Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

Sign up for GitHub

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Jump to bottom

scDRS breaks if using all scRNA-seq genes as disease genes #23

Open
martinjzhang opened this issue Jul 24, 2022 · 0 comments
Open

scDRS breaks if using all scRNA-seq genes as disease genes #23

martinjzhang opened this issue Jul 24, 2022 · 0 comments
Assignees
@martinjzhang
Labels
enhancement New feature or request

Comments

@martinjzhang
Copy link
Owner

Some users may use all scRNA-seq genes as the trait gene set as some sort of negative control. scDRS produced miscalibrated results in this case due to numerical issues.

  • Raw control scores were slightly but systematically smaller than the disease score (1e-17).
  • Small SD of raw control of a given cell across control gene sets (1e-18).
@martinjzhang martinjzhang added the enhancement New feature or request label Aug 3, 2022
@martinjzhang martinjzhang self-assigned this Sep 30, 2022
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Assignees

@martinjzhang martinjzhang

Labels
enhancement New feature or request
Projects
None yet
Milestone
No milestone
Development

No branches or pull requests
1 participant
@martinjzhang