From 06b7d7e3b9ce7e41fe5fa2749c2fe84be757dbc9 Mon Sep 17 00:00:00 2001 From: Stephanie Hicks Date: Mon, 12 Nov 2018 20:47:25 -0500 Subject: [PATCH] edits to Aim 2 and 3 --> tada --- content/04.body.md | 15 ++++++++------- 1 file changed, 8 insertions(+), 7 deletions(-) diff --git a/content/04.body.md b/content/04.body.md index bcdbf28..b404868 100644 --- a/content/04.body.md +++ b/content/04.body.md @@ -150,7 +150,7 @@ set of training data are represented in another [@doi:10.1101/395004,@doi:10.110 These provide a strong foundation to compare different low-dimensional representations through cross-validation techniques based upon learning representations in once source dataset and testing their ability to transfer in another target dataset. [**<-- didn't understand what was here before too well, please make sure I didn't muck with the meaning too much.**] [** Is this clearer? - EJF**] -Generalizable representations should also be robust in cross-study validation, transfering across datasets of related biological +Generalizable representations should also be robust in cross-study validation, transferring across datasets of related biological contexts, while representations of noise will not. In addition, we have found that combining multiple representations can better capture biological processes across scales [@doi:10.1016/j.cels.2017.06.003], and that representations across scales capture distinct, @@ -192,7 +192,7 @@ being developed work. Furthermore, researchers will need exposure to the concept low-dimensional interpretations of biological systems. This aim addresses these needs in three ways. -First, we will develop a bioinformatic training program for biologists at all levels, +First, we will develop a bioinformatic training program for biologists at all levels, including those with no experience in bioinformatics. Lecture materials will be extended from existing materials from previous bioinformatic courses we (PI Hampton) have run at Mount Desert Island Biological Laboratory, the University of Birmingham, UK, and Geisel @@ -201,9 +201,9 @@ in basic bioinformatics and always achieve approval ratings of over 90%. We bel the success of these learning experiences has to do with our instructional paradigm, which includes a very challenging course project coupled with one-on-one support from instructors. We will develop a new curriculum specifically tailored to HCA that incorporates: 1) didactic -course material on single cell gene expression profiling (PI Goff), 2) -machine learning methods (PI Greene), 4) statistics for genomics (PIs Fertig and Hicks), 4) search and analysis in low-dimensional -representations, and 5) tools developed by our group in response to this RFA. +course material on single cell gene expression profiling (PI Goff), 2) machine learning +methods (PI Greene), 4) statistics for genomics (PIs Fertig and Hicks), 4) search and analysis +in low-dimensional representations, and 5) tools developed by our group in response to this RFA. Second, the short course will train not only students, but also instructors. Our one-on-one approach to course projects will require a high instructor-to-student ratio. We will @@ -216,7 +216,8 @@ people who will drive the next wave of innovation. All of our course materials w freely available, enabling course participants to bring what they learned home with them. A capstone session will be included in which we will provide suggestions about how the materials presented in the course can be incorporated into existing course curricula. Course -faculty will be available to assist with integration effort after the course. Finally, the short course will facilitate scientific collaborations -by engaging participants in utilizing these tools for collaborative research efforts. +faculty will be available to assist with integration effort after the course. Finally, the short course +will facilitate scientific collaborations by engaging participants in utilizing these tools for +collaborative research efforts. **[I feel like we are missing a concluding summary of broader impacts to pull this together - could be a brief bulleted summary of tools required by app as Andrew suggested - EJF]**