Reading up to date relevant literature

[hollygene]

• think about how to write intro
• take notes on interesting/relevant papers

[hollygene]

Durao et al 2018 Trends in Microbiology
Review

Summarizes:
evolutionary mechanisms that influence maintenance of resistance, specifically fitness cost, compensatory evolution, epistasis, and environmental effects

Main Findings:

• sublethal doses of antimicrobials can increase rate and frequency of HGT, recombination, and mutation
• AMR mutations can be beneficial in other circumstances (like virulence, other env factors that aren't antimicrobials)

Future Directions/Outstanding Questions:

• how much can experimental evolution tell us about how it works in a host? i.e. interspecies ecological interactions?

My questions:

• is not taking a full "round" of antibiotics equivalent to a "sublethal dose?"

Relevant References:

• Chemical decay of an antibiotic inverts selection for resistance
• Microbiological effects of sublethal levels of antibiotics
• Interaction networks, ecological stability, and collective antibiotic tolerance in polymicrobial infections
• Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against S. aureus
• compensatory evolution in rifampin-resistant E coli
• Multiple mechanisms to ameliorate fitness burden of mupirocin resistance in S. typhinurium