You have a split pane open in your current window. Perhaps it is running a local server or has a connection to a database. The pane is taking up too much space in the current window, but it is important so you don't want to just kill it. If that is the case, break it out into a separate window.
With that pane in focus, enter into command mode (<prefix>:) and then issue
the break-pane command.
Alternatively, you can trigger this with a keybinding: <prefix>!.
See man tmux for more details.