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identify thermodynamically infeasible loops caused by cofactor specificity #3

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hariszaf opened this issue Nov 26, 2024 · 0 comments
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enhancement New feature or request

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@hariszaf
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Come up with a function to identify cases where more than 1 reactions are doing the same thing using different co-factors. This is a typical case for loopy solutions:

Example:

DR1ORx: nad_c[c] + dr5p[c]  <=> h_c[c] + nadh_c[c] + ru5p-D_c[c]

and

DR1ORy: nadp_c[c] + dr5p[c]  <=> h_c[c] + nadph_c[c] + ru5p-D_c[c]

If the cofactor specificity information is available, the reaction with non-specific cofactor can be removed or turned off.

If not, then..?

@hariszaf hariszaf added the enhancement New feature or request label Nov 26, 2024
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