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CNKI CHKD.js
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CNKI CHKD.js
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/*
***** BEGIN LICENSE BLOCK *****
Copyright © 2024 jiaojiaodubai<[email protected]>
This file is part of Zotero.
Zotero is free software: you can redistribute it and/or modify
it under the terms of the GNU Affero General Public License as published by
the Free Software Foundation, either version 3 of the License, or
(at your option) any later version.
Zotero is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU Affero General Public License for more details.
You should have received a copy of the GNU Affero General Public License
along with Zotero. If not, see <http://www.gnu.org/licenses/>.
***** END LICENSE BLOCK *****
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"type": "web",
"url": "https://kns.cnki.net/kcms2/article/abstract?v=uzDkwlsKYf_ybnqiBgEkJImD70qS6iOlUtE74DoOYdEx1Uc_0fsKAAdVAmvQ__PHOdhBTtnZbFlnvGH_m7f2mgo-KF_8EHt94IzsGWygUsL9NsdJHKZ6KQ==&uniplatform=CHKD",
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"abstractNote": "在微创手术机器人系统中，传统线驱动式手术器械的偏摆关节与夹持器的转动关节之间存在运动耦合，这会对手术器械的运动精度产生不良影响。为此，提出了一种新型的四自由度线驱动式手术器械，其偏摆关节采用行星齿轮式结构，以实现偏摆关节与夹持器之间的运动解耦。首先，对传统线驱动式手术器械的关节运动耦合问题进行了分析。然后，设计了行星齿轮式转动的偏摆关节，并通过几何理论分析证明了其具有极低的关节耦合性，且钢丝绳在运动过程中的受迫形变量极小；同时，通过标准D-H参数法建立了新型手术器械的正运动学模型，并利用解析法求得了其逆运动学的封闭解。最后，分别使用MATLAB软件的Robotics Toolbox和Simulink环境中搭建的仿真模型对手术器械的正、逆运动学模型的准确性进行了验证，并采用蒙特卡罗法分析了其工作空间。仿真结果表明，所提出的手术器械的结构设计可靠，关节之间的运动耦合性较低，其工作空间能够满足微创外科手术的要求。研究结果可为柔性线驱动式手术器械的结构设计与运动学分析提供参考。",
"extra": "foundation: 国家自然科学基金青年基金资助项目（52005316）； 江苏省重点研发计划项目（BE2020082-3,BE2020082-4）； 特殊环境机器人技术四川省重点实验室开放基金资助项目（22kftk04）；\nCLC: TH77;TP242\nCNKICite: 0",
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"title": "Role of PDGFRA<sup>+</sup> cells and a CD55<sup>+</sup> PDGFRA<sup>Lo</sup> fraction in the gastric mesenchymal niche.",
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"DOI": "10.1038/s41467-023-43619-y",
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"abstractNote": "Abstract\n \n PDGFRA-expressing mesenchyme supports intestinal stem cells. Stomach epithelia have related niche dependencies, but their enabling mesenchymal cell populations are unknown, in part because previous studies pooled the gastric antrum and corpus. Our high-resolution imaging, transcriptional profiling, and organoid assays identify regional subpopulations and supportive capacities of purified mouse corpus and antral PDGFRA\n +\n cells. Sub-epithelial PDGFRA\n Hi\n myofibroblasts are principal sources of BMP ligands and two molecularly distinct pools distribute asymmetrically along antral glands but together fail to support epithelial growth in vitro. In contrast, PDGFRA\n Lo\n CD55\n +\n cells strategically positioned beneath gastric glands promote epithelial expansion in the absence of other cells or factors. This population encompasses a small fraction expressing the BMP antagonist\n Grem1\n . Although\n Grem1\n \n +\n \n cell ablation in vivo impairs intestinal stem cells, gastric stem cells are spared, implying that CD55\n +\n cell activity in epithelial self-renewal derives from other subpopulations. Our findings shed light on spatial, molecular, and functional organization of gastric mesenchyme and the spectrum of signaling sources for epithelial support.",
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"items": [
{
"itemType": "thesis",
"title": "风湿免疫病患者潜伏结核感染的流行病学特征、危险因素和预防性治疗状况探究",
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"lastName": "马亚楠",
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"lastName": "刘晓清",
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"date": "2023",
"abstractNote": "目的:调查我国风湿免疫病患者中T-SPOT.TB检测的阳性率,并分析影响T-SPOT.TB结果的相关因素;同时调查风湿免疫病患者预防性抗结核治疗的状况,为进一步规范风湿免疫病患者潜伏结核感染的预防与管理提供依据。方法:第一部分:风湿免疫病患者潜伏结核感染率及相关因素的多中心横断面研究纳入自2014年9月至2016年3月我国东、中、西部13家三级甲等综合医院接诊的风湿免疫病患者,应用T-SPOT.TB筛查LTBI。收集研究对象的基本信息,包括性别、年龄、地区、BMI、病程、吸烟史、基础疾病、结核病暴露史、结核病既往史、糖皮质激素、免疫抑制剂及生物制剂的使用情况、实验室化验、风湿免疫病诊断。采用单因素及多因素Logistic回归分析对T-SPOT.TB结果的影响因素进行分析。第二部分:系统性红斑狼疮患者潜伏结核感染率及相关因素的多中心横断面研究纳入自2014年9月至2016年3月我国东、中、西部13家三级甲等综合医院接诊的系统性红斑狼疮患者,应用T-SPOT.TB筛查LTBI。收集研究对象的基本信息,包括性别、年龄、BMI、病程、结核病既往史、SLEDAI-2K评分、糖皮质激素及免疫抑制剂的使用情况,采用单因素及多因素Logistic回归分析对T-SPOT.TB结果的影响因素进行分析。第三部分:风湿免疫病患者预防性抗结核治疗情况分析纳入自2014年9月至2016年3月我国东、中、西部13家三级甲等综合医院就诊的接受预防性抗结核治疗的风湿免疫病患者,分析研究对象风湿免疫病的类型及系统受累情况、结核活动的危险因素、预防性抗结核治疗方案及活动性结核病的发生情况。结果:第一部分:风湿免疫病患者潜伏结核感染率及相关因素的多中心横断面研究13445例风湿免疫病患者中有3715例患者进行了 T-SPOT.TB检测,其中检测阳性的患者有672例,风湿免疫病患者总体阳性率为18.1%(95%CI 16.9-19.3)。各病种T-SPOT.TB阳性率从8.9%到44.4%不等,不同病种之间T-SPOT.TB阳性率存在显著差异。男性T-SPOT.TB的阳性率总体高于女性,随年龄增加呈增高趋势。多因素Logistic回归分析显示:年龄大于40岁(OR 1.86,95%CI 1.51-2.28),吸烟(OR 1.65,95%CI 1.14-2.40),有结核既往史(OR 3.87,95%CI 2.72-5.51),患有白塞综合征的患者(OR ...",
"extra": "DOI: 10.27648/d.cnki.gzxhu.2023.000403\nmajor: 内科学（传染病学）（专业学位）\nCLC: R255.93;R254.3;R181.2;R52;R181.13;\nCNKICite: 0",
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"thesisType": "博士学位论文",
"university": "北京协和医学院",
"url": "https://doi.org/10.27648/d.cnki.gzxhu.2023.000403",
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"tags": [
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"tag": "T-SPOT.TB"
},
{
"tag": "潜伏结核感染"
},
{
"tag": "预防性干预"
},
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"tag": "风湿免疫病"
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],
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/** END TEST CASES **/