There are a ton of tabs, drop downs, and nested menus in Chrome's devtools. If I know what I am looking for, that is great, I can navigate to it without much trouble. But for other features and commands, I'm stumped and can end up spending minutes looking around.
For example, where is the option to 'Disable JavaScript'?
I don't know. And I don't need to know.
Instead of searching around for it, I can pop open the devtools command
palette with cmd+shift+p. This is a modal menu that prompts me to search for
a command to run. I start typing disab and already Disable JavaScript
appears as one of the top options. I can select that option and JavaScript will
be disabled.
When I'm ready to turn it back on. I can hit cmd+shift+p again and search for
enab. The Enable JavaScript option appears and I can select it to turn it
back on.
Note: you'll need to have the devtools panel open and your focus will need to be on it for the keybinding to be picked up.