEK9~D2@kL&$rPf8@f~f)s^L1P#Y=I2e0zfzRj4J) zPBLQt4t2a%cYrD-yA$pnj1(MR@5VB2Gp3~d8-us4P8%sO6+_4FyALtW*AK-46cm_Z zNC9YNXlclmDD9}SsGdEF6`j7XJxx;2s;M1&q9@mlsL6dCD@nE~h@x?v_C25Fy-^qu z_=&pBrrEJlY__cb;!YxJuJgYAchBgT&rkmCB@(pzhKnLmp4{5xXW-qCGIp~1i&}w- z-~7~I+8e?u;W5%3c`V&uULo_@4(krz1?5Dr0-luMXdjXkN*yWz;eGA?jfgZkUI6V%bz~J>g9;_zW+BDu z=k`KTYx*ZxOm(DjaS|V%m4%cNtY-Js-DHpjBnG0-kQj#&jOK?5|1D+2n9};fhPvFF zZH+4G8YwaUa1uJ#QxAwW+;c$pMGH7tn*G#7*EegpNyaf* zTr7-*)_9JCS^kh^hD2eZs$kyyutxcq_mAg^`5E7O(Sn%0HzZxbWEo`{-9K-eUySdp z$UVM;Otg<^^2O2Ve`3bY;)?^O-jns+_u7z2h;zts%AEfqzpZ}nO)TVG6T$#l35kHX ztqQMhzgA9h_k{#O@Xy0iz0`Gz^%?X{@DjwG&-8 zU*H{iUs;SIzr{Nda%|r)M%L3*la@Z);+ps4Juv!fAT3>RzK~bn&Q7+IRlFa7 z3DO*joZVW-eq(yi=(4C;y^Vo_qm~`a%k%6=?6P{FMU+JmJWd>QHbUaO6s>NJwi zo?iPLG+u6u2n!97qn4rG$6ZKzlL;l9L>MR4!_0R_L{VongfpbuEBh}{tT5KMKQ#w) zhYLGr{&24!csxr9kM=Uzp@shXrq~zUi?oVoP|X@23fTt}vS-XAftvD-W78$T&yV$; z6Zb=P3%G)OAm?B+6&8%1iZ4!RVy zi`AhIr8VH?A_)0MIBo6|u?Xs^R7Fl6T2L5|AqPYS5@jLTJB zg#s)%@uE#h1UNZ-dkyw5E-y})jQyPuu-hs2^b;`RosB2n?xb4#Kf^4+QxWyuq{e#A z7QbA6;0Aqcp0gePfwhydwb-G0a$I<5--z)Om9cvNqTr!;iOhRa7d?Q?UknS>^o`By z-HeV($2h;U#i!9g@CTIgM#pyx*L7sGU#^(=Id-)TutiaRBTcT4Joqo-IdD1-%3q_k zjm|R_true`Zhvw>d*1+YPhjR^^Z~PKkb#J*R*(xIA^zP`6L6VM*J_s4X{3FS8-CLK}NOpCp(`0~K*&9ePzw&ALl<20Rz>LKb`KBQgH!M-FPG zF|m)tB+6L1>nUbIwDQGyyJN~M@%nnjvxndHR0by)8lZLi{^zDm;%42+6f z&CJ=Gu)zr1b@4^{f>mBqtw?{#r@;Xjw_;D%7X@5}4Ko-8-yy$5DZ}rk&1U8@;-24b zQ~A9y5%cM8n{9#95c#Lh3|FKEdcH~Mix1UII?v`gP6Ala^XXixzZOJ0Y9?eUPWcU` zVwwH2k;LA1W*DKC{SW0+$Ado6z1|tGc>PoyIQgson(SsB%z$z+`WLMYyB21H`B{1@ z;B=7yBVE7<%q21n0J=q_%kM47aYspU}4WSb3 z*L05R-!p9_8M&uOs^4M1jw%2LvB~w(&Tt-GuDMoj+ikW;qvtoF#RD+$YN@?G5*|0<45Uv0HmTYwxt$GS# z36`zQ;0Rx&zrm^)JE3y&ER$BZ4^u1GBe}q@xRw`jM!(Wty~8g&H!_i&Bl+T^m%Q8Qn;frz#jL z<6#Ib0rx;M3HpG&k>{F(*(bgXs)CDDy{xHyTZ*3h&2fH9&BWbcV^{5j#lCXdQ;(M@ zdHtUU88F6SdU73eyd!3>KG zfbTG(nG()0P^&OBNZ{V1=Ul}gX!zC@GcKH?&^D~E1ed`c=o6~66_SWv^NEGD{~ zg(hmdvg^U>Y&Fx_XZ=!VsovYr2WJtNceB^4d6Ds`pgXpgS%j}U2o>p^s8qZce_565 ze}#~7w4r+rGh(tTpNAxwLowIxhA%K9yL0^$PuhuNaPbdD`&WfqFJ;s5M#Kx_Jr^ zHp3UU+fV$d%krnk`!$rlJOrRk{KZ&HZ%fw-gJ`7EGapz5^Kp;*kp0(Rt0ccx#suek ziy!`cPfS-@7+ucCP2_hyJrxg&Q^|sx9Ok}WRxYeuN%(F* z@Gjym0+w_ER*R)NU;M%${XnQ+FM#32cx|DH`s@me5KFQ{k>r<@8>{k?ZdG61Pd%P_ zI0wh6J-%+NZKLX34Qg#(ta=z?R0}KV^}A9H>uGwUvQ-2#KXDWHNw0<4KHVQfVAuQu zFZq?h!8I^K|AV#6-s7~3==E8#BiGs8%8CAeA(3U5;42@mhbGJpBaA;(K2OYpV(PT7 zg!~pV45OwhJ>Lym1@5@7Eo(TA1(vg-lHs2)i8<$qs19~*%fZ2YFG-6=RH7Ojg z&>Q{EB3+wBFC;v)9W6IY1^VT8EGPI(o4?}c3)0t*ffp+^Y*}ff%7vMy?|kTL`FEC_ zoa~~9rNtl4_Od(gmBSfv$8C2g%nW1~H7$@8eJv6B75a{%{W zZ2U#q7O#a}leSr+v6j<6?iPQDqmFscRq=#ST^U+5-;lgSlC*7W&vrQ8wynf#LwPfC z&UYvW<>)Nm`dV(iL6=9mp3b&<1=%QeVV^>8m4?z8mt>A?za_aLJSz=JN=K<#nt0d$l&^aCmQWF9|?h&VG_NO|~{COg~tR7A%Wlsdw3p`kw9n z1aSR_yhNe?{YinLvlGc-_4&KGh*N z?y}e5rjz*GQ_riSCTt_O7eA2vzUkxxn@zEX_DNy{Dct4l+L^qK21^I5qRo?A!!c-x z*LA|PRHmDh6=~__)4*GQ-hj4u7ALTNJ_gjArn)nR)fc?!#lt^ioS);I>$S`dR|~(i zV>}IfnzHLmPfhK`_O@^ybH?UUV6paF2Y53=-xs_rwt{MeSrIP^>t@~#WUN|2pV9F2 zS#0!QEixEFy+WIij zs7XVF=1N(=OfIR3+$sz=NjRj=->X(HteL@qc1leS+9}<#3$|Pz9p#BqdxZ&pIy2^F z;Gnd5s}sPbV^DqcVg3#W4>@;e{8lDKH<8_`O=;m_Z?2m2OK_^6M*_h?L>B(Eh@&Uw z{B_H~R}2$YM|k2=77I$6wwR#rwMj zs4fp#1;aFWr<o$j9i3@i6pn%kN@@&_gm<>$Lv3bJk zVFH`0>IQj*q`-IG37rF*qqh7m&zvk&zhf-*FLuu3waM_EGE_0Fef=Uy4dUZjVzXd( zWr|WE@Lg^QaqJ(ysHb*O@6ILTyiO-PtH z&y+{G4al7tDGi?fPyr*ecT(^^viV~HWpxy;fn-4xz$F+9Yg*~I{7wU7R0gIyIExyI zG2pOHKgb(qr~B+3D(zLLC!-yK6YUt@HPlRQ6gv0bVTjIu2~4=dLTr{PsNfW3Z z!8(1WePl5T%F;i8Mru{#R|MyWp^~F+KLs4jIN9-rPH??52tlRSp+H*=ntyE%(otVj zARom$B1R=uEe!!W`b;Tm?ogNGCF^WoHyaK#juxUq1{gmzmV=s&DE(1rU3>hR36mIT zt#qemD`-@jOMs~o{%iIYA%y&?4H~c@@|4jM-o5>8r$xGhFP{+15u+Gbu#8*lXBFo$U>%NBH1B=|+?kpQ2 zT=eIckJA&B4|ohg-6fh;g-DCAck@; zEF)jzd{}MuSG*MG3lNb2{rw}3M1;+&mcOI-nKV-95MG~&<_a*C$}OF}<8^zS>4Zsa zPDnJ#q9LTZ`awKoS7t~?+HFWeuwGwjblx!Gayn);xHDSciYlDb%LpM6Fe@EzWWjn{ z1sjAIKrH@V^8gLNa&E%_z!-0B7oI;CTJEgZnMRrvUuo_*aNj8H8Bt{}V^uFIbN}-} zj#Hr5hU62_$Y-NqZi-VG&8hVilC#3^ohu2=Vm~Vss4;kLF1Hm#+|G@lxwP!zzAmfWrNK z^*KVs5mki2VWqxW*}m#_(`o`o3y_mC(kCZAAqzHB6(AL009vu)>>)JC@<*ZNFb{#< zWRLFbf{Oi5J|=2C?BuVXqh$8WXWTuN534C6&3EwwY|3vZA*0mRfA^@cVkM1bevEIp zc?JRflo&i}q-EDlk@fGfCsXXrTLP4G%&=ubY%tagb zlUz21Q|mll^WK)6!$t%yMr?ZWe}pmVNm7wq7D@Jiou_1_PPn{$NU+XByL;}pq~kAZ z4o4=paK|GJ23}xZd3@!p`a0p*?1_6>VSWHPED# z>pp7xC=?8zE-&Q;TMyYfaFy~ta~ywnI*GOy1G-fqfDNbl;+qTjZ|!X5XvT|2p+Zq$7l2Y&IBDtkbLzJsC_UNbtC11!HdmzdvWR z+~iuForTdsE*Q6f0eGhM&S$gjS1{|}5#P=2hil_I@ZeP-X=n#?x_D)prwL3=glRXV1+Ehil%I^&pEc>yzqDR^hH8>m>l@sUVpb4 z)71kp6O*h%zCkP@?$!5NC^#WsLquKF2O2Q#q_)2F3o>CE1Ev)1Csr+>4H_TErKr** zMfNl0cxf_NE=o{A@XhZxFPQAVH=F##FronlORt*IJT2zXM4qCgBUU(_f1j_qdg=w9 z+THTvDRzJc1d;ooQKYZdRlJro@iuW-z2yRTD*tNX`vxT;Os1K9g2=O!(BukZ-iYiD za>A%aXZhFj^2B{y%6YHuX1n~mj8uB)v35JrMibb5$VQ&5dJ>TXT3$f>&-JkNehVMX zNZ3AB4r3KG+zNCA(Tf%i;y0^``L0D$J0Y2L3@z9|Ml_W~*}UKlDrIJZ48 zh>!d&Lyj#jzeGp>)_YY8aJ|xO1K+|&@`QU-=Bfu5=luO8qyo)xr`xJGtJQxom1Z4b z_JZVosRFcC9*Dk)^5Cvo%DT2zgVrkl`I3OfeaXw9v_4FKRORl=V_yuAqn-2W9LH#0 z4E^{O@+l^maVQf^5tp@hsp*h~yhwF+KNnO9oNye#-h)9pa!8U$vTIxQ?O5-6@Xq0U zQ8Tft5)boOv#7I#vot#iSt%!EC(I|_CR+HF?2L@aKZbW+RtO)~uAT$TA-!3-Fu}FA z>C>agOT5*isU^D?jWvm)#TjqvU> zJIO-u@eh*B45 zBi!C`uea4cgU@n6mO$(T0tJkCeu85hi)wC5V4E8UYL|X$KUeMc+SrAuDDA+67Y^s2uw_=sjz8@xU#3ucKmawzQxoc9WP)<)o>k6*#A zR)5ewdT47*(cb20Gq&=|*80r;TyBmHZdfLaN)g7sbsQnkP+zutx&ApLA#fs_@fB$> z-!uVeSY$3L*)Rm^D%0$yskESItZpND=}5=JU%&EtZMjC0Y!=R6L7$9}tW`HnQ2-y* zK)0w?+!b;i`qC--%*=pcs|>;${0v%RB8kd{Y1DZsZ1dew$AfkuxX*?E)aq-eYmgg z->!OtBlzw3#Dde0HTTm>VR4L%L_bhIX?za_e`$jZd%|DIl%aFsiNS)}QWW!rtJ;5s z%#gC$a*pN%p-pFhc?J0|Awk-S+eA?pahj{DoXs#d4q%*anH?-zVXAWp(X zl1k~pAC(wK(TDISpupCr5}nEs?Vq|!LmZzxeR%+s3jC`D$d1?l6-4SHxCwv=#XMX0ZlxrX!zj|@EinjOc(FnQwZubWA#u-k8ec5f@Rs**>3f20=P z)pyQG%r@%DD{IZz0Gm<8Q4G?mDoonW-!)9?Qe^FHe8Y!OAz%((8{h$eX~Yo}S{MKt(^bGxXC{taPZ__;)SD zL;t8syR-)59#F9e>d|tk41CETWg9qAD6-Z%eevSx`-A+9wAMNm;nybVAKq#uC|uEp zk^})?7_U(0m!k}F*F4=AV)v7Ms4J2_5SY-KNE#fKdqI?OlwM3816KF%C+yd1F@gjK z+_;4F?eAQQ&X-b!v+HG}$gWxJd5?yj$QRixA8d_7uz%o#f+gpQmS0ZzihF#H!V;c> zXrEuiTB#-evZ-rnjA^%a(<2Rbvm$fxi=E+gLLcD?E*8xax7A-X6)K@-sO)$!#H2uT z&>DM3tdA{*7oYD)%I}iUD*EcXinKJg6#BCg=?+_ll}IrwSCe-8iJwDg)C|4NbV5&c z{)C?AA`Qt`)6OSb$S8(VKD;M^wihO=$5ND1pJ8iVy22$luy^})-LFQy%Z;=7SYG$! zWjE7aoBr-|9UVox!ek*A`_Ty&I&y8Y`u(POOT2k#5o?G*Y`I7WfiCsLEd zhdoxwO)5w|l+%2{W%0?^!;s?G3=O)=o`me(pOgJd@_!AgAaS96)Fgm`B~++HloF7< zagm9uYDew(AlaDN4g<|!6aT`vL+(TR+D#`J;?FO@8-CuVw5O^Zg`8!P@>8DmROi}j z5QM1@diyNdnNd24A47kvyWnp;-G3c!tHr6-9N?kMoi>c-#M2=M$#qF#E9je*kK#$O zlD^ii?5cqp2h!Lk?@ZuP;NAh#>_~s^Rb(iV>XuNY11`=%6s#2h#GQlM{QAjiS5J?W z$stz|QHDgUW%=n8AKgC&^E5Lz)tmV!f{bf zR_US`(~f?(1&o_LLqk6 zovp#U(fc8TA;)WJ4#&v$0?WrJ4tR@ipzEXR9%bI&0GJ+K6r%9lkGrZJXBUclfpakW zF-)2L7Sl!3A(-MQAuSp$J-J;UzvcabSiwC2ntfeVOyGC;G{M47c0%CYb?xT_miSJd z<2*s=2E+^WAE}=QnnpHqeslEjWXt%AUd5F`Ism{7^aP|7#S29f_-w%kM_KeMoJK|k z=KeO|6apwV1#>Bs9+M8dFy(e)nFM8O1JL}{lzHl35UUn{^}ahtR|vJ&KPvgs4aOv+)Dv$E04kk0|2hPFi_P}qS1iD zS^Z$>DlRQpc<60Ln;%-gP5==~ArB6Uw8vjUGst4zdc7*PSZv#>>yKtcZi2HaJ5L^L z#NypUk5B-_Z$eh@Oca(cc9a#*&MRj(mO@q4x>Ye?x$Bot9Nni%6D^-%6JPgavGdFnOW>LI&1X zDDrGe9{HFqBra$b)n?j@BxQ0T&91G%Zl-)Ej1{&UE(Y#BoUTma)2l_kt)bMm7c@=^ zngC29{ukt=0H|Jm^8>LBVTsSb=@*Xw!{0CGNP-=tq)7KG+v%2?IC=Z%nngxSVu2O< z8~-oz;1$uk*Y#X*3}+&A*Tva-l21LX9CTi=kcWEweXrVFAO!)16>~FR$06dM9h=kQ z-Rp+H2DbH9Cmu=Urk>m@NIVMk?O=g|WWW775CJg?=hMAr{30hFQs6KLMEyUM>J2(UJq`CPn{W zh}|I}Zt5TGd)VBYF2}QlQe{nTe{`8O6EJ^vK#7TfEx8VUFzK%x!pzF2nE5P33E3%u zMF=@=0nZMULit@~sAJv|=JsTA61B9n@p}CV^twL@d%+^}_0Z0kELi6!jxI45VEUyC zB?*uNEst z_K5=Jz=u=JIC8dSimY*8M0k&_jNl`77qz_f33jMhYSA&aL6ofMjchO^4SlHg>b{3- z+v)Mp#Ueu1h=NC1omMLD$*N4>mbP4g&L$e4v%zX9YK-M#C6TNa!OjVrJ`hzZi^lI; zA5)DFe*@qf7)9oBls`iZsakqNI1F#eO=kj`jhZ$ zGt}EFaKDXi*2%4>B? zN#EEWbXIK7eGgmEv2Q^;b{`^dbH0Y|jv*hTt@Kxmt4=eH58ZUzuD-wZ*Ho1| z;Cfu-J+(B%%7j7Tn$!a|0oVhyqE1 zzED-E?BJzYS0rO(Ps+buLOjpk{ZK*I97w`xp&E+Lj+l z+F$HGpBHNyraAHZ{r#n)-(r)Mwmi*HMu~~qr@L)lZkN|ZAT|Ob?X`A)^ z+j$Rr@Q&6yf0-6qK1yj$5WAi;H`@-|x*Offvs4pc;Ucb-xLYPj;63fh%fEz9Ul_yB z1!|Dm{%hU0Lg|{!nbBz`ccIVqMxT8pPI#y}Js%a%OPTbnW}1r5@8^6xT{-pT2&dv* z@_70g;$*)wKMbIr#`c!G`u z#5mL-<;+^k^z(YVwvEK(;nX9aUz;NerTS?BHAR*av^AN>;2#~!{?1L~3KPEQI3H;_ zM|$b4L#+%}^2|eHLT7@OI_&>S&5{2A0^-m|!}`2PSS>KI$042NAPnH;GA=H6K64z9 zuv9n~tR$HC#``XqNIW5Sj`s~#R##uC^7WZ^dMa2C6mX3|PB^N#-=kJUe_UHnn<_0@ zSb+&%c(Th&F8<6ITiM3;lrd=sz1J^8SgiAZ%=86Kip0lxGDhf@c&f_x`X>J$3pK&G zgv<9+iopZO3DmegR+=+An95VOQQWoCj0vV^Hn0are~K(Oy^$-{1lz5LZYP z1jWEOYnrqYM!>0+@;e3GCm_@RR$5x*`6F+wI4WxzCbn@s=*`$;wOYsHN(L2yBze;a zb?H?oQCY7g&umEsJeWHx=Pjv;J1zp*K+MsVkOwNzdgB)bO!bzz%Wh)pD8<>N>{P+t zlklmAl{Vj>=U*zhAWV=$2pI$uDF1r_PJSJX#_}WR%c)4q%?@|H$-iii0p7 z*S5>IJ)Ty*vnxe-|FwVzJEWGK0)?#l?%a8^aX6CV3<9p>YUlztCwqQ$)MnYeY7p*> zF}~Ow-&|TBrR!-R?tI}O#Tj?#Yc#(sWqD+^YO-o>LQy49Mek%;n*5r{<&}$WH4(=L za-jS}+39N$Ibrg@N@4k!>huzZPA#fYi7(d{u?{;O3-BGr z3-E^2l{QUHQ<~!o&Tfd09tA&0E{pDLL=569dokLteV1vy6}f9~kW-4^jGB6pbMbcP zqvLEYN6_u~kZ#LwRt|Z*FX9QFMMbQY+Wqdzw>UJxf8) z%ziE5L|Uy@1{K_9n_@cgOO99fIoHAXR!^t}6|L&&7?J@{b#WE1XX0 zUlnJcDMzxlV;*F4{l01Wy5>9B{{ak>Xh6z)9&?KZCKf^!VkFbY+FDJ^b|z&w#jH0E zX~0f?FHg57siWomf-sr!pNe+>3BHiI6ue7dwGuVFr2*q^R`>c4j*)}~M%?_6)r-P`3J^81^s z#J>*J-jwf}P{!mmamZDUf8P#vYgNPB(piqs4Ulb0U%75F8!~JrL4+aSI|~4cc~ctU zE|ZB~*{ro(ODsFo95z+xT{3YnaTpPpKO}t@bc5$doLiBJwg=!K(guN~39{G1CPP8a z#bP|@8%22q+jB0iSQ^|qH_)`EAi4Fl5Y+;#QOS{4uQc3_)24U*c4gzG&EU!n^7_w( ziNI+S>_~VRTV$eG0G?Dvq(Y<>|7_(2{8t3489gdDKACexC3}@v0l%*?)^t0y9!lq> z<$@uZ91NOvmN~!edEO!|C8acVMjAzR!+BVI7P4t*-?BFKBKuxVZq%4%IpM)uBNIG5 zGYGSmFyV2E)z~LPzC+gTF**)~!th2`volm0_kKTw#(DrqI^-YX<2%#3NB&ONkQy|1 z;A=E<6x_chvQ<{2rI|nrY8&`3xr4?kp4OaG6!^P2a5(0L7Z|J|TeKQ$UW}Z@5;KP{ zgs+1qW{}^a_$Gj%2a{}F3oasjaz9xRL{HBl(aTMnrvem7W#T500_$A#SYrSAV*pt& z(w1@1Z)=Jmj8`vkt2jOa3#~3=8MjMF`jN0&)3fwt2s@9ExlSB7DwZpUi$$`DzS45tU0FeUH zoz|P=vz-VcOXTN4OPbPws?`p(7hZwYtpK>#pA$eHtT)_xw%U#-20w151e44X{KU{Q zJ76Mn|FEGMwYU9?X9QCaB?v_fD*$;269aj_$IJ<{;-#WjVLyswarsMkYMzX4^kFg+ z-Z9XX56{Vm-}~|S2m9A=qzmF7laHU77sgg)f+cN>Al6V~AEMKN$C8z!N=S*cu zPzfg6#l_aVw-q@46>gm6Kh=SG`O|Rj$Gi{q(1V9%WurFTS*ou#ZCTb*r)@`q2_;?& zt^?8m+C@h>zSm2qfmFZ2S`Yy!0zaSqWRj%X8{FR z6fXWMki<~`=RD}R9|(n_E#5q4Top85PVdmEiB!u;zqy zU*Hh`ovZ!v5iotyv5M*tz?)lW0!Q8WfYw`#^zy)TI+MXf+k99_GcOqC;VBhvd~na) z3LH|H#Pxt@pd{ZiBoyLDwq<^6uUd09l1vSkZMh(-40pj0v!MQE zw8JUt5j(f)3*}HONQee6#+BdAhCV^&z23%EaPByGiI_fk@%iL_i|ZnFT$yQbmHWD} ze%nb@ZP_o?%&ezlZJPHp9vC8NuoKY6{UgGdf4TwoUr1G{@AVF}+dgk&(Z8 zh@kZLJIfd%6eNx?I2<(b(|1VGF4e7bp#RRf--PMt7b0%2%iPpw&QBIEVqvp1P&ES` z-GP^(0L2`*V#fogy(j0jzIvjJ2LgbM(q{??Whr@yC~c>%OQsdymvi{y>u+Md5oWfn zfsft#r`h??!F*PH+}>WxX-4l}Vd%eoHR4vZ6p*({-|Nv&$>Jh@c!<3=m_S@uDtS_a zNpK`y=>!p<&g2%q4>t9gkUq3d@VrbKqUL#~z+{T`V+>GQbKhs<=hLz_PV=uGP9v+; ztwzdrcP`7VC9%on!9tI^^O$fPSpI%Fy{|j<=d7gzmR$$GqP6;dwJ98qamg<0lw-&X z#Nbg5ZX+9zKR4UuE5r^zkw;qfw917AX@)Re?< z_m&$aEU!PzeDZKzeT`3J0ENA1vo`8I3lX@tAI{w4Hp;n!q1SiR`;XTCG`(=MA7(A7 zG|9_ZD1_3BX67Nr;rchu@Y^o}TeBXn7|^cXyE}=9-z798H8+!X7a=uTv`weNeUvTb z9oaFPvGP-~lOd!G_;4@F^X(cv`W8OVtq;>@-X<;v2Hx?l>r=FnH-`6ETZVySBsf1h zf+(+3>Rd+m(lVuNDdtjkXPzSzg`f!Fl;t~?&})}*|3@15Hsl+(zxhC%LCiAUwNe8Q zL+9QUE>x)`iIpsQ7ZeD)G#OPS_L@qk#WX-V>Fsj9a7y&Zz`IcK{a6h>a{K+sdOfeg z-lt4|ipu$O)DrGN!|X3x_li4McH$OrT>=?p|F?=pnXJJU4xoruco zA2+BMkG5(0C3m=?`9|Km-xd8!+Q4D}MLYi@^-^OV`1GykWizs*3K5^9XTy9Pc80pO znqp5LY2B8u`5f<2VFiUsdB@7bin=7lvK|@=g}8-0@yVM#{)MldwKBE&u=hZJ6SlV4 z>3}a5M-6%iyOk8^&6UolFsX76!AYxV9zo6uK8um{W`55G5Zs$}TWUI`H^di9ROZ}+ z7cDi~&ga}b&V^X|c+1`IMuFIzQH`w@J6(QroXte-w9O#+fo{<6D&B$5ep(H6%?hrO zuf_%oxbN;WY_qjBLc4fJ++-#*TCtx%)95NYd28f*|G@d~j|%GEwBPucLm)KOkbwH^ zJf-t)dUS^ju#Iu<6aAf__TcdS^LU)6SJNT zKlZe#&5079W{K?YaVGGpBBKH%B*h98_AM*-Va34>aly6!IRfhtCc{~K)(Mbs(gLwL zum~G#p>`4@S8mNobX9D+r`w5?-Wt^AbS%Ifoczku@9M=tE}rRxN{DSo|MrNok)9je zBS$7u&&O9c6vpvKE=0xCO?)0T*t-jYqMGb$@RCg?aczMEwitkSQm}wAlT$2Ih{7{)fvd*&;5f=7-l!_Rf%t$|bvv zQv!yRNzSRoPo}bBrOS=-#B;Tj#I-7DZ3L^YtB#H%mubSKa-fy30mggGgbFG_m{IZ?Oqhv2RlmDBXiKiXVe@!x%>}aobYa3Kn7dd^DjsRNA~HWH>^H+*^!nYq-I`rffG`RF6#x{unj09sb-*m@VQOLsj%wK}00 zj+r#-2$V4aC=kK&vkGHKR8<+yzqX$;mSUD7HN0<(&Z!bZ{lntpOK}qBX!6t6#I(ts zat3XuD9U=pNA-*2{0yk5J(RmtPcK)(<=mKS!1L&_I|Rw1nCRRhNx4t|g~g#!+mfD3 z{w<^B_mntEBxx{dR@Kdh&Yd}!go66&vz$Y~7SSrV@NWcl&RmIrNQx>JHwnRg>8vGY zWosNY*V2IlTtsSxHZ-N(#vSQv0;>PS{*0P7!35-PC<=&Xe-=oNB%)uc+Jpq-s8l@h&u z2C;6nTc)tZ#DLlMiwWJIH|LT{QgYK(97(>9??oU6n;81N!ijdo?M26!17x|7<9x&0 z0^%%lKD$P0ze7D`_eT_HdiXtB617N;d)v`>7I-c)^RM%i&hip~|H-dC`cyS5jeCVX zk=2TVO1%-muV)r(6TlfJWTjC?28u0Nnb=^=)>J2)*^o+Kk}e$+|9tc=cIn3P`$+BB z9K^j6`8I%xMwx;T`g-j5{a-BrgdpU@YwcBK6E+v_6U)TP8N8pE^~hf6S6xdVYxf9j zeBBBA(_+U3E^dzr9fRE6;F>RI%d%sy}o7 zC8Zcs5)pZ~J$x~0pL;4NMJ>{!YcuiHJ;?rxb=hMJc5E?J0}9cVXZcD8cclF)qD6vt z2b2vrgcAI-QSsHmCkfZt?PUvn!;>nK`9NXrXOYKDl{7OhX-I)uLf0h>*@u<_qa}%b zOvi-RMZ!gEHC+;kWpG~t^&n0^_J-AjZVc^4H@89kKlQ{|o#|Vg-b74B*Gl}ec;6Pw z`H$goDcSNbfXpspe?JxiB^-9JuyyW&hZi9DHu9p zsHq1R{2TtSVl>45Ck!!A4En|9nWJ)^HELc_bR7_0wI_+gB=WOLX-;|iKJJt)aW{$F ziPxGXF<0%4h=LMzL}~2(eNSvHdSb1Ib*;-l-Wzi*B#sQS9rxF!WH`@?v9=gm2+>`h41$$?VatDSG2mE@Ok11XQWL&gc<>bk;n zDx%q70qOfN2n-)A@w!om$cST2){df?Z!`m7ElsGP1mH0pxS3gSX?z`$^-v}KMQ`L_ zS_R+KRPzfV4=MX$<7PqSU>s2w%!LZauj2F9-{qFzvK#Ok?-f@y&1-m{v9;A#uKX|* zHOCLtC~5K}RdM<0I@Q|mG>LI!Q_CdH%Wm!7z3UEp9u~{{p^DuM#}2J03|%HvMk6|> z$#Ud4$^C`9cY21uwb$MV^wwu6oZo#^{JgPw@My?-XzHdiTykn+j)DT zVTp|>CJ{6pKybij?hD&Lo>qaLkkhA~9|r(uI{E!)q!hb9D>E>bzrw~y)c%KwpS@9b zq*o`@FbQS5Wh)XgW?h-REcBB?`-Xq+ZXT>EHI`)pSJysmWC zuB!E~)QDmlk8Y))$nyW(Q}|akRClOKv;kfhp;Rrskt$ZccHv|wdhaxAD4Lk%zMkd$ zRY(ybgVs2giCTil&HSzxT(N#&W*VL)#tSt7t#p3+FNuZtfNtWaaMIs+1GMJ+~>etY|u@RsemJA$G%E%?=+nLX#m>xAbE z+t9{={;FoLn-b4vsS1!K?rdkTnd+g>Okx&^XoVmn_5rp5t{83rN*PAlhTVZ7Mm*Ad z6h$cph`r%ygCw)~3~iga`+qH4;F308t4*Ouz{)M#V0_YGf*<5m!7=X_KJ}eZC@~D7 zI}Nx5Ff+t)lS>W%lw5MO&OJ{|m^Id)#oWOTh_qm9zOP*maruoS}a5ZdTrbA$J0yn*c=a-%B`f!>O|fXC-_Q=0&>=K)VragVjS9EJXnEI9WbZ+ zJ;*qKF}^Te>9LR|o04*Bf7>Wk6`so{c)TEK|}UvnP{R;m_C@95p$q5g(pD zKURD)5}N7ypx@Y0oHFaN9*KA7Cq?TNQLB+GxsS#ndNk5M);O9&r=)78y+~I7xThm; z!>LSmh*RRfp3!%5hq84Hsw+r2l&wLUjaNB+y>qcHK*au;@YAbegMe+lCx`RB6FC`c zhRR$YR|2J*ZgtK&P(mA42hT2gG;Qo1;iJYI!LGqg7SM6AJF^aEb)6lE#UmZ5QD){r zMc$pU`+*<-()>!gbbz0&X5R}nfPoUUH=RYHj^B?~H$4K)9i2`-ndNVPVfGn1^8NKv z@U;Y)L6WRQf9J=zqD8G@+rgI6U@)zz{4hadEw(JzUd=2G2Qj&SzVk>ohJNAZ<3^GO zMBooNpB5N&+2eElhoFa>Gsn_nO`3pLaMr1IrkaJy$+r9q`D{QUX4}zqb}>J$Z6R6$ zPg`4}YjkvVc>Vzr-tp7Uv4PtTsqEmlkd_CU7eY$e+}GRh)y|}MK0p7)Z&RvoeWtRc zC8O}#A88b4e}QV43b6SR$aOg0Cr@?Bqq*9mJ0Nd6H}TYUenC9CmGfz%h~wLP>9J&6 zq+2V^P#K6xiggQYMo7>+$sZ3wE?PML2NyljJkm|h2!4R7^Mv^aFBDYB?bFhDkt-6- z@p(cx6Mmm0>g3?(^sS)siK$%hat>W=g}$!pj2eKqV=S8y!O>@=pS%eE!t(;>+t!W> z4}v?G!g^7T(GDK{4y(dJn;UtcMhyO?K=*=9L>DD=<+L%CUcTby0aWc|7!YSTx;2M% z+tbX#G6QE;gLVL;Mrvsw3XEq}zfgAU09RN{J=(jborS1>bYo4j+M_q{KQ z5lfmio7c4G@1Ya0mW&W9HIbodb|gUI2c$0@Idi2xx{$~ z(t0LeT#d-Nyt(F;4p(WEOuJXUqU$)&Ep2sdRHZRL8^?r%S~~WmNIUlyTx?#E+dI4* zxmqT~)gdiEl7JOV4-$XJdrlCxq-eVpKGSpj7*)ZQn30&O z0EtMgmZ_6&sO~&3BgQVwD*u=iTF3g7vs5xQss!j@u;xtXfbKw5H3Oe(af3n=KNc}A z_9o0C33|Uy}f>$1f*bMmQ>2{_sCWnuJM7%Ybdk!mXClu49 zKw49vpM*=~`9qLg(8YoEViDrlYMgk?xdNs-v@7p5hr=ov9joriA` z;yo4Rtp(RAaar)?$fx4BPg5bUFQ(1*CG7wstK+0>bqO@M>#K-T;+Erb<@UPt5&maU zRohIEKhb}X8Bi-xLl1vJE7!`HsqU1Y2s>*XDM&)~ab7Tk;zPeb`qnvoUM;tGKo-1} zt<)7=j~r8j&&V{Os9)8<0wLta5t26r=KI)5k;N|0c##=1c-G{+BH#Bv$p?m|;tf;5 z|1L08q25w79x3=tzt*Uff2$So!c7MT9ALE{~w@U+QY zs}JL$+`MnJ->$q1AC6wbV>$$ZD*etg!-Vcv8AyWEiybIXmh4uBd?&Mx<9`5s9SAP z9DDpwcfXirvT$d9QaatQn{(A4Pwcc{SFGN5jc2x9y4Nk}Nq=_NP@&|Jhq=!8cAb

    GPf4;+ObehR=m>}GkO~lUAdCUWD z_1mo&zt={t=LOnt{>m0HZ^C3yp_soikiY5HUD7Fv$PGMcCsG{HGX>g}(<1;X6uGF9 zF8SG`Dj&Y1pG+0n+MSP4Y!0-TEu+LPfi~^D44W!Ovk?u5D0Z;a`Nt9E=^{h)t zCKV8sZlv*dpMyLS*qHGp*SNo`;YSy}@-voMyx=6B-Hf@N%=jEH`;Ap(ta2mb4_-A!k;pN9=bDd)WGQk_Fk>p7dicX2z&XPppCj}t~G%*d8KG%{Ku4oqY zJUm^2-bW}q*vxH0yi2C%;azJncVHTj+Uv~P_1zQv?-$0O4auGH;O z0|Ng)HD5g&f^IxSH_uZWW-b|S2iqI97wIr!@S5?zxd*ra?`;_&$9Vw@|C!z#y}4oq z8>0d`B&?D92Vc}WQ?<7owY=k>+t%|MUa{rY_t3tA?-MDVV;3q7kExin zOpx0y_LZU)gu9-pP3$Ujz5=xDeph(%WddG zy2+$0iTf*Po9O#u#fle78@%V}@U!y(=YYw;au|P3dN=+x;LPqZErAwcuImqJI_Vh?wCd8= z%oUEd{qQavr3+betw3P*RtI6*V$KiuaV{)l41le+y+h|y(u2xj%o-Ors?XA5uAQHa zOC>)Lrhc(soIueOc)=cI50oy5;0bndc7@K0og$~T&4w4UQ$s^lv3Of=Hvd{|>`PnY z(69nDux-ZISms{)>dZK~L|OLS!2^kLTC|y3*kc!QI_`{eE^Z)WTDjwQLHXQjtBx*= zlitIwvlK%t+4}_=mGPU~d)s zhwq6b=XL(F4zq>TJlW`=RYOrcDWc}kdXFyG?P=Q+TyZWxJvZ!^o-?4P=eD)aouU5A zP~_@CkvI1}MEc6 zM+G7?)BYsf;V3k4-pzV9|{tFR~1=3ai=O1}f)BPZMBkY&uIJyjAAg`P| z)fnegJv_5J*ed^J`E|DHc*(_D!7)!zes~6FL;iHK zzVRK8PEGQ5O&=7(I=;R-Dv~Mj6+1Afil!xo%hdYqldiM~-~s^w(SC9iYt$5nhjz~O zqY~?X!~mDjRf#DzS{iKwh`f~0`7n=jkj@f~@(Et=k_d!<{EJ{Jtb59Sh{+{JVfY7x ze7k&wRkTsXAi%v@ZUeij+so^mnt-e8YYHPIdB9cP>`z+Fd)X?_M2MsLD{~kLKoVbKl)3zQn0U;&bLC;r#dKVQI6ZZIq^Rvq0;t0@Gq1l|%S5;p{std# zDFCmHr+Jj@kWm>ZROLm#MoEB8uoI+?m%bm;DyZB@W;bAjEJ1hR9t@{Te+$^c9;OpK zH+OZ0AVpj~^2qSuM98Ae=dHm6I&^%`fPI(ARHl4(Ln`~^O{n?H(=xqYeUafx`BILp zGd;F4*Yte~S>GelFr@!a0#w5P&}ywOG8jX0kQT zPkB@~IYVN42#M=9h;E{{Knj{1I5eK$6N|s<@b1lsb3_ImymIO@nNZ<$8b_fB|Dcup zshQ72=O=Jn4X5r~9(YtzlM6x$!NhTK%_>XMc&Sl3YJ;Y$RA5O}rsJ0n9L}xQmwY=% zB)&Z`KBjrl0G0JFUd>qj`yLV7$I3Y$6l;W~uFiRnoOWq_U=#FO;$+fHdS;x_+T?Z% zZUR)(|B!$FbwUB*fhfAX9&SUhAs(S<+Eox5@b8anVU-%U^21e;UtW69q$eujNtwxe z%GMXjo!=Xw>x%Q5rL(qniH3HMDl>l>34f4nzm+e-S2H128HxtdsGh>x{5YDDcgd0E^0?L6G64F5F{ zz>h20=RTM!%5)jIh7mKN?39gS~lAdklQZz`w zx-F{Oji-w-@=;EQ;jPvK(xKKNJ?qG7X&VLk8D@mZ;!&v&Zr7$Rxj9X24y2ea>vox} z4poW4L;RGk3{ry<(2L9LxL`9j(XqAdw_ozSx5d+jYbam+8%YeXsJH*#WFa)Yfg;x2 za{&%2+o9ii^~j7((Dx%n$exCMZ?qi2sjybAYkB>1W#^?)jvQ$_tK;}B&VTOgAfJR+ z8o*3&vK0A9iP)4h>t^(cOJ4=3%xBZAfKf#mYoBP_-%fQ%`sXP8{C-c%Z_R^SrcW+R zFng}S&DMkQ921mg2YF|I>+>B^m#<0|DiX%;jcr#kN3 z>1c6sXmdd!B5E~Qb5)sX@n7RHzdM-+c@HdJdOs3c2j?pflfwRNvY7&#r8!y#Xey?!tq-X!`pxBjw-aWDK;a0MdI{6YjlW`6PT zFxb&#jPfM7%sN=T|%^D8hqB09!y{1_R$Ilh= z?Y*|(NK}fEnXU6#5=zW*0l=qvt$L|>saf{}`z*-cjFJE2z2skh8d z(yGfU^g2K^4i~Yz_1ENMzT3tYm@m(PgD)WjI8XY(hnSCaz1I9}2M4^--VTAX01qm5 zYqQa5eYjl8e`!Ovm3%-PiEV3={_fRYs9_?gAz-s#ys(-%#A%h&T_X~qvmw&~(e^0w zjm-|QZbvFUubz4{NZiqy)ia*m$rY)5)9%;ik;&|V-xZS{_*?F~VMh(^*3B4|_v);A zDddp!33Gw~yoXehesNa~$xA+nR_}xMpo?IP*!6ZStol0vFX#lnA2yDdfty+RaKIJc z#9*3=&e`UvPo&b;Vy4jD*%j9f2zHoHEB3%mev0zOyC4|ft^($P3&|W|+mG#mqwhXK zoli_PgePbj>=>#7dia67F(bh^-Fv^@puxRtr~DyUnalo4sT>+S7O{2B|7L#;*}iRM zwfbzN1+P)`YYG2@Ze#f$jJ4(pU)*gotl6g_?0W%6tMuQn%qT6c>zyELhxs=H*g@l- zu4@k?a;d?WJHF*uET5E;!dq3$ZEgzjEN7Ua`2~&Xb`1~ut*IGM$wp;7gcy2VIvs1t z4m!!h_#*WAV=0bZ*3b!i`EC)BpAFx-sm1cwWo74-w0Deuxir$v-ENurh?p|Z_1r03 ziN4>S-8v%&&w!BNfo&M?%e9G4fEK**`+c%FIm?THW3;4xUgr92YK#&%jZ2?QTyoIM zr6T4_>?(UQT`Rt>)L1vd(IB)^Fl%{J@z5C2;GNrj&CPR$l6)g{{^Q0yWj?<{KHg(? zKKKUBt^Mjl`lBB?)ppz-u$>vWy%b5OA@CBdrppUW*v1ba^d$S!NVZEg!mE)$yO|A< zuuMo)>cf7RDXgmx#UpE3qqsM-*_Z0HLfos68t5IgaPG`?JdT=?u5$=dr1h*E`L>SC6ta)x!=qIGqBsjPN38ybZ-Vv zhKv_`v>tLl`4+Uig}Nh?a@kMe@y*-C;i^Nx38INr`qWgGI6pfP)RbHeWP@g62}*d< zUNnIUJT~p_;@)VY%HUZNgE+2;z_~6f|G2r0iR7x5XVYo^t3p#$GmG`A#yt>3lJC*V zLlEXJ_+o>uS7Z;ntsUeOeN*0}GF2p$=#dg?q(CIlS`xi6dI{?yFZzR^=jZ_wAClxC z#($9-3tX`6)Ng8nuNkXuq!t*j9?cN^1upc7f@QW;za|)*TcS54dKhIgB0b@MX^KiH z7p-Z{(Y(n7j6fSVg1C$6H5=aw{EEF=eRoBt z{janvy~G8my$*@ZGPG%|28l4rc}GQPsI%t2x-aqI+gvrhT8cYuZvCEAMU|`gwPOR> zP4*!_?fv@aO9^+@4bhVGSDzoq?kT4CXi8HWrmh-Fi2m_um+D4j!XyGte8_#x8zx4L zn{bPi_I7ZEW-TN)MHwdHX2RdTBA>IamnQ*ZZ87@phfpz1#>1V_mH%l0r1PlXO*i`v-Pf1pw9uLt9Oj$IK0RNsgTPGek~fYfj4fzf z(kK7G3HwW}2-hMec#ZJ|$^Ts6M|)W4S+JwD&DOhMsWss%j_50xB9_Y-Y-~`9fVP?> z`t}O{#QN=X&j8nQy8l~o)Qv^5E^H9d^r+GL-avJ!zLUx754leSIdxxjYh&@0b#ixM zUi};+4&psoZ?)xYo%5`2l}Hn}_3cLsUN8);MDa@d{NATpC520k_x{0J#{7#bbd{4 zE-sXMhp4JBEt$FixN4Nh)VW8~q@_LVo6sl;JZqruOTb2gXS+wr8p#njYvtYj_st(h zKnD5ts`P6grY!HzY?A7J{nuN<7b}tY_kxRItu4LMM8cXIJ_eBlkDMfX z>(p$0o}*;lUN{l0^|HmNV1FvK{v^|TyOOx}W%$m~W}Aaw0s65mhU8KC1Y2-sU%Xli z1`j0|M@2@L3eIZ~io4(ClzulGLRud~ChDzNS^UW@GJIK610gW;02LLx2e-9+y!dhT zN6QN!4u%8U;^lx2^n1jVx1wb~7rZavTAwtv74JR$ptJ%GD{9N&0OK~@KlE)No@8t6pLR!ued()oZN4p5 zVUtW#9R7-l8#WzlhZ-XCLf}6VL6Ifp!MDwG?xF-asN+MvA(yFO5tFT*hqXPie4c`w zg_1$4*Z!K#J%iQ9G*vpFgEBz6#el4{Kd=rv%r)O&9A(5fvOhj$l2SSuia>8j*!Abi z-Y~hpTG_V7lG*8zl6WKH3vw7uW17yQKM5HrO_Eh9xLHCB)GX8KOYuVS$|wxN$8Eq> z`UQ*8^Ogt0ZXe@CM7#t!m{4KPZgKW*JCf*O^9x;cHA@bZ^f$ZAx2{_czg<)!lq&<3 zs)Ra@!Z_i^@s$ga2B}eu6y?&}zO)bj4=9->rm$c(aOrQWA|5IKYt#LVA8bA_ZPjDrkLhtBZeG?Q5= z^%2wfSCHmfA&}h%#%4O~`qd0;>Z6&+u91ctRiqI7U6;M5j{kXCK7buOh=H9`17%px z`q+DwGce?ToXzwkrON>rK(%4$q~0UFX(4yr)17kd!pEmITUjfe7~}ms(nA=Z?P#|B zmO&c4Lw>?j#VRUFmk=<1j;=l{`+ofg%2!vEyzTA+-IeZ6;U*$ zQNg}&$5Z+=N=<|iph2klOY^TEod1BKRnSbKT*IwXp`Ez?Utd(Xl5NBxkrQl`1HzVq zBR%|QiAM7t?DKrnZN5ny$k96~k_~H9wqDkw&QUm>E@y%SH%wpx5B&=DVCUH3{2`tx z#Q+DY_^B={Acy(#V*j70tRUbGso{z-`6Z=HvX87wW2lW1fq93P%$3yd;x~UHRQ2`# z`&;|H#zPZV)&0-z)0nDM&>U)wRt)V`M9>J`Jq7L6j#Bc zkceDh8Z|)`M5_eVoZZ}<&M!&;6o>j$5JeAOJs=3fO**G8bsb@uyBBdR{u~KCsNMEz zd6)!I{fGhm2CbiT3Fwgc!hjvHdXOq?-99G!<==ncjIuy5EX>;&j$-;)X6#Zk+UstWlb_vZuLOxHP8m3ZiVw6x??Z`u;IM1bbhd30E2c+zldD zNcqU!odQBu(W3)@@RgJF|EG}R#SJR{<7Cu*v339`c@Rv*2cWJ*1vtz)DdNuOj%F<( zH^Gl}G(IsN`;v2fG~h-K6+dlierp__O988R)Tm3s$?2Sk!-9>X@W7wmb(YVkp6PEk z*XwUXCJYjb_sAnEjlL(dp9SH5b{=P*-gbAdSEv6J(9r^>rta$#wYWEb#R|iJV@(N6 zBrQOMbK;1EI3Ru(*4~@^@Z~uG3?_u)Y;RNox)tB>9O!g>mKPD_(KHm_e0O>+kLiTQ zTpqQB&7L{+h*XULtd?%RTR*e^;0;jeg~R5IS8jkWh96~5R1h5t`$+EYxCcxNx)g#{Uzty|v|_(Hei7NQIjea|n#T${g+ zxg|%I=ToKd!nXBT%tIF}^op~yZrY+%BpRxbDEzH9?8}2J4)^^p_o>WZEmyf$3kmPx zK{$7PDzE%$yn_7*t_MY*v7>1#1BrLETzT??pSK)SB4+r{$3CeNT!LhYQwL-psLaQ5 z(LAC?jnsc5uzEKYwe$@ZGz)PZdQNzliHCZ!p{!Brc*YxH>r-<1b2G8;sxGTFdB_og z4_AKrK&e~knk=78SS+awKQ+Mb{eVWzIbNmTb&UCso6oGJ~gN4AIuVuxqC z-=-LDy#g8B=@L2{SGXDo=sx4F6+}Jz_-Ma+zG8KXi&h&Uz{4iqp z&P{bJo+bg7?hBY9BvA=%_k-oORf{Nq0l>5!V&ixM_KWMKI|8*vf%gu6I>Vc+<)dDy zpoLJa1N&#TTf{eGRCL|vWz8U0Fyk!`u(Pf1qg5 zNp2l@<8o5o6(qv56f;4@_)+5$ZPtq!jh5(}z}^$ZJE@O+*XRxJ8Vsrn^8S@SH;GPZ zV*Q{|z=)c#cy9WmfGnagV&$!*uv+7-)E8T@=2&lpD$RASbk88AKi&!c={h{O^~R2U zt&)p_nQ5Bx7gc?MHKnf!=BzuZtZ*e!-qYA}yqw-Z@!yZ&N59(p>>;|xz=8A&VA;*= zhTlPJ@65D(>S7KZiV0IR%NGKZSR~WKx;+5 zbE0n{{j;F}hrDEN-8+81qtiQn@0b2>_p&?$OXU^!j^nvjWDqsl&9t=;?rusDdeYLI z@ZIi@C`wnR{gsj4@uM|pzHOD@Vod`#$hw`sH@y}2-x5`^`G?RZsCPO9i82{okCmAR67ShIe{*`0TcV;8cyjUIsk-Il+~{8U#Qi4CuELNx%LS z=={aY0xiwJ*ZZ1A|P!RF0%ev!$PdlXBzsQ93_rjD(FE znH;l|bd^lqj3KqP*8JyX+|>{NzCpPc>W1Ts5FJKLh#NnKEB6>6*3A8L>3Vhc>M>-D z_d_)Zx`~89{-WqpAFh<5adgU!`q1mmcvEl@Q)4p&JpI|lr?iq>SKfhv%I!#gwZM-1gnckq&*Yf0;>UBjmmv7kM zZ*lQwn39E@FUopmA>J`>`zAe2>{6%yi+Cu1(f$pGwS5$i8<4Pg3z6VK4D!THm`8A3 zWujt-RoT@ww%z2Tg1>!Ca*%$RbsZB_#9BpPi%mHyd8qjX4uPVV$O9XDoPFArDntWB zjLnPNot~8zoJYW?cv#&c(itnBt>wdw1TmxME2`USf-BiEndx-Pk44dSYjP~#cHsaqF;PK zwShh9Yg>-^xTe)#D42ecsVXOYU5YQfKRq1p8+CF5@p3-LOV!ID{JjWU>LXgL%`Qno z&9|E%O*ndYp%fB>lWO`HzT4LcwVt&@erP)kIjI~^!5pcRoJ&uiGD^4I7&XFkO@AN( zsm)ro-7{U!Ihp;mMi@A+;cN>@rLX@SlCt-)Bv3$iTrvt^1}T6P!JD;qR-$2rceCVj zLOQdZp8K=A)hR{j{GXc7_ZbBt5}~xwb1#<7^qybnm_Ff(CeoPp5$LrQRJtp6VN1AU z&o}GL8X?q7^2v`_EsvKveRJt!$6FBJCeYytu z9#A$e83e2j8=7W+l^^L!j4^E^=H$e2fpz-o*c&jh9^~}TKU@v@F1{>n;?m+SC+sdJ zq}@*revMH}cwH)yzpu)QSP&O%{~Uoy*GRY6cp@YbFDUelxq13KXX|6N2;yjk^zSb% zQ@+#9U=nsFh*6h8cSOC@Ce}JW&eqoUOysCp`JYxbdaD6jOTadxcqm(&cTxKNnJ|{h z+{!E8$fdQ#1_ly?r8Nr+J=93v4WY_P$H;?G2VzCU_}vH8sc)u(l{o=mj~+$Yf2}Yr zy(|ZEf0v`FzE{i7>07{U0R*3)5|kEYmaCjoTKBq`n=8#sF7&Jis1bPYuQ-Y0CMJK@ zKc$@E*>Z}O?i;HnhZl~yy-MUZi1qdR-Nlq|oziZtS!z|TQC{CG+~n@`VqsBtl96#L z@&Jl&s@k7!kL8+p#?kZh)jeJYN42d6$(sgUvJ+;th(SN2Fb!gI#9*XR;vV_r=)_Q+ z=G$AsYP3n8k0#pGl3zsfE+Wwh>ghe3^t-0%U66j{ap&#g3ZjaxLBd}>#wcxrdU&ON z8s<-$VD7zS-D{^vRW^S7F>lZAE3rvZnQck)(=B*{3Q%U4w;WecGa4*k{$u=;9;+Nb z89P|+xG%?RwBawjVyT+=nKARaWmP|go!#hn{S%?qov)uiJT8eosgJ{ByWu-G3{zUN zd$~pSa8-U)#N7X`@Z(R~bg9a}8rv7&PAWtClS90xZ@QBRMS<-FzOr>}7tk}jI&qM! z`04&2JD9e`JNk(B5jBlUWiE$oy5}pzo+xsmAz_|XX7nrYUB9fW9RlsnZY2T+{|C&A zZE@xLluDVLoQqSp;Ovb(GUGy1UTxN`dMv38uHq57!3v;r^^fV&&c>DgnAVfoi=F0S zzsB2o#o83|R{+B-E`ea+!p7R^3Hs8``(CTL1vFva&66)(2B%aWjR-}Q?j1ELDF<8y zTrraxeB%qrv>oB?uFh-Qd%fh%ps_a5)|Oix6vJ{|Z-~;&pcsv|h4fc029A!)I3C7A zRaTv68rA%EmI+m<(0^fKh(K9p=#ZW61peFI*y2q5`b?2nAPsMk7beiuiIn#(Zm1e2 zJ-eD3I9}WL24621hV~sF9?i;kO>*i#mx2k*RKQtjV{dHy_4rsB_&BJOIvyyy0}_*v zne;C4wC6B=qpaqvu2{q78tl-kiHqrL{Lpw+0p(yJ7&Lw|P;h=jtwp=6W4yWv2Q7I; zPcI~>6fZ>j4&OauK4{|FnDgu!{2>?Jb-YWQD*GMOC~u5<7ZSzb)8Q-vy&I7sK`nyh zg;@s%LNo26PszXRz^4pN;!pjaLr9y+Zp^uTBZf1a(#Txc-W6(RV|D9GO;syvgQucy zO19r@S*Z74Y{+3>@NeUD;YN5Y+aK$gmO!OdluOOQ$lPs-+b6xUqvUsC#eu#0U(3(m z5Wiq90FX&em4#d*ae=UdxZ`Xkv2{ZRnp!dO*%W{}ILpB&6yDoY4QEVn1&u~GQtxWf zFQHf#joEs+oqk07xQ9BXaW5I3{&-W>mBXdzR~Ac-d^Dqr+JwW0nYWkLXuJ{3^bxnPoTPl0p%U*) z3BE)Oq}Ifa_)tD);A08{Uhju@ZC9$fX#|Zn+av{34q|=cC`$AGr-y@*J+Bdw1t{jO|AH{!>8<=SOh^9j6o>9L0 z<>=Eh?z!g=GSFLHgBPgL?nuqO!ko2-Wxmu?rI#^*O9(T0N(dW`e9$0#7FEq3=7kcK6dMy7<@X`T?51<_o!y66{a?6%AKDe|lDJH7*XXYT9(>O&BN` ze>aa+CrkWCW~0nyf`cEBLGzbu_ImQFT&^iD4O2~wZ27hv`xLOzFEN82n-|BkHOhI( z01S#ls+73^F|vLUQJZ(EGwOW`%P1s(WZD3en1+Uu9`e=$F0 z_d;Nj_g&Xz`N9r-PU^ufz)hV-64d_EkNa5rD~?((u0G3BCoBE8{Q{}~7gJ~Be1aB+ zkxo^{{1+iqHr62h{7W*bOT1Ddm^C5R-k88UwDMX2U49wLL!<7TrcG>e)Ex3(?HlJA z&e7fy25mJfQOTwaXuO>UwUh9ivB{^P{T_4r+KVkDFi@91=mU-j9NH7U90i~xo3Ck( z{5cW%h+;(YqvzmuTHxCVGu_}V{{Ws{NJl=M8i$otV#qn;))&`iFaPh1dr9~HXQW(U z5T;@lT)QEdYOP>0hqJ&|GFj4HkwRa5MvBQFp?nF`cDVujd=QOL;mwSQ9MN~!%TTNC zSK2rv2lx{ophxhvrX2JPZ^^CyM~LLYTj29erTa1UNhF{KOiiJ^(ZCtPKrIYhjl8r# z)NqTWa5m`v&onnV4x|Tk)xIEHfJ<<4fD3@0G)F;H@^cAtI848&PB;9==R})7REt7) z(cWh5XLbzC60_koRnWkzAG$qyfKq#T0?L-&Uh6E)z?gctL(pPR?&D=_?aCA|X2IR@ zPk&p=htH)O_)7qvD>gyt?C951OpZ--YjR3In6;lQdt&O(`?xzTHK+0aRDDUIxVSzk z4R}(@zDNEkaN9t<0FZ!BI_i^PO;KO}xt6*Hpp=iN(cS007PRAZF>)eaEs&E~JrPmI z)iMAIo=5-w|K)zMXql~YxC;-xH711QpSV$%2QWD0Y;YdpB-orgRz(>Q6jyB#=lQAp z)%^>I+-vG+8ud1_bV(9^@R>SMAU@Ib>Tdr!TLX&94L8nj=#n;^V4aEQv_^~R;S{nQ z>w5;UYDDCZ4?LXdK$QQ+4u3M6pxKC?j)Rf9ge^Px3dWB1W=Gw8LnR1WB@hAWESfiV zk3|2WJUK6C0p~NDI_)(iY0F(_0oRL-ip2b?Bi&7z$RW&1{t}1J20GSqbMgVCrFgq4 z90YXnV*pD<&_6F`qlsr^$a3X5NY;H*O?kSm0uh7QbBJ|an2p`vsl*#1DZYWNcVytvsk_ld+j!DcdUl;bk@`0UI)2+tO!CIZuIyiDthay z50n{gj~H1D<#&D|j~Ye};gD~Es1%q!4|JhbM2`idZk6)e$&~do+`vsl5xX&~#0Zz0 z$B$G6q_EvGTVI9R@MF_2eqU->Rrw732Ffljn9Cv*2{15Ia4)748cfs=G%;}bG$5Q;UN`OF_Qw4xj94Hi=cEb>1g|SbS zbu%UHb)9qB=3}d+rALfwtHlHxdj?EpED%f2)AKVlSi!_trcgj?Qyyye`mG!L&lQ22 zPU{M5H&EJ@SCHCPCA^&OafXad1p`JYIFlAH+AdrMUuVf&0vokEv1$)%w{vN%0**@UY z;vc#6a(+*RC|u{)j1A5FwSoqVMy9m$be;LhoIj@dWY#D5$mM>KcJ_Dck|jWDLqZi4 zFt{_S)aKU#=<*siXX(wZkWbmo^eWm#F5*w+-v$pJ$a=q*S#2Q?+|lvFdNww}Wo93r zFb)GtoinD2<%$(V8q@byUawd7CgJT?E;J>IDKdPzP=X-8`JDgM%>D0+I| zH?U-}S!U3XHDHbCD(i4B+s7|_lWBXiJuq^q&+QpRt;chsm8Nk@6Sc>5Zj79-HdMZ; z41|^7QYC>f-|HZ)4IQz|+^+yfs*3++6#&EifNsB~dLKyHsDFMgIFlKkeTDvU--pk| zCXZ#!QHe6(Rp}!Fa(sHcZ1KY>LI!9qc_4sC3EsTOd+FmkK+SQkO@K{WoqS`eRT!`y zGV^fdH!O(i(UptT4uAYB&1{&z>HvXyp@cBLQIy8lD+P;zW{5<# zasdK&#vQeJ_ZC>!Kf3H5x#H+CWA73tDBg2^$ID(po5m(2}Do zwqICKxb*4TyJi`qCiaQI^A|7*vH)Njn8Qr&czqI4T$)9GV9aNHwnSq?7OVh~NF?96 z5CdXl64S+9debLDp_vh5tUg*VKP$Pco10E5r-#=)X}Wrx47nUtxZq(ufa)IGWE{+# zO?w>B#E0YI)a!%}^VOr4AHdS}OTz3vsK!rwHvGP8h0DhL-4JRB?JnESpm%^>WA}KE zFTH^^H}($3)VS?9ido%?eHx0L!*%^SRwr9rUeg#b7%T}SqFCl8|O>iJkpbTmWXdY zbSEa#^0`gY({pi7B^PSRbGNKzleCU7pj7K&hA=nk=<2$S~X)hU?K@J(Tj2 z(x7U)5#cbmM5cE6N3Ef`^6Jf8K5bvVj{nhy(R?wc5C|Nx%|NVp2K;5{D`wQE#q3(e zNDUWA(Iki|gvfInGS3ve$XmYaOEO!OpiCWmt>sgCE`Y<%Kt1O)1{l7d{B6g94*qgt z#zQrGB8hK%21D>=-aD}GANX8%z?SCm^;*3tT%=>cZ51MB*Qo^ON$)HBTAGW9%nxVV zKdoaYlW`JR(25gR@^^B%!4b=&yn*LiQ*V@)AFKv`L5hTV%9BzqVnL{ z;4ruTSma`gYPT!+^xP%g)5V{r-`S2|$vnkbOB5*fqBr3FavGM~ zv#-`UWy$V?X{?C=U5AiDM)bGGwe$w;e0f5z< zcQ`LV!vKL*qs!n%*o{`N@4ib%j~zo&cyA|mbF(i-Udeo=t+3ep^e~o*Y=^++WmY|xx7&0ggeaw#kOlmlvqT1VB&sj`Bs(({>___#3+G1a~fOb@LOma#U*_ zOAsWYuhn^T~ni;@wg3#F)B?xKucA&@^{RK{lV{*2l2k! zX51W}Zt9#6?m1fd1vWfGz}jA-8Hj)aq+hE1KEk)C)%umU0+AW<__MDkdhW1O{!Nqt zBFj0LMiJE)pfWS`eJ~sGhINnPEfW*}!I4eMbMg6MnW`P|?Dq6DyKz4yb?1ZVK;M@a z!c=-PrCE*M^bQg{4y_TY6!<(~=z9Ap{0)ZWD}Ji(atv z9>eQ&b487g$4n77PCe(50Tugh`v(uInW1F}P)y=ICNNU-3u)7m5YOf|EiN(t4G&`% zlX=i2!zoF+kZ?r~LiMvqm88~u zKWwL)R6|)^O9D2Xay>j3*sG?W4Q08`l5g(URjCe^BoiQ@M?|W1y^-Ym{H&TGT0Q!u z_0yPV28oj~QZEHzFR7~uHgv2zXl}=I3RqPAuDYQE^tm$)mnMNP$jB)Y}f%L#z*Nv-CqhgH6ioM!Jl> zO}?x6IizY>&M0KAzHQk#Uz*uI6oe4OF2~af)KAHcmj?{0W(x+l>qzucC2($NAdQ!< zt~_NG79beZ+LCa;@}9@X`5%`Zu&{y_Noz#WSH=0&L{<3+ouxz17Kd2&nIX$PYO9d| zVuayg2Z$#>KFpI?u;X#nHmhe#Qg_K$(-ofA;Z(T-_7H8@^Nf!3Az5g%{!G88dT}yr z`!lK?W*dy|a#Lq%$&=4HCN^m7bXyL&bMV$f4zah+f%LPQFMV@%ak%WebRd?ecyMF* z1hD@Rg|GPoTN5HR!o0#SIG&{Y@~HPf&#(jv$Jzb3+5r9*CWz0bQaPO^&9qPdVJ!?- z$H>f1U~c`lJ^0T(%P>%f-9O1)p{ zvGJ+8(p~g0Y-pCAmkD1Era#}dx7S8vaDkxZW~25Dy~NNJx8FrCxR9dALzsd?NGq^k zi3vE3>xP~(vyu$-8sM3j*Y{7uV@EdxHOEuCwIZVoh1#1c#KnPVwxvPd#(sGtDTu7^yOS)B!`J9Ouz<&X083C@e! zj5ExsH0mmbL3@E8;eB%PW=nhJ@58r0IWBE)%0EDdJ;!GZK}K}<6)3qu!3lhBES`8M zoNXSxz0(o=)a4t-Gu}>G3^n(60gcp(ox`=UuKgK+_{QN`D-Nh6tbN&S7BD*mCw(k+ z0&oIV|8%r06_?$m@86oIrCp5j#s@Mz&d${hIOnx~u zSbo#KJ>7sy@<&G;C1i>aC$^1P;Wwlvsaz85k`UIH4a_ByLTL?P}+vOchV; zS5MZuoUL{A_8QRAD72!yAZ4UlCy<&o%OPk!c1R!*yq-pnk1?rOol!KLP%cCThwhaV(PTzU9LRf$p`IXwVg1qMo(76Gh|gagy(S;GtWrHgQ&tZB znplNJp?LFGKX}n_CwcaTpBCu6IphCXuIh7dU#?=#@oim)zUO#XVmWKl02qcl-amAD#OM_qpsd7ZCg+DAJ z%>p+^<=WbV(qaR(Hdd$%Z4jZAtDec4vRI0D0hx_H*>Yn2=92Gb6-{KYJAP!~N%qrk z`S%)mf80k9ykuIEZUm+Nkz{OD*EzrJP zRm&u5h}Otub&d^|P@A7Sv1fi$edZ%`)qBkFDmGZbfC(q5DEIW>QxJee=)LQY2;~Z) zO3kCDbZU5srI#V2D|vpzhvMmyhf{4^z9{LmsBaPsSX^!25WsI3aw=fsQ0vRRtWDE- zS9cV1-Z0O@d@m?D;pYBk{GM9EcdoV^ef-3eV-?@Gge z@V9)VEBgAgx-9z^R}>2b+LwV;V%3CH>gFqZaHN>o?JAhx zKlKpOv0OrP)!yaVv%*B)!E0v6-ySkzVSI#U*Qu0DNuooD`I$EK{Eq0%Xui?r@^Fs5 z20T*%q)_QIh)3&s%W{%bYN_MdNb|EEHoZdtQlc`z>56ujy6n$jY>5rCflE)NbxtlH z3Pe{ZUUu$~Iqc*!k+=L}^aw3ucyA-){`lC8^h-9~qTkusPFyO3%g%Supu+(Dwarrj z?At3>6D=4!7&|5tk_x!TR?BUzD|vu+H)NyYegWJ-?ph<+HS5S`eaJiGpsTz_FEdiQ zs!;U;xq7j{MbUazz1USD=H2og{5j%M2c^R_jQ_3=vbqtHORw z5Q7))=y$CM0p^ZSw`X023F=#nT9+N^Sg@!X2i3mZG3#>iB-#ZZNcFlAtqj8sy64dF zd&AnF$MQqOH5i+|dGL>RewV3=Z5QG4gB>nW?etpMi100LskQ~cV?HOi>(AnKaC`9N z_8uXNHxE$o9ll|LaP{pe`F@J$kZcFg)hfA8G8Y|Y&|%)+CQwfX3qBJHD> zw-=g_2q5HMbD+-~UUFC9kyf$axIj7ho82Luou8f#zWWUgNR<4MWfr|$~|c#^RM zarOI{FY|G&TpcfNt-%0S@mrY>tsLM}-Hdxmpy*&J6QBdp6q6^sZftkXq05Ce;qs(1 zD(bCe2Spv1YkOMA#mA$1`{vsZi#a|A(G>BHUTCtJ07%`Ia2h`!?R%575{qjgF52p~%?vEVRxI%;aV3KcIP{2)K>r;t{L}F+4!l z<5Aa5m9@}21#3LemBNFYVdbw16G_H{N%WcyLB-M)Ba6V<#hW!(;?PEc&1e z`3a0Q6<4Tj|HG-ch1+vq7qqovH~F7B@XX)BCOd3$6}MfrIKpi8Zmln*>j(ViJ~ zVvlS78KMF9rUzp@C}$AUD0x_0_68KjG~gb+b0pC8?s#QSSrPuU;aEdgGm|Gt(7 zqFm4i;O|@XV^@iI66P&}`|Z$$&PA6pe^Pn^68sbs7jovYtCgGR+_g#EZ3IP`1@|T# z#K%0|P@2mj&(LM0o# zfKxBxQ)?ZgK&(tu%qv8hMoxm8LML&LlG4c?n0)zJJV`w1s#KzUWmP>KpY2uR4iT{6 zID0eXsXgVJYjzRb`(2s)qbjNTw8%tm&0buRZ)@Vb705Ld(zb7}NWd-z&oXXttO-Xd z_OsFSV3`TAVpd}8Ow^MP9ykL5IL5_);?;(HdJWKLVUQ^$F61=)8{BYo!xy(5)bP-s z>O0%t7tbX&(ZKYm#qs^ySKfUFp`3}nTxAIy7S3z?rv1qf+^%Z~~yi8q78>Q#~#^%khAk(W%h^sx0gtz~dmrELZSx%=d#i_VM@S z_GS9$7mle$h42$QCUEFgQE0>Wz**wWUqX(%bdy$M4ls22#v4MsU3g!DWe=m^#k%-QGEeu9nvvJJ!g!CX7@H6zvbCb(c> zcf}<;3usbe-SDeMZk!!#b5^$wMnH4`Uy8Yr^M&p%bQxCctl@bR5)^G_h_pni&Ac}1 zBpWprZQD)fO!0-44E1^?>$yPVy$I{&@6>FEnlrd-6-L6zN2iaagh(3QsbPD))iW2I zTU@{PI6ky|f6FL@e@1a85P&LseR(As12p9F9+T@F{3RSHN6!Qx^55yKPN508qy#_k zsw-f_@Fgx*oh1allIL%Z>?(+3(V_T%v z-*WKk^;7V*u-Soqba_6>@Anhs0ud(BYf|3)Nk`17YBIsS$1)Sv*J0|$v#osZq;000 zSliOk@OS>ijrb2?%0r1HLv1)xf&rHtRisQt0`71QP6wQpqD>cSbG=nMr=ELQh+Lr7 z?hR=fKc*hXH>Q?HLCpTh=m)M+X`J}OyWz1;L%Bo%(bPz93%^z8km$k#x(H*RD;@2< zz!9aYBRvfC$4+&9?#Q{%D>Bcltz7T|h%@(OxX8ApQxhW^N?-6tu@D=rvg!czmqE(C z%#xoU>4_2MNw)5f3eC)+jr`AKY;NL$=aEGT;@k=>vxa+c*a#zeQg)O>PmX^ zvBf$$?ORXnz5VMgR=VRSDpaxRAh*bQP6Y=h2}|NfYWZK}D{5LoRJ29Flsa;gl6Q>M zSzby|Dam{3|G9hu*MJM+oF2%d-ffVp=j?qb&DW8fbQecqPOS3LM+qQoqwXan@{ajV6i?>+{y89yr!oN#1Z;jPx|Q? zAkas`_2)rG!D8-NALMQyE5x$C;S}16_ZbUk>g7Rx@rsmwH)@^nRNNru<)LcSi;fpp zrY2oa3jlI6eg8uiJ521HACYGy2H&WYdHgH%N>1Z4(3V~@yNnry31)ELf^Y@z4&#O7 z6jZ)wUp4bG5arJg_J>7Bnqd>LN$;c>{Zd#dL0tvMfn{%a(K!Kbl#0R z9R==3*Qgwcer7Ow9d0XZhDhvR97kS6X^dxVepg?=$w?0Y42={ck|RA zv>i{7e5&uG!X6Kdz9kLJIX6ud+JiC|CEdP+zQwEPS1Y(rVjS%+tTfKb>nzz?4yd*r z&L~*_W`4t{%1BAw#BRZa^K>cqOg$g(w+j1xv!?4ud3Nx1c~_N_FHJE;N|p!Adt;Cz zFqgtEZ_NCk)fb2iN7}|aCr=Ql>d>QXG(FQW=n;X8YCP9+qG+@i9fjMmAx;@wD?ujA z??gwp-0Sap9h@W6U2DX_1=+uO5M*vY;AhVEsA1$3A3=qWS)G!?HfsC4>FuCnUUSF1 z+W?HfSTYCm#h5uPJARsUs!3g)(zw7iGP#@i&edyg{x9sOe%X&r?7EgTK>UqLsoRBh zr6X4d`gz{k5h-jw>pT$B#~AhJeQcVGnkdbvZAI`=Mavw|xqc0{fxk^+%Kk=}mp&WL zchVVcWh&vcR|by={d3MuDr~v);)8o1C;bU=yoeiSJGom|>ghrX&7?92RW-g5aLARs zpW@RGk@QmUNQEwOIe|;|{3wcxR7{YK?U-K9*WTfKXMW})oC$X#r*(gS6M7r^v1Q#q zh|;O>c3=oFaf0k8`N8SUGvLcozEj@BYIiIC9E}e^rNq?zC!;q8BWa2Lo~X#NTd!2U zqZ92x`#k!7EFUMZ*;4;eFWYuZ4Qoog(3GRg$3_^&!VwPxdB;uV(lX^l{Vm}-nx+wK&TOaE^x{lg-kbe_Ux+CZ(* z2-fe*LvmrC2eOpPV~RUOzec=*Q=RjCrH(1@Pe0e4S0W@-yAS= znYNzYU73Vc0=z#tsD{|?b2zR)w&Zd{oK6r`GYp5Qu8b_5j9^Fk)8-H~!8Lo)y#!|h=yJeP~ zwb;I@S!8j}8?Hd)7Z;jZQ9+n<{Y=J*f0wez>Gshp{rG{(aW-Yf;f#CF7I~@#s8+8 z>`MA2KaF)nS53XN-KBdVC{}!f%%vobR zLF$^HcoSQD9-mTFh&-CatHg=i<7;5uO5#1CD-`(PYA)v*mbpFkfH)Y?$jL5*&Kbnm&0F5iHYd<9xE*tM zLrnJhwV2krz*Hs=O2S~rqr%4Gwdc_PxByK0Du6N^9qvL&&|HCkQP@-dcA=iQ?l(sq_211;C3yos_(o1<-`)SShKZMQ;PfSEID;%?((giY)9%Zu^MXM?4 zkObySP*wLrwc35A8P^>3%PXW)^%t-atz?E`^w= zGK9UdaAlk=p0KEDYG+<95?_eJTO_B*4Hb;|~p$rPfS^?CLc^fVIFI zISq4iPKNEpUZ>65+sFYU4}dwX4(D-=&*w^PE{!+p+8LU5v`;O zN(5m$D@>l4U8+9If-ykeN6H|y>8srgYc19cYCc~kC>LsFfhlK%X(g~^hZw!{t9>7Z zcYtniyyq@X>;;1_eiX%;=J_MxZl!3(n%{VTwfuNpr0?xiPbvHEDZ(~TSMi(4yC*Zs z8RaHL!|5*0PXn>^lf=^XG-fTwwa+~tE3Eb>{SNB2dfGE?HLdD_6kwms&B=)f9qiTY zz^Hh(q%h+ua`bwrjrn>b&>WtV%GB6#FSLSse?i5rR~*F;j0tde_Nt!65qfGLZ^$6T zI_SK{|4!97Lc_%x!%!)ZKm0DQSI5 zJ5#Lj;>vM@<>k$Jx?oUqHxLt!nwetL+L?0bxhFp#v5~$K4({D)*69!q7WgY!I9-0# zd&)QqcFhf$$xoyD+;8?%QA4!&-qxP%upU@au!D4TBZ&jB+&=LN$`F>{4pDU)c-N&L zd^KV9JpY?VR`sip2dDt6B~>xDo;2b1Yy1MI`IP34)Qjlny?|4oU;9xmF@=?Ds+Gp! zhYSE6pbn(G(LIaWF>smGd0Bu_;;Tdbw7X(c!Yp0PS(!eulf>Mj6^R3ZNgE1MZe!+{ z#h*I4+bG1g7zNZLtdz~b(5u1%OT zKRvxfm1y*w0YO$7s|9*|d37E)vDZ0t(sL`WdiX>i9yP7Gvessn(Dpn#;U_rs&MFmo zx2x6C!6sV&zdh0SolPLem{l!MzOgixv6U&tg$o_y(mnC(UcJXQw|EwaHNzPQukgUe?Ap=d;9A9ZOf!*jVl z8&CCwYWPynMmD@hKcU}~@KZ9}A4Y6_tsJ0X{^S+U!3P6A8!D#1HVCovVJ~7;f?40T zb`BU%p0Q@`3f04T%G@{|u?7JcvBz((mL!hnmpa}2zeq-;8RtP(RxB0G7<+SUKBk&-;J*67qC`mn8M^LYQ{6 zuHcf_r&p72mJZxuf*hn4ay6gqB$gp2p>m>C>Onhw6?XCP9i|4wURf-sY8tlb=c> z9$9CbD$7WM-&k4uTX^~Cf!&70&s?vTLaciv13IIpPmp`0_f(Y&9>2tTi9mfrHKf~p zZ9HW-9T%9JPHOLM$3?j+yPl7AfiDdpr%c-m9s@5wJ&9WY8ipQ1jgJ)bc8>{ji_C?_ z8D(&+cW!dbd^8k?=g{9Nr^bhSuq*cu>+BOXEBN4Dd~JzyKN1^~E5A*NIUK%dJl!*SLj{1Wm<1jj z@VQ@1Qo_Uo8nAM{*o=QoJSR(Soh3EuJfuVguJR!L5#V=P&=z%z$wLYE>5?26Ps$Cl zovWgkU&AxdCrbcERA^oUD@K=l_2pqaBa?-y7#n+ZX;9+5g`VF6+;W#oLbY)%;cbPJ zu%+QX819rFBFPi}6523G&hwj*90wzs-l+~NuWOei+D9i3(v&{&Difvc5X ztPVgn_@?iJm#pr%kvM15 zCy#4#fECtu!RztvGdbPrj1~Z*Cl&{j?Md6s6-ZAr4j51lw@SOMATY7j!)7j1^iLI; zD$XAQc(cOm7foOKMNfB>n9WXqd2Ir{^^6h^b1u_k0iM#BvJ;WDk9N-TB__ z8Q0wkStk8UJF*icoHX_E2La0Wm%ED)w8-d{HzQ#8@wt#fs1w|Ack0(&N+${fP%q!+rpc0nwf+CLNf zLStLel~^ww;LnRa^XaYV&`Fs9Lr4oN$#%nP=dB;)^qN1nH+g?XD;yXt4}(G;s;Cdzc_@kQxAdBmBfA12 zqVYC>%H)CR`+54OE#3f(TZsGVZcEtD%Ac;}K02dQ$OeH}|1TeU-Kl^Gdm`d61Xhjjz-{<)FkW>i?kmv<)o~O%h$_r-!vQpS??!VI zm+%-(Hf)+}%$9uhg|Rys0O~Wh$6Z4+M1GJ&Kp>M*0(GhNJnr{Hc@HlmZ#`)Su)%8_ zPw$*w?N=Flm;7UOZe^qG)u+F^LI0QB1X0mMuknu%t~@r*Hljxqf{TxJ6SufT-Z*X| zvI^N4J7&P{5AHo@od4wK)d{R1ZzL*M<_OZ#^Oy3!^#9YzrA%1)Dh?@l*&35s@iM7! zAr`Lw3QSM|JeFDWRaNUch42J z?U{Sh3k)6bN;>-(7!;g49WyGOKfjL2ZG(Z?f8

      diff --git a/docs/index.html b/docs/index.html index 9c2a847..879feb9 100644 --- a/docs/index.html +++ b/docs/index.html @@ -33,7 +33,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -59,6 +59,9 @@ Tutorial
    + +
  • + Changelog
      • @@ -88,9 +91,9 @@

      Installation

      Install the development version of metacal from from GitHub,

      -
      -# install.packages("devtools")
-devtools::install_github("mikemc/metacal")
      +
      +# install.packages("devtools")
+devtools::install_github("mikemc/metacal")

      diff --git a/docs/news/index.html b/docs/news/index.html new file mode 100644 index 0000000..17f20d4 --- /dev/null +++ b/docs/news/index.html @@ -0,0 +1,201 @@ + + + + + + + + +Changelog • metacal + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
      +
      + + + + +
      + +
      +
      +
      +

      Changelog

      + Source: NEWS.md +
      + +
      +

      +metacal 0.2.0

      +
      +

      +New features

      +
      +

      +New estimation and calibration functions

      +

      estimate_bias() and calibrate() provide easy-to-use high-level interfaces to the original metacal bias-estimation and calibration method. Their use is illustrated in the new tutorial.

      +
      +
      +

      +New utility functions

      +
        +

      • pairwise_ratios() allows computing ratios between pairs of taxa and/or samples.

        • +

      • perturb() applies a compositional perturbation to all observations in an abundance matrix (or phyloseq object).

        • +
      +
      +
      +

      +Support for phyloseq objects

      +

      The new functions estimate_bias(), perturb(), calibrate(), and pairwise_ratios() all work with objects from the phyloseq package as well as plain matrices. Phyloseq is now a required dependency, though may be made optional in the future.

      +
      +
      +

      +New tutorial

      +

      The new tutorial demonstrates the new estimation and calibration functions on a new dataset from Leopold and Busby (2020).

      +
      +
      +
      +

      +Minor fixes

      +
        +
      • Fixed failure of coocurrence_matrix() when names were missing (#5).
        • +
      +
      +
      +
      +

      +metacal 0.1.0

      +

      Direct implementation of the methods described in McLaren MR, Willis AD, Callahan BJ (2019) and used for the analysis of that paper.

      +
      +
      + + + +
      + + +
      +
      +

      Developed by Michael McLaren.

      +
      + +
      +

      Site built with pkgdown 1.6.1.

      +
      + +
      +
      + + + + + + + + diff --git a/docs/pkgdown.yml b/docs/pkgdown.yml index 0e2258a..73b6b35 100644 --- a/docs/pkgdown.yml +++ b/docs/pkgdown.yml @@ -1,7 +1,7 @@ -pandoc: 2.10.1 +pandoc: 2.11.2 pkgdown: 1.6.1 pkgdown_sha: ~ articles: tutorial: tutorial.html -last_built: 2020-10-21T13:54Z +last_built: 2020-12-20T23:13Z diff --git a/docs/reference/anorm.html b/docs/reference/anorm.html index 653ea89..16e1b79 100644 --- a/docs/reference/anorm.html +++ b/docs/reference/anorm.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0

      @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/as_matrix.html b/docs/reference/as_matrix.html index bc60192..ad18207 100644 --- a/docs/reference/as_matrix.html +++ b/docs/reference/as_matrix.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/bootrep_center.html b/docs/reference/bootrep_center.html index ae2ac43..604fdf9 100644 --- a/docs/reference/bootrep_center.html +++ b/docs/reference/bootrep_center.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/build_matrix.html b/docs/reference/build_matrix.html index 49dc4f5..35a3625 100644 --- a/docs/reference/build_matrix.html +++ b/docs/reference/build_matrix.html @@ -73,7 +73,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -99,6 +99,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/calibrate.html b/docs/reference/calibrate.html index 1234e48..724efb6 100644 --- a/docs/reference/calibrate.html +++ b/docs/reference/calibrate.html @@ -75,7 +75,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -101,6 +101,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/center.html b/docs/reference/center.html index 92694ba..cd9ff6d 100644 --- a/docs/reference/center.html +++ b/docs/reference/center.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/center_elts.html b/docs/reference/center_elts.html index 9760692..656f5cd 100644 --- a/docs/reference/center_elts.html +++ b/docs/reference/center_elts.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/close_elts.html b/docs/reference/close_elts.html index 184509c..57ab569 100644 --- a/docs/reference/close_elts.html +++ b/docs/reference/close_elts.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/clr.html b/docs/reference/clr.html index ed0fe6d..7950e61 100644 --- a/docs/reference/clr.html +++ b/docs/reference/clr.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/compute_ratios.html b/docs/reference/compute_ratios.html index 64cedf6..06577fd 100644 --- a/docs/reference/compute_ratios.html +++ b/docs/reference/compute_ratios.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/cooccurrence.html b/docs/reference/cooccurrence.html index 287e25f..06f119b 100644 --- a/docs/reference/cooccurrence.html +++ b/docs/reference/cooccurrence.html @@ -73,7 +73,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -99,6 +99,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/corner.html b/docs/reference/corner.html index 12ca1ce..23f2d3e 100644 --- a/docs/reference/corner.html +++ b/docs/reference/corner.html @@ -77,7 +77,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -103,6 +103,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/estimate_bias.html b/docs/reference/estimate_bias.html index cb9e111..5891110 100644 --- a/docs/reference/estimate_bias.html +++ b/docs/reference/estimate_bias.html @@ -73,7 +73,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -99,6 +99,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/gm.html b/docs/reference/gm.html index 3ea7d3d..c95d655 100644 --- a/docs/reference/gm.html +++ b/docs/reference/gm.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/gm_abs.html b/docs/reference/gm_abs.html index 16e0218..124777c 100644 --- a/docs/reference/gm_abs.html +++ b/docs/reference/gm_abs.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/gm_mean.html b/docs/reference/gm_mean.html index d7647b3..885c4c0 100644 --- a/docs/reference/gm_mean.html +++ b/docs/reference/gm_mean.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/gm_range.html b/docs/reference/gm_range.html index 777e7bd..6c388d8 100644 --- a/docs/reference/gm_range.html +++ b/docs/reference/gm_range.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/gm_sd.html b/docs/reference/gm_sd.html index d2caafa..7063b59 100644 --- a/docs/reference/gm_sd.html +++ b/docs/reference/gm_sd.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/import_phyloseq.html b/docs/reference/import_phyloseq.html index 49b1777..f02f3ba 100644 --- a/docs/reference/import_phyloseq.html +++ b/docs/reference/import_phyloseq.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/index.html b/docs/reference/index.html index 9a00fe1..c90c6a4 100644 --- a/docs/reference/index.html +++ b/docs/reference/index.html @@ -71,7 +71,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -97,6 +97,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/log_center_proj.html b/docs/reference/log_center_proj.html index f76c179..413a574 100644 --- a/docs/reference/log_center_proj.html +++ b/docs/reference/log_center_proj.html @@ -73,7 +73,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -99,6 +99,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/log_center_rss.html b/docs/reference/log_center_rss.html index c2fbf4e..e47ae2b 100644 --- a/docs/reference/log_center_rss.html +++ b/docs/reference/log_center_rss.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/logit.html b/docs/reference/logit.html index 4847132..0a0e160 100644 --- a/docs/reference/logit.html +++ b/docs/reference/logit.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/mutate_by.html b/docs/reference/mutate_by.html index a15ea60..3366687 100644 --- a/docs/reference/mutate_by.html +++ b/docs/reference/mutate_by.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/odds.html b/docs/reference/odds.html index 2366d88..88d2259 100644 --- a/docs/reference/odds.html +++ b/docs/reference/odds.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/pairwise_ratios.html b/docs/reference/pairwise_ratios.html index 23b68e1..b9318a8 100644 --- a/docs/reference/pairwise_ratios.html +++ b/docs/reference/pairwise_ratios.html @@ -73,7 +73,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -99,6 +99,9 @@ Tutorial
    + +
  • + Changelog
      • diff --git a/docs/reference/perturb.html b/docs/reference/perturb.html index 806a642..3a42d37 100644 --- a/docs/reference/perturb.html +++ b/docs/reference/perturb.html @@ -73,7 +73,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -99,6 +99,9 @@ Tutorial
    + +
  • + Changelog
      • @@ -140,7 +143,10 @@

      Compositionally perturb a relative-abundance matrix

      perturb(x, y, norm = "close") # S3 method for phyloseq -perturb(x, y, norm = "close") +perturb(x, y, norm = "close") + +# S3 method for mc_bias_fit +perturb(x, y)

      Arguments

      diff --git a/docs/reference/proj_mat.html b/docs/reference/proj_mat.html index 900cfb9..e0fedeb 100644 --- a/docs/reference/proj_mat.html +++ b/docs/reference/proj_mat.html @@ -73,7 +73,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -99,6 +99,9 @@ Tutorial + +
    • + Changelog
        • diff --git a/docs/reference/xydist.html b/docs/reference/xydist.html index 3647a71..2b95787 100644 --- a/docs/reference/xydist.html +++ b/docs/reference/xydist.html @@ -72,7 +72,7 @@ metacal - 0.1.0.9011 + 0.2.0 @@ -98,6 +98,9 @@ Tutorial
      + +
    • + Changelog