StandardHypoTestInvDemo.C

// Modifications: added a name argument to the method, so that graphs can be saved with a name.
// -Max Horton
// Maxwell.christian.horton@gmail.com



/* -*- mode: c++ -*- */
// Standard tutorial macro for performing an inverted  hypothesis test for computing an interval
//
// This macro will perform a scan of the p-values for computing the interval or limit
//
//Author:  L. Moneta
//
// Usage: 
//
// root>.L StandardHypoTestInvDemo.C
// root> StandardHypoTestInvDemo("fileName","workspace name","S+B modelconfig name","B model name","data set name",calculator type, test statistic type, use CLS, 
//                                number of points, xmin, xmax, number of toys, use number counting)
//
//
// type = 0 Freq calculator 
// type = 1 Hybrid calculator
// type = 2 Asymptotic calculator  
// type = 3 Asymptotic calculator using nominal Asimov data sets (not using fitted parameter values but nominal ones)
//
// testStatType = 0 LEP
//              = 1 Tevatron 
//              = 2 Profile Likelihood two sided
//              = 3 Profile Likelihood one sided (i.e. = 0 if mu < mu_hat)
//              = 4 Profile Likelihood signed ( pll = -pll if mu < mu_hat) 
//              = 5 Max Likelihood Estimate as test statistic
//              = 6 Number of observed event as test statistic
//
 

#include "TFile.h"
#include "RooWorkspace.h"
#include "RooAbsPdf.h"
#include "RooRealVar.h"
#include "RooDataSet.h"
#include "RooStats/ModelConfig.h"
#include "RooRandom.h"
#include "TGraphErrors.h"
#include "TGraphAsymmErrors.h"



#include "TCanvas.h"
#include "TLine.h"
#include "TROOT.h"

#include "RooStats/AsymptoticCalculator.h"
#include "RooStats/HybridCalculator.h"
#include "RooStats/FrequentistCalculator.h"
#include "RooStats/ToyMCSampler.h"
#include "RooStats/HypoTestPlot.h"

#include "RooStats/NumEventsTestStat.h"
#include "RooStats/ProfileLikelihoodTestStat.h"
#include "RooStats/SimpleLikelihoodRatioTestStat.h"
#include "RooStats/RatioOfProfiledLikelihoodsTestStat.h"
#include "RooStats/MaxLikelihoodEstimateTestStat.h"
#include "RooStats/NumEventsTestStat.h"

#include "RooStats/HypoTestInverter.h"
#include "RooStats/HypoTestInverterResult.h"
#include "RooStats/HypoTestInverterPlot.h"

using namespace RooFit;
using namespace RooStats;


bool plotHypoTestResult = true;          // plot test statistic result at each point
bool writeResult = true;                 // write HypoTestInverterResult in a file 
TString resultFileName;                  // file with results (by default is built automatically using the workspace input file name)
bool optimize = true;                    // optmize evaluation of test statistic 
bool useVectorStore = true;              // convert data to use new roofit data store 
bool generateBinned = false;             // generate binned data sets 
bool noSystematics = false;              // force all systematics to be off (i.e. set all nuisance parameters as constat
                                         // to their nominal values)
double nToysRatio = 2;                   // ratio Ntoys S+b/ntoysB
double maxPOI = -1;                      // max value used of POI (in case of auto scan) 
bool useProof = false;                    // use Proof Light when using toys (for freq or hybrid)
int nworkers = 4;                        // number of worker for Proof
bool rebuild = false;                    // re-do extra toys for computing expected limits and rebuild test stat
                                         // distributions (N.B this requires much more CPU (factor is equivalent to nToyToRebuild)
int nToyToRebuild = 100;                 // number of toys used to rebuild 
int initialFit = -1;                     // do a first  fit to the model (-1 : default, 0 skip fit, 1 do always fit) 
int randomSeed = -1;                     // random seed (if = -1: use default value, if = 0 always random )
                                         // NOTE: Proof uses automatically a random seed

std::string massValue = "";              // extra string to tag output file of result 
std::string  minimizerType = "";                  // minimizer type (default is what is in ROOT::Math::MinimizerOptions::DefaultMinimizerType()
int   printLevel = 0;                    // print level for debugging PL test statistics and calculators  



// internal class to run the inverter and more

namespace RooStats { 

   class HypoTestInvTool{

   public:
      HypoTestInvTool();
      ~HypoTestInvTool(){};

      HypoTestInverterResult * 
      RunInverter(RooWorkspace * w, 
                  const char * modelSBName, const char * modelBName, 
                  const char * dataName,
                  int type,  int testStatType, 
                  bool useCLs, 
                  int npoints, double poimin, double poimax, int ntoys, 
                  bool useNumberCounting = false, 
                  const char * nuisPriorName = 0);



      void
      AnalyzeResult( HypoTestInverterResult * r,
                     int calculatorType,
                     int testStatType, 
                     bool useCLs,  
                     int npoints,
                     const char * fileNameBase = 0 );

      void SetParameter(const char * name, const char * value);
      void SetParameter(const char * name, bool value);
      void SetParameter(const char * name, int value);
      void SetParameter(const char * name, double value);

   private:

      bool mPlotHypoTestResult;
      bool mWriteResult;
      bool mOptimize;
      bool mUseVectorStore;
      bool mGenerateBinned;
      bool mUseProof;
      bool mRebuild;
      int     mNWorkers;
      int     mNToyToRebuild;
      int     mPrintLevel;
      int     mInitialFit; 
      int     mRandomSeed; 
      double  mNToysRatio;
      double  mMaxPoi;
      std::string mMassValue;
      std::string mMinimizerType;                  // minimizer type (default is what is in ROOT::Math::MinimizerOptions::DefaultMinimizerType()
      TString     mResultFileName; 
   };

} // end namespace RooStats

RooStats::HypoTestInvTool::HypoTestInvTool() : mPlotHypoTestResult(true),
                                               mWriteResult(false),
                                               mOptimize(true),
                                               mUseVectorStore(true),
                                               mGenerateBinned(false),
                                               mUseProof(false),
                                               mRebuild(false),
                                               mNWorkers(4),
                                               mNToyToRebuild(100),
                                               mPrintLevel(0),
                                               mInitialFit(-1),
                                               mRandomSeed(-1),
                                               mNToysRatio(2),
                                               mMaxPoi(-1),
                                               mMassValue(""),
                                               mMinimizerType(""),
                                               mResultFileName() {
}



void
RooStats::HypoTestInvTool::SetParameter(const char * name, bool value){
   //
   // set boolean parameters
   //

   std::string s_name(name);

   if (s_name.find("PlotHypoTestResult") != std::string::npos) mPlotHypoTestResult = value;
   if (s_name.find("WriteResult") != std::string::npos) mWriteResult = value;
   if (s_name.find("Optimize") != std::string::npos) mOptimize = value;
   if (s_name.find("UseVectorStore") != std::string::npos) mUseVectorStore = value;
   if (s_name.find("GenerateBinned") != std::string::npos) mGenerateBinned = value;
   if (s_name.find("UseProof") != std::string::npos) mUseProof = value;
   if (s_name.find("Rebuild") != std::string::npos) mRebuild = value;

   return;
}



void
RooStats::HypoTestInvTool::SetParameter(const char * name, int value){
   //
   // set integer parameters
   //

   std::string s_name(name);

   if (s_name.find("NWorkers") != std::string::npos) mNWorkers = value;
   if (s_name.find("NToyToRebuild") != std::string::npos) mNToyToRebuild = value;
   if (s_name.find("PrintLevel") != std::string::npos) mPrintLevel = value;
   if (s_name.find("InitialFit") != std::string::npos) mInitialFit = value;
   if (s_name.find("RandomSeed") != std::string::npos) mRandomSeed = value;

   return;
}



void
RooStats::HypoTestInvTool::SetParameter(const char * name, double value){
   //
   // set double precision parameters
   //

   std::string s_name(name);

   if (s_name.find("NToysRatio") != std::string::npos) mNToysRatio = value;
   if (s_name.find("MaxPOI") != std::string::npos) mMaxPoi = value;

   return;
}



void
RooStats::HypoTestInvTool::SetParameter(const char * name, const char * value){
   //
   // set string parameters
   //

   std::string s_name(name);

   if (s_name.find("MassValue") != std::string::npos) mMassValue.assign(value);
   if (s_name.find("MinimizerType") != std::string::npos) mMinimizerType.assign(value);
   if (s_name.find("ResultFileName") != std::string::npos) mResultFileName = value;

   return;
}


char *output_name_cls;
char *output_name_bells;





void 
StandardHypoTestInvDemo(const char * infile = "ws_twobin.root",
                        const char * wsName = "newws",
                        const char * modelSBName = "SbModel",
                        const char * modelBName = "BModel",
                        const char * dataName = "data",                 
                        int calculatorType = 0,
                        int testStatType = 2,//was 0 
                        bool useCLs = true ,  
                        int npoints = 4,   
                        double poimin = 0,  
                        double poimax = 1000, 
                        int ntoys=1000,
                        bool useNumberCounting = false,
                        const char * nuisPriorName = 0,
                        char *cls_name = "cls.png",
                        char *bells_name = "bells.png"){


  output_name_cls = cls_name;
  output_name_bells = bells_name;



/*

  Other Parameter to pass in tutorial
  apart from standard for filename, ws, modelconfig and data

  type = 0 Freq calculator 
  type = 1 Hybrid calculator
  type = 2 Asymptotic calculator  
  type = 3 Asymptotic calculator using nominal Asimov data sets (not using fitted parameter values but nominal ones)

  testStatType = 0 LEP
  = 1 Tevatron 
  = 2 Profile Likelihood
  = 3 Profile Likelihood one sided (i.e. = 0 if mu < mu_hat)
  = 4 Profiel Likelihood signed ( pll = -pll if mu < mu_hat) 
  = 5 Max Likelihood Estimate as test statistic
  = 6 Number of observed event as test statistic

  useCLs          scan for CLs (otherwise for CLs+b)    

  npoints:        number of points to scan , for autoscan set npoints = -1 

  poimin,poimax:  min/max value to scan in case of fixed scans 
  (if min >  max, try to find automatically)                           

  ntoys:         number of toys to use 

  useNumberCounting:  set to true when using number counting events 

  nuisPriorName:   name of prior for the nnuisance. This is often expressed as constraint term in the global model
  It is needed only when using the HybridCalculator (type=1)
  If not given by default the prior pdf from ModelConfig is used. 

  extra options are available as global paramwters of the macro. They major ones are: 

  plotHypoTestResult   plot result of tests at each point (TS distributions) (defauly is true)
  useProof             use Proof   (default is true) 
  writeResult          write result of scan (default is true)
  rebuild              rebuild scan for expected limits (require extra toys) (default is false)
  generateBinned       generate binned data sets for toys (default is false) - be careful not to activate with 
  a too large (>=3) number of observables 
  nToyRatio            ratio of S+B/B toys (default is 2)
    

*/

  
  
   TString fileName(infile);
   if (fileName.IsNull()) { 
      fileName = "results/example_combined_GaussExample_model.root";
      std::cout << "Use standard file generated with HistFactory : " << fileName << std::endl;
   }
  
   // open file and check if input file exists
   TFile * file = TFile::Open(fileName); 
  
   // if input file was specified but not found, quit
   if(!file && !TString(infile).IsNull()){
      cout <<"file " << fileName << " not found" << endl;
      return;
   } 
  
   // if default file not found, try to create it
   if(!file ){
      // Normally this would be run on the command line
      cout <<"will run standard hist2workspace example"<<endl;
      gROOT->ProcessLine(".! prepareHistFactory .");
      gROOT->ProcessLine(".! hist2workspace config/example.xml");
      cout <<"\n\n---------------------"<<endl;
      cout <<"Done creating example input"<<endl;
      cout <<"---------------------\n\n"<<endl;
    
      // now try to access the file again
      file = TFile::Open(fileName);
    
   }
  
   if(!file){
      // if it is still not there, then we can't continue
      cout << "Not able to run hist2workspace to create example input" <<endl;
      return;
   }
  


   HypoTestInvTool calc;

   // set parameters
   calc.SetParameter("PlotHypoTestResult", plotHypoTestResult);
   calc.SetParameter("WriteResult", writeResult);
   calc.SetParameter("Optimize", optimize);
   calc.SetParameter("UseVectorStore", useVectorStore);
   calc.SetParameter("GenerateBinned", generateBinned);
   calc.SetParameter("NToysRatio", nToysRatio);
   calc.SetParameter("MaxPOI", maxPOI);
   calc.SetParameter("UseProof", useProof);
   calc.SetParameter("NWorkers", nworkers);
   calc.SetParameter("Rebuild", rebuild);
   calc.SetParameter("NToyToRebuild", nToyToRebuild);
   calc.SetParameter("MassValue", massValue.c_str());
   calc.SetParameter("MinimizerType", minimizerType.c_str());
   calc.SetParameter("PrintLevel", printLevel);
   calc.SetParameter("InitialFit",initialFit);
   calc.SetParameter("ResultFileName",resultFileName);
   calc.SetParameter("RandomSeed",randomSeed);


   RooWorkspace * w = dynamic_cast<RooWorkspace*>( file->Get(wsName) );
   HypoTestInverterResult * r = 0;  
   std::cout << w << "\t" << fileName << std::endl;
   if (w != NULL) {
      r = calc.RunInverter(w, modelSBName, modelBName,
                           dataName, calculatorType, testStatType, useCLs,
                           npoints, poimin, poimax,  
                           ntoys, useNumberCounting, nuisPriorName );    
      if (!r) { 
         std::cerr << "Error running the HypoTestInverter - Exit " << std::endl;
         return;          
      }
   }
   else { 
      // case workspace is not present look for the inverter result
      std::cout << "Reading an HypoTestInverterResult with name " << wsName << " from file " << fileName << std::endl;
      r = dynamic_cast<HypoTestInverterResult*>( file->Get(wsName) ); //
      if (!r) { 
         std::cerr << "File " << fileName << " does not contain a workspace or an HypoTestInverterResult - Exit " 
                   << std::endl;
         file->ls();
         return; 
      }
   }		
  
   calc.AnalyzeResult( r, calculatorType, testStatType, useCLs, npoints, infile );
  
   return;
}



void
RooStats::HypoTestInvTool::AnalyzeResult( HypoTestInverterResult * r,
                                          int calculatorType,
                                          int testStatType, 
                                          bool useCLs,  
                                          int npoints,
                                          const char * fileNameBase ){

   // analyze result produced by the inverter, optionally save it in a file 
   
  
   double lowerLimit = 0;
   double llError = 0;
#if defined ROOT_SVN_VERSION &&  ROOT_SVN_VERSION >= 44126
   if (r->IsTwoSided()) {
      lowerLimit = r->LowerLimit();
      llError = r->LowerLimitEstimatedError();
   }
#else
   lowerLimit = r->LowerLimit();
   llError = r->LowerLimitEstimatedError();
#endif

   double upperLimit = r->UpperLimit();
   double ulError = r->UpperLimitEstimatedError();

   //std::cout << "DEBUG : [ " << lowerLimit << " , " << upperLimit << "  ] " << std::endl;
      
   if (lowerLimit < upperLimit*(1.- 1.E-4) && lowerLimit != 0) 
      std::cout << "The computed lower limit is: " << lowerLimit << " +/- " << llError << std::endl;
   std::cout << "The computed upper limit is: " << upperLimit << " +/- " << ulError << std::endl;
  

   // compute expected limit
   std::cout << "Expected upper limits, using the B (alternate) model : " << std::endl;
   std::cout << " expected limit (median) " << r->GetExpectedUpperLimit(0) << std::endl;
   std::cout << " expected limit (-1 sig) " << r->GetExpectedUpperLimit(-1) << std::endl;
   std::cout << " expected limit (+1 sig) " << r->GetExpectedUpperLimit(1) << std::endl;
   std::cout << " expected limit (-2 sig) " << r->GetExpectedUpperLimit(-2) << std::endl;
   std::cout << " expected limit (+2 sig) " << r->GetExpectedUpperLimit(2) << std::endl;
  
  
   // write result in a file 
   if (r != NULL && mWriteResult) {
    
      // write to a file the results
      const char *  calcType = (calculatorType == 0) ? "Freq" : (calculatorType == 1) ? "Hybr" : "Asym";
      const char *  limitType = (useCLs) ? "CLs" : "Cls+b";
      const char * scanType = (npoints < 0) ? "auto" : "grid";
      if (mResultFileName.IsNull()) {
         mResultFileName = TString::Format("%s_%s_%s_ts%d_",calcType,limitType,scanType,testStatType);      
         //strip the / from the filename
         if (mMassValue.size()>0) {
            mResultFileName += mMassValue.c_str();
            mResultFileName += "_";
         }
    
         TString name = fileNameBase; 
         name.Replace(0, name.Last('/')+1, "");
         mResultFileName += name;
      }

      TFile * fileOut = new TFile(mResultFileName,"RECREATE");
      r->Write();
      fileOut->Close();                                                                     
   }   
  
  
   // plot the result ( p values vs scan points) 
   std::string typeName = "";
   if (calculatorType == 0 )
      typeName = "Frequentist";
   if (calculatorType == 1 )
      typeName = "Hybrid";   
   else if (calculatorType == 2 || calculatorType == 3) { 
      typeName = "Asymptotic";
      mPlotHypoTestResult = false; 
   }
  
   const char * resultName = r->GetName();
   TString plotTitle = TString::Format("%s CL Scan for workspace %s",typeName.c_str(),resultName);
   HypoTestInverterPlot *plot = new HypoTestInverterPlot("HTI_Result_Plot",plotTitle,r);

   // plot in a new canvas with style
   TString c1Name = TString::Format("%s_Scan",typeName.c_str());
   TCanvas * c1 = new TCanvas(c1Name); 
   c1->SetLogy(false);

   plot->Draw("CLb 2CL");  // plot all and Clb

   // if (useCLs) 
   //    plot->Draw("CLb 2CL");  // plot all and Clb
   // else 
   //    plot->Draw("");  // plot all and Clb
  
   const int nEntries = r->ArraySize();
  
   // plot test statistics distributions for the two hypothesis 
   if (mPlotHypoTestResult) { 
      TCanvas * c2 = new TCanvas();
      if (nEntries > 1) { 
         int ny = TMath::CeilNint( sqrt(nEntries) );
         int nx = TMath::CeilNint(double(nEntries)/ny);
         c2->Divide(nx,ny);
      }
      for (int i=0; i<nEntries; i++) {
         if (nEntries > 1) c2->cd(i+1);
         SamplingDistPlot * pl = plot->MakeTestStatPlot(i);
         pl->SetLogYaxis(true);
         pl->Draw();
      }
   }

  c1->Print(output_name_bells);
  c2->Print(output_name_cls);
}



// internal routine to run the inverter
HypoTestInverterResult *
RooStats::HypoTestInvTool::RunInverter(RooWorkspace * w,
                                       const char * modelSBName, const char * modelBName, 
                                       const char * dataName, int type,  int testStatType, 
                                       bool useCLs, int npoints, double poimin, double poimax, 
                                       int ntoys,
                                       bool useNumberCounting,
                                       const char * nuisPriorName ){

   std::cout << "Running HypoTestInverter on the workspace " << w->GetName() << std::endl;
  
   w->Print();
  
  
   RooAbsData * data = w->data(dataName); 
   if (!data) { 
      Error("StandardHypoTestDemo","Not existing data %s",dataName);
      return 0;
   }
   else 
      std::cout << "Using data set " << dataName << std::endl;
  
   if (mUseVectorStore) { 
      RooAbsData::defaultStorageType = RooAbsData::Vector;
      data->convertToVectorStore() ;
   }
  
  
   // get models from WS
   // get the modelConfig out of the file
   ModelConfig* bModel = (ModelConfig*) w->obj(modelBName);
   ModelConfig* sbModel = (ModelConfig*) w->obj(modelSBName);
  
   if (!sbModel) {
      Error("StandardHypoTestDemo","Not existing ModelConfig %s",modelSBName);
      return 0;
   }
   // check the model 
   if (!sbModel->GetPdf()) { 
      Error("StandardHypoTestDemo","Model %s has no pdf ",modelSBName);
      return 0;
   }
   if (!sbModel->GetParametersOfInterest()) {
      Error("StandardHypoTestDemo","Model %s has no poi ",modelSBName);
      return 0;
   }
   if (!sbModel->GetObservables()) {
      Error("StandardHypoTestInvDemo","Model %s has no observables ",modelSBName);
      return 0;
   }
   if (!sbModel->GetSnapshot() ) { 
      Info("StandardHypoTestInvDemo","Model %s has no snapshot  - make one using model poi",modelSBName);
      sbModel->SetSnapshot( *sbModel->GetParametersOfInterest() );
   }
  
   // case of no systematics
   // remove nuisance parameters from model
   if (noSystematics) { 
      const RooArgSet * nuisPar = sbModel->GetNuisanceParameters();
      if (nuisPar && nuisPar->getSize() > 0) { 
         std::cout << "StandardHypoTestInvDemo" << "  -  Switch off all systematics by setting them constant to their initial values" << std::endl;
         RooStats::SetAllConstant(*nuisPar);
      }
      if (bModel) { 
         const RooArgSet * bnuisPar = bModel->GetNuisanceParameters();
         if (bnuisPar) 
            RooStats::SetAllConstant(*bnuisPar);
      }
   }
  
   if (!bModel || bModel == sbModel) {
      Info("StandardHypoTestInvDemo","The background model %s does not exist",modelBName);
      Info("StandardHypoTestInvDemo","Copy it from ModelConfig %s and set POI to zero",modelSBName);
      bModel = (ModelConfig*) sbModel->Clone();
      bModel->SetName(TString(modelSBName)+TString("_with_poi_0"));      
      RooRealVar * var = dynamic_cast<RooRealVar*>(bModel->GetParametersOfInterest()->first());
      if (!var) return 0;
      double oldval = var->getVal();
      var->setVal(0);
      bModel->SetSnapshot( RooArgSet(*var)  );
      var->setVal(oldval);
   }
   else { 
      if (!bModel->GetSnapshot() ) { 
         Info("StandardHypoTestInvDemo","Model %s has no snapshot  - make one using model poi and 0 values ",modelBName);
         RooRealVar * var = dynamic_cast<RooRealVar*>(bModel->GetParametersOfInterest()->first());
         if (var) { 
            double oldval = var->getVal();
            var->setVal(0);
            bModel->SetSnapshot( RooArgSet(*var)  );
            var->setVal(oldval);
         }
         else { 
            Error("StandardHypoTestInvDemo","Model %s has no valid poi",modelBName);
            return 0;
         }         
      }
   }

   // check model  has global observables when there are nuisance pdf
   // for the hybrid case the globobs are not needed
   if (type != 1 ) { 
      bool hasNuisParam = (sbModel->GetNuisanceParameters() && sbModel->GetNuisanceParameters()->getSize() > 0);
      bool hasGlobalObs = (sbModel->GetGlobalObservables() && sbModel->GetGlobalObservables()->getSize() > 0);
      if (hasNuisParam && !hasGlobalObs ) {  
         // try to see if model has nuisance parameters first 
         RooAbsPdf * constrPdf = RooStats::MakeNuisancePdf(*sbModel,"nuisanceConstraintPdf_sbmodel");
         if (constrPdf) { 
            Warning("StandardHypoTestInvDemo","Model %s has nuisance parameters but no global observables associated",sbModel->GetName());
            Warning("StandardHypoTestInvDemo","\tThe effect of the nuisance parameters will not be treated correctly ");
         }
      }
   }


  
   // run first a data fit 
  
   const RooArgSet * poiSet = sbModel->GetParametersOfInterest();
   RooRealVar *poi = (RooRealVar*)poiSet->first();
  
   std::cout << "StandardHypoTestInvDemo : POI initial value:   " << poi->GetName() << " = " << poi->getVal()   << std::endl;  
  
   // fit the data first (need to use constraint )
   TStopwatch tw; 

   bool doFit = initialFit;
   if (testStatType == 0 && initialFit == -1) doFit = false;  // case of LEP test statistic
   if (type == 3  && initialFit == -1) doFit = false;         // case of Asymptoticcalculator with nominal Asimov
   double poihat = 0;

   if (minimizerType.size()==0) minimizerType = ROOT::Math::MinimizerOptions::DefaultMinimizerType();
   else 
      ROOT::Math::MinimizerOptions::SetDefaultMinimizer(minimizerType.c_str());
    
   Info("StandardHypoTestInvDemo","Using %s as minimizer for computing the test statistic",
        ROOT::Math::MinimizerOptions::DefaultMinimizerType().c_str() );
   
   if (doFit)  { 

      // do the fit : By doing a fit the POI snapshot (for S+B)  is set to the fit value
      // and the nuisance parameters nominal values will be set to the fit value. 
      // This is relevant when using LEP test statistics

      Info( "StandardHypoTestInvDemo"," Doing a first fit to the observed data ");
      RooArgSet constrainParams;
      if (sbModel->GetNuisanceParameters() ) constrainParams.add(*sbModel->GetNuisanceParameters());
      RooStats::RemoveConstantParameters(&constrainParams);
      tw.Start(); 
      RooFitResult * fitres = sbModel->GetPdf()->fitTo(*data,InitialHesse(false), Hesse(false),
                                                       Minimizer(minimizerType.c_str(),"Migrad"), Strategy(0), PrintLevel(mPrintLevel), Constrain(constrainParams), Save(true) );
      if (fitres->status() != 0) { 
         Warning("StandardHypoTestInvDemo","Fit to the model failed - try with strategy 1 and perform first an Hesse computation");
         fitres = sbModel->GetPdf()->fitTo(*data,InitialHesse(true), Hesse(false),Minimizer(minimizerType.c_str(),"Migrad"), Strategy(1), PrintLevel(mPrintLevel+1), Constrain(constrainParams), Save(true) );
      }
      if (fitres->status() != 0) 
         Warning("StandardHypoTestInvDemo"," Fit still failed - continue anyway.....");
  
  
      poihat  = poi->getVal();
      std::cout << "StandardHypoTestInvDemo - Best Fit value : " << poi->GetName() << " = "  
                << poihat << " +/- " << poi->getError() << std::endl;
      std::cout << "Time for fitting : "; tw.Print(); 
  
      //save best fit value in the poi snapshot 
      sbModel->SetSnapshot(*sbModel->GetParametersOfInterest());
      std::cout << "StandardHypoTestInvo: snapshot of S+B Model " << sbModel->GetName() 
                << " is set to the best fit value" << std::endl;
  
   }

   // print a message in case of LEP test statistics because it affects result by doing or not doing a fit 
   if (testStatType == 0) {
      if (!doFit) 
         Info("StandardHypoTestInvDemo","Using LEP test statistic - an initial fit is not done and the TS will use the nuisances at the model value");
      else 
         Info("StandardHypoTestInvDemo","Using LEP test statistic - an initial fit has been done and the TS will use the nuisances at the best fit value");
   }


   // build test statistics and hypotest calculators for running the inverter 
  
   SimpleLikelihoodRatioTestStat slrts(*sbModel->GetPdf(),*bModel->GetPdf());

   // null parameters must includes snapshot of poi plus the nuisance values 
   RooArgSet nullParams(*sbModel->GetSnapshot());
   if (sbModel->GetNuisanceParameters()) nullParams.add(*sbModel->GetNuisanceParameters());
   if (sbModel->GetSnapshot()) slrts.SetNullParameters(nullParams);
   RooArgSet altParams(*bModel->GetSnapshot());
   if (bModel->GetNuisanceParameters()) altParams.add(*bModel->GetNuisanceParameters());
   if (bModel->GetSnapshot()) slrts.SetAltParameters(altParams);
  
   // ratio of profile likelihood - need to pass snapshot for the alt
   RatioOfProfiledLikelihoodsTestStat 
      ropl(*sbModel->GetPdf(), *bModel->GetPdf(), bModel->GetSnapshot());
   ropl.SetSubtractMLE(false);
   if (testStatType == 11) ropl.SetSubtractMLE(true);
   ropl.SetPrintLevel(mPrintLevel);
   ropl.SetMinimizer(minimizerType.c_str());
  
   ProfileLikelihoodTestStat profll(*sbModel->GetPdf());
   if (testStatType == 3) profll.SetOneSided(true);
   if (testStatType == 4) profll.SetSigned(true);
   profll.SetMinimizer(minimizerType.c_str());
   profll.SetPrintLevel(mPrintLevel);

   profll.SetReuseNLL(mOptimize);
   slrts.SetReuseNLL(mOptimize);
   ropl.SetReuseNLL(mOptimize);

   if (mOptimize) { 
      profll.SetStrategy(0);
      ropl.SetStrategy(0);
      ROOT::Math::MinimizerOptions::SetDefaultStrategy(0);
   }
  
   if (mMaxPoi > 0) poi->setMax(mMaxPoi);  // increase limit
  
   MaxLikelihoodEstimateTestStat maxll(*sbModel->GetPdf(),*poi); 
   NumEventsTestStat nevtts;

   AsymptoticCalculator::SetPrintLevel(mPrintLevel);
  
   // create the HypoTest calculator class 
   HypoTestCalculatorGeneric *  hc = 0;
   if (type == 0) hc = new FrequentistCalculator(*data, *bModel, *sbModel);
   else if (type == 1) hc = new HybridCalculator(*data, *bModel, *sbModel);
   else if (type == 2 ) hc = new AsymptoticCalculator(*data, *bModel, *sbModel);
   else if (type == 3 ) hc = new AsymptoticCalculator(*data, *bModel, *sbModel, true);  // for using Asimov data generated with nominal values 
   else {
      Error("StandardHypoTestInvDemo","Invalid - calculator type = %d supported values are only :\n\t\t\t 0 (Frequentist) , 1 (Hybrid) , 2 (Asymptotic) ",type);
      return 0;
   }
  
   // set the test statistic 
   TestStatistic * testStat = 0;
   if (testStatType == 0) testStat = &slrts;
   if (testStatType == 1 || testStatType == 11) testStat = &ropl;
   if (testStatType == 2 || testStatType == 3 || testStatType == 4) testStat = &profll;
   if (testStatType == 5) testStat = &maxll;
   if (testStatType == 6) testStat = &nevtts;

   if (testStat == 0) { 
      Error("StandardHypoTestInvDemo","Invalid - test statistic type = %d supported values are only :\n\t\t\t 0 (SLR) , 1 (Tevatron) , 2 (PLR), 3 (PLR1), 4(MLE)",testStatType);
      return 0;
   }
  
  
   ToyMCSampler *toymcs = (ToyMCSampler*)hc->GetTestStatSampler();
   if (toymcs && (type == 0 || type == 1) ) { 
      // look if pdf is number counting or extended
      if (sbModel->GetPdf()->canBeExtended() ) { 
         if (useNumberCounting)   Warning("StandardHypoTestInvDemo","Pdf is extended: but number counting flag is set: ignore it ");
      }
      else { 
         // for not extended pdf
         if (!useNumberCounting  )  { 
            int nEvents = data->numEntries();
            Info("StandardHypoTestInvDemo","Pdf is not extended: number of events to generate taken  from observed data set is %d",nEvents);
            toymcs->SetNEventsPerToy(nEvents);
         }
         else {
            Info("StandardHypoTestInvDemo","using a number counting pdf");
            toymcs->SetNEventsPerToy(1);
         }
      }

      toymcs->SetTestStatistic(testStat);
    
      if (data->isWeighted() && !mGenerateBinned) { 
         Info("StandardHypoTestInvDemo","Data set is weighted, nentries = %d and sum of weights = %8.1f but toy generation is unbinned - it would be faster to set mGenerateBinned to true\n",data->numEntries(), data->sumEntries());
      }
      toymcs->SetGenerateBinned(mGenerateBinned);
  
      toymcs->SetUseMultiGen(mOptimize);
    
      if (mGenerateBinned &&  sbModel->GetObservables()->getSize() > 2) { 
         Warning("StandardHypoTestInvDemo","generate binned is activated but the number of ovservable is %d. Too much memory could be needed for allocating all the bins",sbModel->GetObservables()->getSize() );
      }

      // set the random seed if needed
      if (mRandomSeed >= 0) RooRandom::randomGenerator()->SetSeed(mRandomSeed); 
    
   }
  
  
   if (type == 1) { 
      HybridCalculator *hhc = dynamic_cast<HybridCalculator*> (hc);
      assert(hhc);
    
      hhc->SetToys(ntoys,ntoys/mNToysRatio); // can use less ntoys for b hypothesis 
    
      // remove global observables from ModelConfig (this is probably not needed anymore in 5.32)
      bModel->SetGlobalObservables(RooArgSet() );
      sbModel->SetGlobalObservables(RooArgSet() );
    
    
      // check for nuisance prior pdf in case of nuisance parameters 
      if (bModel->GetNuisanceParameters() || sbModel->GetNuisanceParameters() ) {

         // fix for using multigen (does not work in this case)
         toymcs->SetUseMultiGen(false);
         ToyMCSampler::SetAlwaysUseMultiGen(false);

         RooAbsPdf * nuisPdf = 0; 
         if (nuisPriorName) nuisPdf = w->pdf(nuisPriorName);
         // use prior defined first in bModel (then in SbModel)
         if (!nuisPdf)  { 
            Info("StandardHypoTestInvDemo","No nuisance pdf given for the HybridCalculator - try to deduce  pdf from the model");
            if (bModel->GetPdf() && bModel->GetObservables() ) 
               nuisPdf = RooStats::MakeNuisancePdf(*bModel,"nuisancePdf_bmodel");
            else 
               nuisPdf = RooStats::MakeNuisancePdf(*sbModel,"nuisancePdf_sbmodel");
         }   
         if (!nuisPdf ) {
            if (bModel->GetPriorPdf())  { 
               nuisPdf = bModel->GetPriorPdf();
               Info("StandardHypoTestInvDemo","No nuisance pdf given - try to use %s that is defined as a prior pdf in the B model",nuisPdf->GetName());            
            }
            else { 
               Error("StandardHypoTestInvDemo","Cannnot run Hybrid calculator because no prior on the nuisance parameter is specified or can be derived");
               return 0;
            }
         }
         assert(nuisPdf);
         Info("StandardHypoTestInvDemo","Using as nuisance Pdf ... " );
         nuisPdf->Print();
      
         const RooArgSet * nuisParams = (bModel->GetNuisanceParameters() ) ? bModel->GetNuisanceParameters() : sbModel->GetNuisanceParameters();
         RooArgSet * np = nuisPdf->getObservables(*nuisParams);
         if (np->getSize() == 0) { 
            Warning("StandardHypoTestInvDemo","Prior nuisance does not depend on nuisance parameters. They will be smeared in their full range");
         }
         delete np;
      
         hhc->ForcePriorNuisanceAlt(*nuisPdf);
         hhc->ForcePriorNuisanceNull(*nuisPdf);
      
      
      }
   } 
   else if (type == 2 || type == 3) { 
      if (testStatType == 3) ((AsymptoticCalculator*) hc)->SetOneSided(true);  
      if (testStatType != 2 && testStatType != 3)  
         Warning("StandardHypoTestInvDemo","Only the PL test statistic can be used with AsymptoticCalculator - use by default a two-sided PL");
   }
   else if (type == 0 || type == 1) 
      ((FrequentistCalculator*) hc)->SetToys(ntoys,ntoys/mNToysRatio); 

  
   // Get the result
   RooMsgService::instance().getStream(1).removeTopic(RooFit::NumIntegration);
  
  
  
   HypoTestInverter calc(*hc); // RunOnePoint ;; Test this son of a gun.  Try doing it at the same points that native calc is using;
   calc.SetConfidenceLevel(0.95);
  
  
   calc.UseCLs(useCLs);
   calc.SetVerbose(true);
  
   // can speed up using proof-lite
   if (mUseProof && mNWorkers > 1) { 
      ProofConfig pc(*w, mNWorkers, "", kFALSE);
      toymcs->SetProofConfig(&pc);    // enable proof
   }
  
  
   if (npoints > 0) {
      if (poimin > poimax) { 
         // if no min/max given scan between MLE and +4 sigma 
         poimin = int(poihat);
         poimax = int(poihat +  4 * poi->getError());
      }
      std::cout << "Doing a fixed scan  in interval : " << poimin << " , " << poimax << std::endl;
      calc.SetFixedScan(npoints,poimin,poimax);
   }
   else { 
      //poi->setMax(10*int( (poihat+ 10 *poi->getError() )/10 ) );
      std::cout << "Doing an  automatic scan  in interval : " << poi->getMin() << " , " << poi->getMax() << std::endl;
   }
  
   tw.Start();
   HypoTestInverterResult * r = calc.GetInterval();
   std::cout << "Time to perform limit scan \n";
   tw.Print();
  
   if (mRebuild) {
      calc.SetCloseProof(1);
      tw.Start();
      SamplingDistribution * limDist = calc.GetUpperLimitDistribution(true,mNToyToRebuild);
      std::cout << "Time to rebuild distributions " << std::endl;
      tw.Print();
    
      if (limDist) { 
         std::cout << "expected up limit " << limDist->InverseCDF(0.5) << " +/- " 
                   << limDist->InverseCDF(0.16) << "  " 
                   << limDist->InverseCDF(0.84) << "\n"; 
      
         //update r to a new updated result object containing the rebuilt expected p-values distributions
         // (it will not recompute the expected limit)
         if (r) delete r;  // need to delete previous object since GetInterval will return a cloned copy
         r = calc.GetInterval();
      
      }
      else 
         std::cout << "ERROR : failed to re-build distributions " << std::endl; 
   }
  
   return r;
}



void ReadResult(const char * fileName, const char * resultName="", bool useCLs=true) { 
   // read a previous stored result from a file given the result name

   StandardHypoTestInvDemo(fileName, resultName,"","","",0,0,useCLs);
}


#ifdef USE_AS_MAIN
int main() {
    StandardHypoTestInvDemo();
}
#endif