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As of yet, the old .writeCandidateVCFs function (see in history) didn't work because it only takes VCF objects (which can be created from VRanges objects), but we work with a GRanges object from the VEP step on. Thus, we can't write a VCF output file using that function.
Two ideas to make output VCFs possible:
Parse row names from GRanges to get the ref column needed to convert GRanges to VRanges
Output a VCF object from ensemblVEP. This would require refactoring the functions that follow (filtering, scoring, and ranking) to work with a VCF object rather than GRanges.
The text was updated successfully, but these errors were encountered:
As of yet, the old
.writeCandidateVCFs
function (see in history) didn't work because it only takes VCF objects (which can be created from VRanges objects), but we work with a GRanges object from the VEP step on. Thus, we can't write a VCF output file using that function.Two ideas to make output VCFs possible:
ref
column needed to convert GRanges to VRangesensemblVEP
. This would require refactoring the functions that follow (filtering, scoring, and ranking) to work with a VCF object rather than GRanges.The text was updated successfully, but these errors were encountered: